ID   ARP6_DROME              Reviewed;         398 AA.
AC   P45890; Q9VXQ9;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   04-NOV-2026, entry version 169.
DE   RecName: Full=Actin-related protein 6;
DE            Short=dArp6;
DE   AltName: Full=Actin-like protein 13E;
GN   Name=Arp6; Synonyms=Acrp, Actr13E, Arp4; ORFNames=CG11678;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   STRAIN=Canton-S;
RX   PubMed=8308899; DOI=10.1006/jmbi.1994.1090;
RA   Frankel S., Heintzelman M.B., Artavanis-Tsakonas S., Mooseker M.S.;
RT   "Identification of a divergent actin-related protein in Drosophila.";
RL   J. Mol. Biol. 235:1351-1356(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5]
RP   SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX   PubMed=9378752; DOI=10.1242/jcs.110.17.1999;
RA   Frankel S., Sigel E.A., Craig C., Elgin S.C., Mooseker M.S.,
RA   Artavanis-Tsakonas S.;
RT   "An actin-related protein in Drosophila colocalizes with heterochromatin
RT   protein 1 in pericentric heterochromatin.";
RL   J. Cell Sci. 110:1999-2012(1997).
RN   [6]
RP   FUNCTION, IDENTIFICATION IN A SWR1-LIKE COMPLEX, AND SUBCELLULAR LOCATION.
RX   PubMed=32432549; DOI=10.7554/elife.56325;
RA   Scacchetti A., Schauer T., Reim A., Apostolou Z., Campos Sparr A.,
RA   Krause S., Heun P., Wierer M., Becker P.B.;
RT   "Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms.";
RL   Elife 9:e56325-e56325(2020).
CC   -!- FUNCTION: Component of a SWR1-like complex that incorporates H2A.V
CC       genome-wide and specifically at active promoters, in an ATP-dependent
CC       manner. {ECO:0000269|PubMed:32432549}.
CC   -!- SUBUNIT: Component of a SWR1-like complex at least composed of
CC       dom/Domino, Brd8, MrgBP, YL-1, Gas41, Bap55, Arp6, DMAP1, MRG15,
CC       pont/Pontin, rept/Reptin and Hcf. {ECO:0000269|PubMed:32432549}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000269|PubMed:32432549, ECO:0000269|PubMed:9378752}. Cytoplasm,
CC       cytoskeleton {ECO:0000269|PubMed:9378752}. Chromosome
CC       {ECO:0000305|PubMed:32432549}. Note=Colocalizes with Su(var)205/HP1 on
CC       centric heterochromatin.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       Expressed throughout development, with highest expression observed in
CC       embryos (at protein level). {ECO:0000269|PubMed:8308899,
CC       ECO:0000269|PubMed:9378752}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP6 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L25314; AAA17685.1; -; mRNA.
DR   EMBL; AE014298; AAF48499.1; -; Genomic_DNA.
DR   EMBL; AY058726; AAL13955.1; -; mRNA.
DR   PIR; S44028; S44028.
DR   RefSeq; NP_511165.1; NM_078610.3.
DR   AlphaFoldDB; P45890; -.
DR   SMR; P45890; -.
DR   BioGRID; 58864; 23.
DR   ComplexPortal; CPX-2423; SWR1 chromatin remodelling complex.
DR   DIP; DIP-17460N; -.
DR   FunCoup; P45890; 591.
DR   IntAct; P45890; 4.
DR   STRING; 7227.FBpp0073983; -.
DR   PaxDb; 7227-FBpp0073983; -.
DR   PeptideAtlas; P45890; -.
DR   DNASU; 32514; -.
DR   EnsemblMetazoa; FBtr0074203; FBpp0073983; FBgn0011741.
DR   GeneID; 32514; -.
DR   KEGG; dme:Dmel_CG11678; -.
DR   AGR; FB:FBgn0011741; -.
DR   CTD; 32514; -.
DR   FlyBase; FBgn0011741; Arp6.
DR   VEuPathDB; VectorBase:FBgn0011741; -.
DR   eggNOG; KOG0680; Eukaryota.
DR   HOGENOM; CLU_027965_1_1_1; -.
DR   InParanoid; P45890; -.
DR   OMA; AACYVTD; -.
DR   OrthoDB; 6220758at2759; -.
DR   PhylomeDB; P45890; -.
DR   SignaLink; P45890; -.
DR   BioGRID-ORCS; 32514; 1 hit in 1 CRISPR screen.
DR   GenomeRNAi; 32514; -.
DR   PRO; PR:P45890; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0011741; Expressed in eye disc (Drosophila) and 96 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; IDA:FlyBase.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0000812; C:Swr1 complex; IPI:ComplexPortal.
DR   GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0007000; P:nucleolus organization; IBA:GO_Central.
DR   GO; GO:0045815; P:transcription initiation-coupled chromatin remodeling; IMP:FlyBase.
DR   CDD; cd10210; ASKHA_NBD_Arp6; 1.
DR   FunFam; 2.30.36.70:FF:000003; Actin-related protein 6; 1.
DR   FunFam; 3.90.640.10:FF:000014; Putative actin-related protein 6; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   Gene3D; 2.30.36.70; Actin, Chain A, domain 2; 1.
DR   Gene3D; 3.90.640.10; Actin, Chain A, domain 4; 1.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; ACTIN; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   1: Evidence at protein level;
KW   Chromosome; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT   CHAIN           1..398
FT                   /note="Actin-related protein 6"
FT                   /id="PRO_0000089108"
SQ   SEQUENCE   398 AA;  45415 MW;  71905627B3F0FC05 CRC64;
     MANAVVVLDN GAHTAKVGLA NQDEPHVVPN CIMKAKSERR RAFVGNQIDE CRDTSALYYI
     LAFQRGYLLN WHTQKTVWDY IFSKDGIGCS LENRNIVITE PQMNFQSIQE ATLEILFEEY
     KVDGVYKTTA ADLAAFNYVA DSEERTTMES LNCIIIDVGY SFTHVVPFVL GRRVLQGIRR
     IDMGGKALTN QLKELISYRH LNVMDESHVV NQIKEDVCFV AEDFKQAMQV HYSEEKRREV
     TVDYVLPDFT TVKRGYVRVP GKPREDEEQQ QMVSLCNERF TVPELLFNPS DIGVQQVGIP
     EAVADCLKAC PWEAHRELLL NILIVGGSAQ FPGFLPRLKR DLRALVPDDL EVSLICPEDP
     VRYAWYGGKE VATSPNFEEF VYTQDDYEEY GFQGINQR
//