ID   Y042_HAEIN              Reviewed;         224 AA.
AC   P43930;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   04-NOV-2026, entry version 126.
DE   RecName: Full=Uncharacterized RNA pseudouridine synthase HI_0042;
DE            EC=5.4.99.-;
DE   AltName: Full=RNA pseudouridylate synthase;
DE   AltName: Full=RNA-uridine isomerase;
GN   OrderedLocusNames=HI_0042;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Pasteurellales; Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC21720.1; -; Genomic_DNA.
DR   PIR; B64000; B64000.
DR   AlphaFoldDB; P43930; -.
DR   SMR; P43930; -.
DR   STRING; 71421.HI_0042; -.
DR   EnsemblBacteria; AAC21720; AAC21720; HI_0042.
DR   KEGG; hin:HI_0042; -.
DR   PATRIC; fig|71421.8.peg.42; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_6_0_6; -.
DR   OMA; ADVQTWY; -.
DR   OrthoDB; 9807829at2; -.
DR   PhylomeDB; P43930; -.
DR   BioCyc; HINF71421:G1GJ1-42-MONOMER; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProtKB-ARBA.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IBA:GO_Central.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006508; PsdUridine_synth_RluA-like.
DR   InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR050188; RluA_PseudoU_synthase.
DR   NCBIfam; TIGR01621; RluA-like; 1.
DR   PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR   PANTHER; PTHR21600:SF87; RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..224
FT                   /note="Uncharacterized RNA pseudouridine synthase HI_0042"
FT                   /id="PRO_0000162726"
FT   ACT_SITE        52
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   224 AA;  25526 MW;  1EE581956D0E41BD CRC64;
     MEIEVVYQHS DFIIINKSEG ISVHKDQEEQ GLTELVAKQL NVPKVWLVHR LDKVTSGLLI
     LALNAESAAE FSRLFSEHKI HKTYLALSNQ KPKKKQGLII GDMKKAREGA WKLCQTKDNP
     AITRFESVSC EPNLRLFILK PQTGKTHQLR VAMKSLGSPI LGDGLYGKNT EKIDRTYLHA
     TQLEFDYLNN FISVTCLPSQ GQFWIKPTVF EQIQVYLTKP FLSK
//