ID   YFL57_YEAST             Reviewed;         152 AA.
AC   P43546; D6VTH3;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   02-SEP-2026, entry version 151.
DE   RecName: Full=Putative aryl-alcohol dehydrogenase YFL057C {ECO:0000305};
DE            EC=1.1.1.-;
GN   OrderedLocusNames=YFL057C {ECO:0000312|SGD:S000001837};
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7670463; DOI=10.1038/ng0795-261;
RA   Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA   Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA   Eki T.;
RT   "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT   cerevisiae.";
RL   Nat. Genet. 10:261-268(1995).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   IDENTIFICATION OF FRAMESHIFT.
RX   PubMed=10581269; DOI=10.1093/genetics/153.4.1591;
RA   Delneri D., Gardner D.C.J., Oliver S.G.;
RT   "Analysis of the seven-member AAD gene set demonstrates that genetic
RT   redundancy in yeast may be more apparent than real.";
RL   Genetics 153:1591-1600(1999).
CC   -!- FUNCTION: Putative aryl-alcohol dehydrogenase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene unlikely to encode a
CC       functional protein. This is the C-terminal part of an aryl-alcohol
CC       dehydrogenase homolog of the AAD family. In strain S288c, a -1
CC       frameshift disrupts the gene coding for this protein and produces two
CC       ORFs YFL056C and YFL057C. Because of that it is not part of the
CC       S.cerevisiae S288c complete/reference proteome set.
CC       {ECO:0000305|PubMed:10581269, ECO:0000305|PubMed:24374639}.
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DR   EMBL; D50617; BAA09184.1; -; Genomic_DNA.
DR   EMBL; AY557801; AAS56127.1; -; Genomic_DNA.
DR   PIR; S56198; S56198.
DR   AlphaFoldDB; P43546; -.
DR   SMR; P43546; -.
DR   BioGRID; 31090; 20.
DR   SGD; S000001837; YFL057C.
DR   eggNOG; KOG1575; Eukaryota.
DR   HOGENOM; CLU_138066_1_0_1; -.
DR   FunFam; 3.20.20.100:FF:000065; Aryl-alcohol dehydrogenase; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR050523; AKR_Detox_Biosynth.
DR   InterPro; IPR036812; NAD(P)_OxRdtase_dom_sf.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   PANTHER; PTHR43364:SF2; ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED; 1.
DR   PANTHER; PTHR43364; NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE   5: Uncertain;
KW   Oxidoreductase.
FT   CHAIN           1..152
FT                   /note="Putative aryl-alcohol dehydrogenase YFL057C"
FT                   /id="PRO_0000070371"
SQ   SEQUENCE   152 AA;  16595 MW;  AFC4910A984D7434 CRC64;
     MARHFGMALA PWDVMGGGRF QSKKAMEERR KNGEGIRSFV GASEQTDAEI KISEALAKVA
     EEHGTESVTA IAIAYVRSKA KNVFPLVGGR KIEHLKQNIE ALSIKLTPEQ IKYLESIIPF
     DVGFPTNFIG DDPAVTKKAS LLTAMSAQIS FD
//