ID   QOR_PSEAE               Reviewed;         325 AA.
AC   P43903;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   08-DEC-2000, sequence version 2.
DT   04-NOV-2026, entry version 145.
DE   RecName: Full=Quinone oxidoreductase;
DE            EC=1.6.5.5;
DE   AltName: Full=NADPH:quinone reductase;
GN   Name=qor; OrderedLocusNames=PA0023;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Pseudomonadales; Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1;
RA   Hungerer C., Troup B., Jahn D.;
RT   "Cloning and regulation of the Pseudomonas aeruginosa hemF gene encoding
RT   oxygen-dependent coproporphyrinogen III oxidase.";
RL   Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 a quinone + NADPH + H(+) = 2 a 1,4-benzosemiquinone +
CC         NADP(+); Xref=Rhea:RHEA:14269, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:132124, ChEBI:CHEBI:134225;
CC         EC=1.6.5.5;
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily. {ECO:0000305}.
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DR   EMBL; X85015; CAA59375.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG03413.1; -; Genomic_DNA.
DR   PIR; D83644; D83644.
DR   PIR; S52923; S52923.
DR   RefSeq; NP_248713.1; NC_002516.2.
DR   RefSeq; WP_003111202.1; NC_002516.2.
DR   AlphaFoldDB; P43903; -.
DR   SMR; P43903; -.
DR   FunCoup; P43903; 646.
DR   STRING; 208964.PA0023; -.
DR   PaxDb; 208964-PA0023; -.
DR   GeneID; 880685; -.
DR   KEGG; pae:PA0023; -.
DR   PATRIC; fig|208964.12.peg.22; -.
DR   PseudoCAP; PA0023; -.
DR   HOGENOM; CLU_026673_3_1_6; -.
DR   InParanoid; P43903; -.
DR   OMA; AAGTPYM; -.
DR   OrthoDB; 9805883at2; -.
DR   PhylomeDB; P43903; -.
DR   BioCyc; PAER208964:G1FZ6-23-MONOMER; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IBA:GO_Central.
DR   GO; GO:0003960; F:quinone reductase (NADPH) activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd05286; QOR2; 1.
DR   FunFam; 3.40.50.720:FF:000053; Quinone oxidoreductase 1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR020843; ER.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR047618; QOR-like.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   NCBIfam; NF008024; PRK10754.1; 1.
DR   PANTHER; PTHR48106; QUINONE OXIDOREDUCTASE PIG3-RELATED; 1.
DR   PANTHER; PTHR48106:SF13; QUINONE OXIDOREDUCTASE-RELATED; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..325
FT                   /note="Quinone oxidoreductase"
FT                   /id="PRO_0000160903"
FT   CONFLICT        10
FT                   /note="Y -> C (in Ref. 1; CAA59375)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   325 AA;  35095 MW;  059A49962FA2CE2A CRC64;
     MAKRIQFAAY GGPEVLEYRD YQPAEPGPRE VRVRNRAIGL NFIDTYYRSG LYPAPGLPSG
     LGSEGAGEVE AVGSEVTRFK VGDRVAYATG PLGAYSELHV LAEEKLVHLP DGIDFEQAAA
     VMLKGLTTQY LLRQTYELRG GETILFHAAA GGVGLFACQW AKALGVQLIG TVSSPEKARL
     ARQHGAWETI DYSHENVARR VLELTDGKKC PVVYDSVGKD TWETSLDCVA PRGLLVSFGN
     ASGPVTGVNL GILSQKGSLY VTRPTLGSYA DTPEKLQAMA DELFGLIERG DIRIEINQRF
     ALAEAARAHT ELAARRTTGS TVLLP
//