ID   CCMF_RHIME              Reviewed;         676 AA.
AC   P45404;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   02-SEP-2026, entry version 123.
DE   RecName: Full=Cytochrome c-type biogenesis protein CycK;
GN   Name=cycK; OrderedLocusNames=R01019; ORFNames=SMc02363;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC   Hyphomicrobiales; Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AK631;
RX   PubMed=7715602; DOI=10.1007/bf00425819;
RA   Kereszt A., Slaska-Kiss K., Putnoky P., Banfalvi Z., Kondorosi A.;
RT   "The cycHJKL genes of Rhizobium meliloti involved in cytochrome c
RT   biogenesis are required for 'respiratory' nitrate reduction ex planta and
RT   for nitrogen fixation during symbiosis.";
RL   Mol. Gen. Genet. 247:39-47(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- FUNCTION: Required for the biogenesis of c-type cytochromes. Possible
CC       subunit of a heme lyase.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CC       {ECO:0000305}.
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DR   EMBL; X82560; CAA57906.1; -; Genomic_DNA.
DR   EMBL; AL591688; CAC45591.1; -; Genomic_DNA.
DR   PIR; S54750; S54750.
DR   RefSeq; WP_010968989.1; NC_003047.1.
DR   AlphaFoldDB; P45404; -.
DR   SMR; P45404; -.
DR   EnsemblBacteria; CAC45591; CAC45591; SMc02363.
DR   KEGG; sme:SMc02363; -.
DR   PATRIC; fig|266834.11.peg.2423; -.
DR   eggNOG; COG1138; Bacteria.
DR   HOGENOM; CLU_015041_3_0_5; -.
DR   OrthoDB; 9761451at2; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:InterPro.
DR   InterPro; IPR032523; CcmF_C.
DR   InterPro; IPR002541; Cyt_c_assembly.
DR   InterPro; IPR003567; Cyt_c_biogenesis.
DR   InterPro; IPR003568; Cyt_c_biogenesis_CcmF.
DR   NCBIfam; TIGR00353; nrfE; 1.
DR   NCBIfam; NF007691; PRK10369.1; 1.
DR   PANTHER; PTHR43653; CYTOCHROME C ASSEMBLY PROTEIN-RELATED; 1.
DR   PANTHER; PTHR43653:SF1; CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMF; 1.
DR   Pfam; PF16327; CcmF_C; 1.
DR   Pfam; PF01578; Cytochrom_C_asm; 1.
DR   PRINTS; PR01410; CCBIOGENESIS.
DR   PRINTS; PR01411; CCMFBIOGNSIS.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cytochrome c-type biogenesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..676
FT                   /note="Cytochrome c-type biogenesis protein CycK"
FT                   /id="PRO_0000201587"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        445..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        493..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        617..637
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        319
FT                   /note="V -> I (in Ref. 1; CAA57906)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        658
FT                   /note="H -> R (in Ref. 1; CAA57906)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   676 AA;  72611 MW;  A2DD652280895E0D CRC64;
     MIIELGHYAL VLALATAIIQ GVLPVLGVRR GDPSLMGLAA NAALVCFLLV AFSFAVLTFA
     YVTSDFSVKN VWENSHSLKP LIYKITGVWG NHEGSMLLWL LILVFFSAMV ALFGRNLPET
     LKANVLAVQA WIATAFAFFV LLTSNPFARL VPAPGEGRDL NPVLQDIGLA IHPPLLYLGY
     VGFSVCFSFA VAALIEGRID AAWARWVRPW TLAAWTFLTA GIAMGSYWAY YELGWGGWWF
     WDPVENASFM PWLAGTALLH SALVMEKREA LKIWTVLLAI MTFSLSLLGT FLVRSGVLTS
     VHAFATDPTR GVFILAILVV FIGGAFSLFA FRASHLKAGG IFAPVSREGA LVVNNLILTT
     ATATVLTGTL YPLVLEALTG DKISVGAPFF NMTFGLLMLP LIAVVPFGPL LAWKRGDLAG
     AAQRLFAAAA LGLLAAAICY YAVNGGPVLA PFGLGLGVYL ILGALTDLVL RSGLGKVAAG
     VAWRRLSGLP RSAFGTALAH IGLGITLIGI VTVTAFETET VVEMKPGAVV DVGRYSLRFD
     GMREGRGPNY TEDAGHFTVS RGGVEVTEIW SSKRLYSARR MPTTEAGIRT FGLSQLYVSL
     GDDMADGGIV VRIWWKPLIL CIWGGALVMM AGGVVSLSDR RLRVGAPARA RKALALDHDD
     FRSDRPKIIN VIDSKG
//