ID   CDSA_HAEIN              Reviewed;         288 AA.
AC   P44937; O32623; O32627;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   02-SEP-2026, entry version 130.
DE   RecName: Full=Phosphatidate cytidylyltransferase;
DE            EC=2.7.7.41 {ECO:0000250|UniProtKB:P0ABG1};
DE   AltName: Full=CDP-diacylglycerol synthase;
DE            Short=CDP-DAG synthase;
DE            Short=CDP-DG synthase;
DE            Short=CDS;
DE   AltName: Full=CDP-diglyceride pyrophosphorylase;
DE   AltName: Full=CDP-diglyceride synthase;
DE   AltName: Full=CTP:phosphatidate cytidylyltransferase;
GN   Name=cdsA; Synonyms=cds; OrderedLocusNames=HI_0919;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Pasteurellales; Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=33, and Eagan / Serotype B;
RA   Loosmore S.M., Yang Y., Coleman D.C., Shortreed J.M., England D.M.,
RA   Klein M.H.;
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transferase that catalyzes the synthesis of a CDP-
CC       diacylglycerol (CDP-DAG), the activated form of a phosphatidate.
CC       {ECO:0000250|UniProtKB:P0ABG1}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-
CC         diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC         ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41;
CC         Evidence={ECO:0000250|UniProtKB:P0ABG1};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16230;
CC         Evidence={ECO:0000250|UniProtKB:P0ABG1};
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-
CC       diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC       {ECO:0000250|UniProtKB:P0ABG1}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0ABG1}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the CDS family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC22577.1; -; Genomic_DNA.
DR   EMBL; U60831; AAB61967.1; -; Genomic_DNA.
DR   EMBL; U60832; AAB61972.1; -; Genomic_DNA.
DR   PIR; G64102; G64102.
DR   AlphaFoldDB; P44937; -.
DR   SMR; P44937; -.
DR   STRING; 71421.HI_0919; -.
DR   EnsemblBacteria; AAC22577; AAC22577; HI_0919.
DR   KEGG; hin:HI_0919; -.
DR   PATRIC; fig|71421.8.peg.960; -.
DR   eggNOG; COG0575; Bacteria.
DR   HOGENOM; CLU_037294_1_2_6; -.
DR   OrthoDB; 9799199at2; -.
DR   PhylomeDB; P44937; -.
DR   BioCyc; HINF71421:G1GJ1-958-MONOMER; -.
DR   UniPathway; UPA00557; UER00614.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR000374; PC_trans.
DR   PANTHER; PTHR46382; PHOSPHATIDATE CYTIDYLYLTRANSFERASE; 1.
DR   PANTHER; PTHR46382:SF1; PHOSPHATIDATE CYTIDYLYLTRANSFERASE; 1.
DR   Pfam; PF01148; CTP_transf_1; 1.
DR   PROSITE; PS01315; CDS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Lipid biosynthesis; Lipid metabolism;
KW   Membrane; Nucleotidyltransferase; Phospholipid biosynthesis;
KW   Phospholipid metabolism; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..288
FT                   /note="Phosphatidate cytidylyltransferase"
FT                   /id="PRO_0000090736"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         16
FT                   /note="V -> F (in strain: Eagan)"
FT   VARIANT         59
FT                   /note="T -> A (in strain: 33)"
FT   VARIANT         81
FT                   /note="R -> H (in strain: Eagan)"
SQ   SEQUENCE   288 AA;  32247 MW;  67FFBF29997FAFA5 CRC64;
     MLKQRVLSAI VLIAAVLCAL FLFTPFYFAL ALGAVAILGI WEWTQFARLK QPLIRFFVTT
     FLGVFIFLWL YTEGNYLDAG RVFEQHLQLL LINAVSWWGL ALLLVISYPK SAKFWSKNPL
     LQLLFAFSTL IPFVAGVLRL RLEHYTHDPY HGLFLLLYVF ILVWAADSGA YFSGRAFGKR
     KLAPKVSPGK SWEGVIGGLI TALVLAFIFI HFSNNTLVGD RNITGFIILS VATVAISVLG
     DLTESMFKRE SGVKDSSQLI PGHGGVLDRI DSLTAAVPFF SYFYFFVL
//