ID   AAD10_YEAST             Reviewed;         288 AA.
AC   P47182; D6VWX4;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   10-JUN-2026, entry version 161.
DE   RecName: Full=Putative aryl-alcohol dehydrogenase AAD10;
DE            EC=1.1.1.-;
GN   Name=AAD10; OrderedLocusNames=YJR155W; ORFNames=J2245;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000305}.
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DR   EMBL; Z49655; CAA89688.1; -; Genomic_DNA.
DR   EMBL; AY557908; AAS56234.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08940.1; -; Genomic_DNA.
DR   PIR; S57184; S57184.
DR   RefSeq; NP_012689.1; NM_001181813.1.
DR   AlphaFoldDB; P47182; -.
DR   SMR; P47182; -.
DR   BioGRID; 33910; 47.
DR   FunCoup; P47182; 79.
DR   STRING; 4932.YJR155W; -.
DR   PaxDb; 4932-YJR155W; -.
DR   PeptideAtlas; P47182; -.
DR   EnsemblFungi; YJR155W_mRNA; YJR155W; YJR155W.
DR   GeneID; 853620; -.
DR   KEGG; sce:YJR155W; -.
DR   AGR; SGD:S000003916; -.
DR   SGD; S000003916; AAD10.
DR   VEuPathDB; FungiDB:YJR155W; -.
DR   eggNOG; KOG1575; Eukaryota.
DR   HOGENOM; CLU_023205_2_2_1; -.
DR   InParanoid; P47182; -.
DR   OMA; IALQPHY; -.
DR   OrthoDB; 48988at2759; -.
DR   BioCyc; YEAST:YJR155W-MONOMER; -.
DR   BioGRID-ORCS; 853620; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P47182; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; P47182; protein.
DR   GO; GO:0047681; F:aryl-alcohol dehydrogenase (NADP+) activity; ISS:SGD.
DR   GO; GO:0006081; P:aldehyde metabolic process; ISS:SGD.
DR   FunFam; 3.20.20.100:FF:000024; Aryl-alcohol dehydrogenase; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR050523; AKR_Detox_Biosynth.
DR   InterPro; IPR036812; NAD(P)_OxRdtase_dom_sf.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   PANTHER; PTHR43364:SF2; ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED; 1.
DR   PANTHER; PTHR43364; NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..288
FT                   /note="Putative aryl-alcohol dehydrogenase AAD10"
FT                   /id="PRO_0000070368"
SQ   SEQUENCE   288 AA;  32570 MW;  4E963216BE0600E2 CRC64;
     MASRKLRDQI VIATKFTTDY KGYDVGKGKS ANFCGNHKRS LHVSVRDSLR KLQTDWIDIL
     YVHWWDYMSS IEEVMDSLHI LVQQGKVLYL GVSDTPAWVV SAANYYATSH GKTPFSIYQG
     KWNVLNRDFE RDIIPMARHF GMALAPWDVM GGGRFQSKKA VEERKKKGEG LRTFFGTSEQ
     TDMEVKISEA LLKVAEEHGT ESVTAIAIAY VRSKAKHVFP LVGGRKIEHL KQNIEALSIK
     LTPEQIKYLE SIVPFDVGFP TNFIGDDPAV TKKPSFLTEM SAKISFED
//