ID   PTPC1_ECOLI             Reviewed;         267 AA.
AC   P42910; Q2M971;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   04-NOV-2026, entry version 154.
DE   RecName: Full=N-acetylgalactosamine permease IIC component 1;
DE   AltName: Full=EIIC-Aga;
DE   AltName: Full=PTS system N-acetylgalactosamine-specific EIIC component 1;
GN   Name=agaC; Synonyms=yraE; OrderedLocusNames=b3139, JW3108;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   DISCUSSION OF SEQUENCE.
RX   PubMed=8932697; DOI=10.1099/13500872-142-2-231;
RA   Reizer J., Ramseier T.M., Reizer A., Charbit A., Saier M.H. Jr.;
RT   "Novel phosphotransferase genes revealed by bacterial genome sequencing: a
RT   gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in
RT   Escherichia coli.";
RL   Microbiology 142:231-250(1996).
RN   [4]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC       system (PTS), a major carbohydrate active -transport system, catalyzes
CC       the phosphorylation of incoming sugar substrates concomitant with their
CC       translocation across the cell membrane. This system is involved in N-
CC       acetylgalactosamine transport.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- DOMAIN: The EIIC domain forms the PTS system translocation channel and
CC       contains the specific substrate-binding site.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U18997; AAA57942.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76173.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77185.1; -; Genomic_DNA.
DR   PIR; G65103; G65103.
DR   RefSeq; NP_417608.1; NC_000913.3.
DR   RefSeq; WP_000544489.1; NZ_CP009789.1.
DR   AlphaFoldDB; P42910; -.
DR   SMR; P42910; -.
DR   BioGRID; 4262422; 14.
DR   FunCoup; P42910; 114.
DR   STRING; 511145.b3139; -.
DR   PaxDb; 511145-b3139; -.
DR   EnsemblBacteria; AAC76173; AAC76173; b3139.
DR   GeneID; 75173312; -.
DR   GeneID; 75203743; -.
DR   GeneID; 947652; -.
DR   KEGG; ecj:JW3108; -.
DR   KEGG; eco:b3139; -.
DR   KEGG; ecoc:C3026_17105; -.
DR   PATRIC; fig|1411691.4.peg.3591; -.
DR   EchoBASE; EB2623; -.
DR   eggNOG; COG3715; Bacteria.
DR   HOGENOM; CLU_069101_2_1_6; -.
DR   InParanoid; P42910; -.
DR   OMA; AAMQVVY; -.
DR   OrthoDB; 3190125at2; -.
DR   PhylomeDB; P42910; -.
DR   BioCyc; EcoCyc:AGAC-MONOMER; -.
DR   PRO; PR:P42910; -.
DR   Proteomes; UP000000625; Chromosome.
DR   AbasyAtlas; P42910; -.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IBA:GO_Central.
DR   InterPro; IPR050303; GatZ_KbaZ_carbometab.
DR   InterPro; IPR004700; PTS_IIC_man.
DR   NCBIfam; NF007289; agaC; 1.
DR   NCBIfam; TIGR00822; EII-Sor; 1.
DR   PANTHER; PTHR32502; N-ACETYLGALACTOSAMINE PERMEASE II COMPONENT-RELATED; 1.
DR   PANTHER; PTHR32502:SF8; N-ACETYLGALACTOSAMINE PERMEASE IIC COMPONENT 1; 1.
DR   Pfam; PF03609; EII-Sor; 1.
DR   PROSITE; PS51106; PTS_EIIC_TYPE_4; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Phosphotransferase system;
KW   Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..267
FT                   /note="N-acetylgalactosamine permease IIC component 1"
FT                   /id="PRO_0000186660"
FT   TOPO_DOM        1..10
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT   TOPO_DOM        32..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT   TOPO_DOM        55..66
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT   TOPO_DOM        88..94
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT   TOPO_DOM        116..141
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT   TOPO_DOM        163..177
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT   TOPO_DOM        199..209
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
FT   TOPO_DOM        231..267
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..237
FT                   /note="PTS EIIC type-4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00429"
SQ   SEQUENCE   267 AA;  28645 MW;  C44F4D0827FE56C6 CRC64;
     MHEITLLQGL SLAALVFVLG IDFWLEALFL FRPIIVCTLT GAILGDIQTG LITGGLTELA
     FAGLTPAGGV QPPNPIMAGL MTTVIAWSTG VDAKTAIGLG LPFSLLMQYV ILFFYSAFSL
     FMTKADKCAK EADTAAFSRL NWTTMLIVAS AYAVIAFLCT YLAQGAMQAL VKAMPAWLTH
     GFEVAGGILP AVGFGLLLRV MFKAQYIPYL IAGFLFVCYI QVSNLLPVAV LGAGFAVYEF
     FNAKSRQQAQ PQPVASKNEE EDYSNGI
//