ID   ALL11_ARAHY             Reviewed;         614 AA.
AC   P43237;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   04-NOV-2026, entry version 99.
DE   RecName: Full=Allergen Ara h 1;
DE   AltName: Allergen=Ara h 1;
DE   Flags: Precursor;
OS   Arachis hypogaea (Peanut).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   dalbergioids sensu lato; Dalbergieae; Pterocarpus clade; Arachis.
OX   NCBI_TaxID=3818;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Florunner;
RX   PubMed=7560062; DOI=10.1172/jci118216;
RA   Burks A.W., Cockrell G., Stanley J.S., Helm R.M., Bannon G.A.;
RT   "Recombinant peanut allergen Ara h I expression and IgE binding in patients
RT   with peanut hypersensitivity.";
RL   J. Clin. Invest. 96:1715-1721(1995).
RN   [2]
RP   GLYCOSYLATION AT ASN-516.
RX   PubMed=10998264; DOI=10.1006/abio.2000.4737;
RA   Kolarich D., Altmann F.;
RT   "N-glycan analysis by matrix-assisted laser desorption/ionization mass
RT   spectrometry of electrophoretically separated nonmammalian proteins:
RT   application to peanut allergen Ara h 1 and olive pollen allergen Ole e 1.";
RL   Anal. Biochem. 285:64-75(2000).
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the 7S seed storage protein family.
CC       {ECO:0000305}.
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DR   EMBL; L38853; AAA60336.1; -; mRNA.
DR   RefSeq; NP_001363136.1; NM_001376207.1.
DR   AlphaFoldDB; P43237; -.
DR   SMR; P43237; -.
DR   IntAct; P43237; 5.
DR   Allergome; 50; Ara h 1.
DR   GlyConnect; P43237; 5 N-Linked glycans (1 site).
DR   GlyCosmos; P43237; 1 site, 8 glycans.
DR   EnsemblPlants; arahy.Tifrunner.gnm2.ann2.Ah09g360700.1; arahy.Tifrunner.gnm2.ann2.Ah09g360700.1-CDS; arahy.Tifrunner.gnm2.ann2.Ah09g360700.
DR   GeneID; 112711772; -.
DR   Gramene; arahy.Tifrunner.gnm2.ann2.Ah09g360700.1; arahy.Tifrunner.gnm2.ann2.Ah09g360700.1-CDS; arahy.Tifrunner.gnm2.ann2.Ah09g360700.
DR   KEGG; ahf:112711772; -.
DR   OrthoDB; 1425232at2759; -.
DR   CDD; cd02245; cupin_7S_vicilin-like_C; 1.
DR   CDD; cd02244; cupin_7S_vicilin-like_N; 1.
DR   FunFam; 2.60.120.10:FF:000162; Beta-conglycinin beta subunit 1; 1.
DR   FunFam; 2.60.120.10:FF:000181; Beta-conglycinin beta subunit 1; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR   InterPro; IPR006045; Cupin_1.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   InterPro; IPR050253; Seed_Storage-Functional.
DR   PANTHER; PTHR31189; OS03G0336100 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR31189:SF41; VICILIN C72; 1.
DR   Pfam; PF00190; Cupin_1; 2.
DR   SMART; SM00835; Cupin_1; 2.
DR   SUPFAM; SSF51182; RmlC-like cupins; 2.
PE   1: Evidence at protein level;
KW   Allergen; Glycoprotein; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..614
FT                   /note="Allergen Ara h 1"
FT                   /id="PRO_0000032196"
FT   DOMAIN          169..327
FT                   /note="Cupin type-1 1"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          390..566
FT                   /note="Cupin type-1 2"
FT                   /evidence="ECO:0000255"
FT   REGION          72..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          372..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          464..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          572..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..132
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..474
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..486
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        516
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:10998264"
FT                   /id="CAR_000218"
SQ   SEQUENCE   614 AA;  70283 MW;  1DDACF217EEC5F31 CRC64;
     MRGRVSPLML LLGILVLASV SATQAKSPYR KTENPCAQRC LQSCQQEPDD LKQKACESRC
     TKLEYDPRCV YDTGATNQRH PPGERTRGRQ PGDYDDDRRQ PRREEGGRWG PAEPRERERE
     EDWRQPREDW RRPSHQQPRK IRPEGREGEQ EWGTPGSEVR EETSRNNPFY FPSRRFSTRY
     GNQNGRIRVL QRFDQRSKQF QNLQNHRIVQ IEARPNTLVL PKHADADNIL VIQQGQATVT
     VANGNNRKSF NLDEGHALRI PSGFISYILN RHDNQNLRVA KISMPVNTPG QFEDFFPASS
     RDQSSYLQGF SRNTLEAAFN AEFNEIRRVL LEENAGGEQE ERGQRRRSTR SSDNEGVIVK
     VSKEHVQELT KHAKSVSKKG SEEEDITNPI NLRDGEPDLS NNFGRLFEVK PDKKNPQLQD
     LDMMLTCVEI KEGALMLPHF NSKAMVIVVV NKGTGNLELV AVRKEQQQRG RREQEWEEEE
     EDEEEEGSNR EVRRYTARLK EGDVFIMPAA HPVAINASSE LHLLGFGINA ENNHRIFLAG
     DKDNVIDQIE KQAKDLAFPG SGEQVEKLIK NQRESHFVSA RPQSQSPSSP EKEDQEEENQ
     GGKGPLLSIL KAFN
//