ID   CKB1_CAEEL              Reviewed;         371 AA.
AC   P46558; Q8IS24;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2004, sequence version 2.
DT   02-SEP-2026, entry version 143.
DE   RecName: Full=Choline kinase B1;
DE            EC=2.7.1.32;
GN   Name=ckb-1; ORFNames=B0285.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12758145; DOI=10.1016/s1570-9639(03)00106-7;
RA   Gee P., Kent C.;
RT   "Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning,
RT   expression, purification, and characterization.";
RL   Biochim. Biophys. Acta 1648:33-42(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=choline + ATP = phosphocholine + ADP + H(+);
CC         Xref=Rhea:RHEA:12837, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:295975, ChEBI:CHEBI:456216;
CC         EC=2.7.1.32;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC       {ECO:0000305}.
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DR   EMBL; AY158690; AAN41642.1; -; mRNA.
DR   EMBL; Z34533; CAA84300.2; -; Genomic_DNA.
DR   PIR; T18695; T18695.
DR   RefSeq; NP_497879.2; NM_065478.4.
DR   AlphaFoldDB; P46558; -.
DR   SMR; P46558; -.
DR   BioGRID; 46770; 1.
DR   FunCoup; P46558; 107.
DR   STRING; 6239.B0285.8.1; -.
DR   PaxDb; 6239-B0285.8.1; -.
DR   PeptideAtlas; P46558; -.
DR   EnsemblMetazoa; B0285.8.1; B0285.8.1; WBGene00000511.
DR   GeneID; 181904; -.
DR   KEGG; cel:CELE_B0285.8; -.
DR   UCSC; B0285.8; c. elegans.
DR   AGR; WB:WBGene00000511; -.
DR   CTD; 181904; -.
DR   WormBase; B0285.8; CE33590; WBGene00000511; ckb-1.
DR   eggNOG; KOG2686; Eukaryota.
DR   HOGENOM; CLU_012712_2_0_1; -.
DR   InParanoid; P46558; -.
DR   OMA; NIMETYI; -.
DR   OrthoDB; 10267235at2759; -.
DR   PhylomeDB; P46558; -.
DR   Reactome; R-CEL-1483191; Synthesis of PC.
DR   Reactome; R-CEL-1483213; Synthesis of PE.
DR   PRO; PR:P46558; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000511; Expressed in material anatomical entity and 4 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004103; F:choline kinase activity; IBA:GO_Central.
DR   GO; GO:0004305; F:ethanolamine kinase activity; IBA:GO_Central.
DR   GO; GO:0006657; P:CDP-choline pathway; IBA:GO_Central.
DR   GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR22603:SF25; CHOLINE KINASE B1-RELATED; 1.
DR   PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR   Pfam; PF01633; Choline_kinase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Lipid biosynthesis; Lipid metabolism; Magnesium;
KW   Nucleotide-binding; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..371
FT                   /note="Choline kinase B1"
FT                   /id="PRO_0000206232"
SQ   SEQUENCE   371 AA;  42786 MW;  035F6EE53F026709 CRC64;
     MRPIEKFFTE NAPDSDLVIE KVIEFGIDFL GGEWKNVKKN EVKVTTILGG QSNHMFHVTS
     STSATPYLLR IHRQGPSHVF MDTVNFAIFS ERGLGPKLYG FFDGGRMEEF LPSRTLDSDC
     ILDPEISRRV GAVYPKYHAI DVPVSKKRRC FQVMRESLKE YQDLGGGDYE IKPTTVTYSE
     HPKKISMDDL YKEIDFMEKW TNELFEDTVV FCHNDLASSN ILELNSTKEL VLIDWEFGSY
     NCRGFDLAMH LAETAADFRD STPPGIRISE ELTDNPPNLQ GFCEAYVDAD NKLKNRVPSN
     RDLEVSNLIC ECQFFWPITQ LFWACFVMKL ALLKYNCGVD MDVQAQDRFA VYWHLKERTR
     KIYEDLKKGT C
//