ID   YG4I_YEAST              Reviewed;         411 AA.
AC   P42942; D6VUZ3;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   04-NOV-2026, entry version 175.
DE   RecName: Full=Uncharacterized GTP-binding protein YGR210C;
GN   OrderedLocusNames=YGR210C; ORFNames=G7748;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=S288c / GRF88;
RA   Song J.M., Cheung E., Rabinowitz J.C.;
RT   "Analysis of the 15.6-kb fragment encompassing the ADE3 gene.";
RL   Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8904340;
RX   DOI=10.1002/(sici)1097-0061(19960315)12:3%3c273::aid-yea898%3e3.0.co;2-1;
RA   Guerreiro P., Barreiros T., Soares H., Cyrne L., Maia e Silva A.,
RA   Rodrigues-Pousada C.;
RT   "Sequencing of a 17.6 kb segment on the right arm of yeast chromosome VII
RT   reveals 12 ORFs, including CCT, ADE3 and TR-I genes, homologues of the
RT   yeast PMT and EF1G genes, of the human and bacterial electron-transferring
RT   flavoproteins (beta-chain) and of the Escherichia coli phosphoserine
RT   phosphohydrolase, and five new ORFs.";
RL   Yeast 12:273-280(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169869; DOI=10.1038/387s081;
RA   Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA   Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA   Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA   Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA   Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA   Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA   Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA   Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA   Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA   Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA   Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA   Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA   Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA   Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA   Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA   Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA   Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA   Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA   Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA   Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA   Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA   Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL   Nature 387:81-84(1997).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- MISCELLANEOUS: Present with 11600 molecules/cell in log phase SD
CC       medium. {ECO:0000269|PubMed:14562106}.
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DR   EMBL; U40843; AAA85585.1; -; Genomic_DNA.
DR   EMBL; Z49133; CAA89003.1; -; Genomic_DNA.
DR   EMBL; Z72995; CAA97237.1; -; Genomic_DNA.
DR   EMBL; BK006941; DAA08304.1; -; Genomic_DNA.
DR   PIR; S53933; S53933.
DR   RefSeq; NP_011726.1; NM_001181339.1.
DR   AlphaFoldDB; P42942; -.
DR   SMR; P42942; -.
DR   BioGRID; 33463; 78.
DR   DIP; DIP-2600N; -.
DR   FunCoup; P42942; 78.
DR   IntAct; P42942; 7.
DR   STRING; 4932.YGR210C; -.
DR   iPTMnet; P42942; -.
DR   PaxDb; 4932-YGR210C; -.
DR   PeptideAtlas; P42942; -.
DR   EnsemblFungi; YGR210C_mRNA; YGR210C; YGR210C.
DR   GeneID; 853124; -.
DR   KEGG; sce:YGR210C; -.
DR   AGR; SGD:S000003442; -.
DR   SGD; S000003442; YGR210C.
DR   VEuPathDB; FungiDB:YGR210C; -.
DR   eggNOG; KOG1491; Eukaryota.
DR   HOGENOM; CLU_037276_1_0_1; -.
DR   InParanoid; P42942; -.
DR   OMA; AACMTDF; -.
DR   OrthoDB; 545683at2759; -.
DR   BioCyc; YEAST:G3O-30892-MONOMER; -.
DR   BioGRID-ORCS; 853124; 5 hits in 10 CRISPR screens.
DR   PRO; PR:P42942; -.
DR   Proteomes; UP000002311; Chromosome VII.
DR   RNAct; P42942; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   CDD; cd04938; TGS_Obg; 1.
DR   CDD; cd01899; Ygr210; 1.
DR   FunFam; 1.10.8.470:FF:000001; GTP-binding protein homolog; 1.
DR   FunFam; 3.10.20.30:FF:000037; YGR210C-like protein; 1.
DR   Gene3D; 1.10.8.470; -; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013646; YGR210-like_G4.
DR   PANTHER; PTHR23305; OBG GTPASE FAMILY; 1.
DR   PANTHER; PTHR23305:SF1; OBG-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   Pfam; PF08438; YGR210-like_G4; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51710; G_OBG; 1.
PE   1: Evidence at protein level;
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..411
FT                   /note="Uncharacterized GTP-binding protein YGR210C"
FT                   /id="PRO_0000122467"
FT   DOMAIN          5..274
FT                   /note="OBG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         11..18
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
FT   BINDING         83..87
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01047"
SQ   SEQUENCE   411 AA;  45214 MW;  EDD967C0D6E6D257 CRC64;
     MPRDPLIGIV GKPSSGKSTT LNSLTDAGAA VGAFPFTTIE PNQATGYLQV ECACSRFGKE
     DLCKPNYGWC SKGKRHIPIK LLDVAGLVPG AHSGRGLGNK FLDDLRHADA LIHVVDVSGT
     TDAEGKNTRG YDPLNDIEWL QDEIRLWVEG NLKKRWGSIV RKHTATKSSI VDTLQAQFGG
     YGSHAPMIQK ALDRLKGLPP LEKWDDEWIT RVVKSFMMEK FPTVLALNKI DHPDADKNVS
     KIMLKYPDTK AVLTSAVTEV FLRKLKKQGF ILYEEGTEFV DTFEDEPDKL KPLDDKILNR
     IENIRDLVLY RFGSTGVVQV LQAATDILGL IPVYTVKNIQ TFTGGNGTNV FRDCFLVKRG
     TPVGKVARYI MGGEVTIASI ETVGGVRVSE ESLVEPGKND ILGFKIAPRS A
//