ID   GZF3_YEAST              Reviewed;         551 AA.
AC   P42944; D6VW74;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   02-SEP-2026, entry version 182.
DE   RecName: Full=Protein GZF3;
GN   Name=GZF3; OrderedLocusNames=YJL110C; ORFNames=J0806;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=7483851; DOI=10.1002/yea.320110909;
RA   Rasmussen S.W.;
RT   "A 37.5 kb region of yeast chromosome X includes the SME1, MEF2, GSH1 and
RT   CSD3 genes, a TCP-1-related gene, an open reading frame similar to the
RT   DAL80 gene, and a tRNA(Arg).";
RL   Yeast 11:873-883(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=8948101;
RX   DOI=10.1002/(sici)1097-0061(199611)12:14%3c1471::aid-yea30%3e3.0.co;2-4;
RA   Cziepluch C., Kordes E., Pujol A., Jauniaux J.-C.;
RT   "Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19
RT   open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14,
RT   RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta
RT   elements and a Ty4 transposon.";
RL   Yeast 12:1471-1474(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA   Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT   "A multidimensional chromatography technology for in-depth phosphoproteome
RT   analysis.";
RL   Mol. Cell. Proteomics 7:1389-1396(2008).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X85021; CAA59384.1; -; Genomic_DNA.
DR   EMBL; Z49385; CAA89405.1; -; Genomic_DNA.
DR   EMBL; X86353; CAA60126.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08690.1; -; Genomic_DNA.
DR   PIR; S53377; S53377.
DR   RefSeq; NP_012425.1; NM_001181543.1.
DR   AlphaFoldDB; P42944; -.
DR   SMR; P42944; -.
DR   BioGRID; 33646; 195.
DR   DIP; DIP-1359N; -.
DR   FunCoup; P42944; 801.
DR   IntAct; P42944; 13.
DR   MINT; P42944; -.
DR   STRING; 4932.YJL110C; -.
DR   GlyGen; P42944; 9 sites, 1 O-linked glycan (9 sites).
DR   iPTMnet; P42944; -.
DR   PaxDb; 4932-YJL110C; -.
DR   PeptideAtlas; P42944; -.
DR   EnsemblFungi; YJL110C_mRNA; YJL110C; YJL110C.
DR   GeneID; 853334; -.
DR   KEGG; sce:YJL110C; -.
DR   AGR; SGD:S000003646; -.
DR   SGD; S000003646; GZF3.
DR   VEuPathDB; FungiDB:YJL110C; -.
DR   eggNOG; KOG1601; Eukaryota.
DR   HOGENOM; CLU_594549_0_0_1; -.
DR   InParanoid; P42944; -.
DR   OMA; HINELDG; -.
DR   OrthoDB; 515401at2759; -.
DR   BioCyc; YEAST:G3O-31564-MONOMER; -.
DR   Reactome; R-SCE-9018519; Estrogen-dependent gene expression.
DR   BioGRID-ORCS; 853334; 0 hits in 13 CRISPR screens.
DR   PRO; PR:P42944; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; P42944; protein.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:SGD.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:SGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0051457; P:maintenance of protein location in nucleus; IPI:SGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:SGD.
DR   GO; GO:0090295; P:nitrogen catabolite repression of transcription; IMP:SGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00202; ZnF_GATA; 1.
DR   FunFam; 3.30.50.10:FF:000007; Nitrogen regulatory AreA, N-terminal; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071:SF281; BOX A-BINDING FACTOR-RELATED; 1.
DR   PANTHER; PTHR10071; TRANSCRIPTION FACTOR GATA FAMILY MEMBER; 1.
DR   Pfam; PF00320; GATA; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..551
FT                   /note="Protein GZF3"
FT                   /id="PRO_0000083488"
FT   ZN_FING         131..155
FT                   /note="GATA-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          17..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          467..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..239
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..254
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..400
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..477
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        478..490
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   551 AA;  60520 MW;  807243799BFAB704 CRC64;
     MASQATTLRG YNIRKRDNVF EPKSSENLNS LNQSEEEGHI GRWPPLGYEA VSAEQKSAVQ
     LRESQAGASI SNNMNFKAND KSFSTSTAGR MSPDTNSLHH ILPKNQVKNN GQTMDANCNN
     NVSNDANVPV CKNCLTSTTP LWRRDEHGAM LCNACGLFLK LHGKPRPISL KTDVIKSRNR
     KSNTNHAHNL DNFRNQTLIA ELKGDCNIES SGRKANRVTS EDKKKKSSQL LMGTSSTAKI
     SKKPKTESKE RSDSHLSATK LEVLMSGDCS RPNLKPKLPK QDTAIYQEKL LTFPSYTDVK
     EYSNSAHQSA FIKERSQFNA ASFPLNASHS VTSKTGADSP QLPHLSMLLG SLSSTSISNN
     GSEIVSNCNN GIASTAATLA PTSSRTTDSN PSEVPNQIRS TMSSPDIISA KRNDPAPLSF
     HMASINDMLE TRDRAISNVK TETTPPHFIP FLQSSKAPCI SKANSQSISN SVSSSDVSGR
     KFENHPAKDL GDQLSTKLHK EEEIIKLKTR INELELVTDL YRRHINELDG KCRALEERLQ
     RTVKQEGNKG G
//