ID   FAR7_YEAST              Reviewed;         221 AA.
AC   P43592; D6VTN8;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   02-SEP-2026, entry version 147.
DE   RecName: Full=Factor arrest protein 7;
GN   Name=FAR7; OrderedLocusNames=YFR008W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7670463; DOI=10.1038/ng0795-261;
RA   Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA   Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA   Eki T.;
RT   "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT   cerevisiae.";
RL   Nat. Genet. 10:261-268(1995).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH FAR3; FAR8; FAR10; FAR11 AND VPS64.
RX   PubMed=12588993; DOI=10.1128/mcb.23.5.1750-1763.2003;
RA   Kemp H.A., Sprague G.F. Jr.;
RT   "Far3 and five interacting proteins prevent premature recovery from
RT   pheromone arrest in the budding yeast Saccharomyces cerevisiae.";
RL   Mol. Cell. Biol. 23:1750-1763(2003).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Participates in the control of the reentry into the cell
CC       cycle following pheromone treatment. {ECO:0000269|PubMed:12588993}.
CC   -!- SUBUNIT: Component of a complex at least composed of FAR3, FAR7, FAR8,
CC       FAR10, FAR11 and VPS64.
CC   -!- INTERACTION:
CC       P43592; P46671: FAR3; NbExp=7; IntAct=EBI-22932, EBI-6789;
CC       P43592; Q05040: FAR8; NbExp=3; IntAct=EBI-22932, EBI-28053;
CC       P43592; Q03944: VPS64; NbExp=3; IntAct=EBI-22932, EBI-30418;
CC   -!- MISCELLANEOUS: Present with 1540 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; D50617; BAA09247.1; -; Genomic_DNA.
DR   EMBL; BK006940; DAA12448.1; -; Genomic_DNA.
DR   PIR; S56263; S56263.
DR   RefSeq; NP_116663.1; NM_001179973.1.
DR   AlphaFoldDB; P43592; -.
DR   SMR; P43592; -.
DR   BioGRID; 31157; 199.
DR   ComplexPortal; CPX-1197; PPG1-FAR complex.
DR   DIP; DIP-1315N; -.
DR   FunCoup; P43592; 88.
DR   IntAct; P43592; 12.
DR   MINT; P43592; -.
DR   STRING; 4932.YFR008W; -.
DR   iPTMnet; P43592; -.
DR   PaxDb; 4932-YFR008W; -.
DR   PeptideAtlas; P43592; -.
DR   EnsemblFungi; YFR008W_mRNA; YFR008W; YFR008W.
DR   GeneID; 850559; -.
DR   KEGG; sce:YFR008W; -.
DR   AGR; SGD:S000001904; -.
DR   SGD; S000001904; FAR7.
DR   VEuPathDB; FungiDB:YFR008W; -.
DR   eggNOG; ENOG502S5IA; Eukaryota.
DR   HOGENOM; CLU_103442_0_0_1; -.
DR   InParanoid; P43592; -.
DR   OMA; HMYLLVN; -.
DR   OrthoDB; 4067912at2759; -.
DR   BioCyc; YEAST:G3O-30461-MONOMER; -.
DR   BioGRID-ORCS; 850559; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P43592; -.
DR   Proteomes; UP000002311; Chromosome VI.
DR   RNAct; P43592; protein.
DR   GO; GO:0005829; C:cytosol; HDA:SGD.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:SGD.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; NAS:ComplexPortal.
DR   GO; GO:0090443; C:FAR/SIN/STRIPAK complex; NAS:ComplexPortal.
DR   GO; GO:0005739; C:mitochondrion; NAS:ComplexPortal.
DR   GO; GO:0071444; P:cellular response to pheromone; NAS:ComplexPortal.
DR   GO; GO:0000321; P:re-entry into mitotic cell cycle after pheromone arrest; IGI:SGD.
DR   GO; GO:0010506; P:regulation of autophagy; NAS:ComplexPortal.
DR   GO; GO:1903939; P:regulation of TORC2 signaling; NAS:ComplexPortal.
PE   1: Evidence at protein level;
KW   Cell cycle; Reference proteome.
FT   CHAIN           1..221
FT                   /note="Factor arrest protein 7"
FT                   /id="PRO_0000087192"
SQ   SEQUENCE   221 AA;  25915 MW;  81156978FF7AAD54 CRC64;
     MSDQINVLSM QQQQQQQQQQ QQVYMSPQAE NLNHMYLLVN KLVKQLRENQ AEKAKILRNI
     DILSGSLNKY ETSEEPHDTT ENIALFNRFL EQRGKAPITE KEQLSNNLDE NAKDDVMLGV
     LKRQNSMLRK SLQESKQVTL ESMDLLSYSE DSLNYIVAQL RGNILMHHKE TIKLIRQKFQ
     TETIPLEDEE FKMYLENVNG LQKLTDISHT YRLLLRLHAQ D
//