ID   YFG6_YEAST              Reviewed;         392 AA.
AC   P43538; D6VTG5;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   04-NOV-2026, entry version 174.
DE   RecName: Full=Y' element ATP-dependent helicase YFL066C;
DE            EC=5.6.2.- {ECO:0000305|PubMed:9837911};
GN   OrderedLocusNames=YFL066C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7670463; DOI=10.1038/ng0795-261;
RA   Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA   Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA   Eki T.;
RT   "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT   cerevisiae.";
RL   Nat. Genet. 10:261-268(1995).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=9837911; DOI=10.1074/jbc.273.50.33360;
RA   Yamada M., Hayatsu N., Matsuura A., Ishikawa F.;
RT   "Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is
RT   induced in survivors defective for telomerase.";
RL   J. Biol. Chem. 273:33360-33366(1998).
CC   -!- FUNCTION: Catalyzes DNA unwinding and is involved in telomerase-
CC       independent telomere maintenance. {ECO:0000305|PubMed:9837911}.
CC   -!- INDUCTION: Induced in absence of telomerase TLC1.
CC       {ECO:0000305|PubMed:9837911}.
CC   -!- SIMILARITY: Belongs to the helicase family. Yeast subtelomeric Y'
CC       repeat subfamily. {ECO:0000305}.
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DR   EMBL; D50617; BAA09175.1; -; Genomic_DNA.
DR   EMBL; BK006940; DAA12375.1; -; Genomic_DNA.
DR   PIR; S56189; S56189.
DR   RefSeq; NP_116589.1; NM_001179901.1.
DR   AlphaFoldDB; P43538; -.
DR   BioGRID; 31082; 4.
DR   DIP; DIP-2599N; -.
DR   FunCoup; P43538; 94.
DR   IntAct; P43538; 2.
DR   STRING; 4932.YFL066C; -.
DR   PaxDb; 4932-YFL066C; -.
DR   PeptideAtlas; P43538; -.
DR   TopDownProteomics; P43538; -.
DR   EnsemblFungi; YFL066C_mRNA; YFL066C; YFL066C.
DR   GeneID; 850478; -.
DR   KEGG; sce:YFL066C; -.
DR   AGR; SGD:S000001828; -.
DR   SGD; S000001828; YFL066C.
DR   VEuPathDB; FungiDB:YFL066C; -.
DR   HOGENOM; CLU_034495_0_0_1; -.
DR   InParanoid; P43538; -.
DR   OMA; QHVGCCV; -.
DR   OrthoDB; 4070089at2759; -.
DR   BioCyc; YEAST:G3O-30402-MONOMER; -.
DR   PRO; PR:P43538; -.
DR   Proteomes; UP000002311; Chromosome VI.
DR   RNAct; P43538; protein.
DR   GO; GO:0005634; C:nucleus; HDA:SGD.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   FunFam; 3.40.50.300:FF:001914; YML133C-like protein; 1.
DR   FunFam; 3.40.50.300:FF:002410; YML133C-like protein; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR001650; Helicase_C-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR051363; RLR_Helicase.
DR   PANTHER; PTHR14074:SF39; FANCONI ANEMIA GROUP M PROTEIN; 1.
DR   PANTHER; PTHR14074; HELICASE WITH DEATH DOMAIN-RELATED; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Helicase; Hydrolase; Isomerase; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..392
FT                   /note="Y' element ATP-dependent helicase YFL066C"
FT                   /id="PRO_0000102206"
FT   DOMAIN          1..175
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          232..381
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   BINDING         11..18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   392 AA;  43829 MW;  644E5C7FF9B12579 CRC64;
     MADTPSVAVQ APPGYGKTEL FHLPLIALAS KGDVKYVSFL FVPYTVLLAN CMIRLGRRGC
     LNVAPVRNFI EEGYDGVTDL YVGIYDDLAS TNFTDRIAAW ENIVECTFRT NNVKLGYLIV
     DEFHNFETEV YRQSQFGGIT NLDFDAFEKA IFLSGTAPEA VADAALQRIG LTGLAKKSMD
     INELKRSEDL SRGLSSYPTR MFNLIKEKSE VPLGHVHKIW KKVESQPEEA LKLLLALFEI
     EPESKAIVVA STTNEVEELA CSWRKYFRVV WIHGKLGAAE KVSRTKEFVT DGSMQVLIGT
     KLVTEGIDIK QLMMVIMLDN RLNIIELIQG VGRLRDGGLC YLLSRKNSWA ARNRKGELPP
     IKEGCITEQV REFYGLESKK GKKGQHVGCC VC
//