ID IL4_HORSE Reviewed; 134 AA. AC P42202; O46393; Q9GL85; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 12-APR-2005, sequence version 2. DT 02-SEP-2026, entry version 122. DE RecName: Full=Interleukin-4; DE Short=IL-4; DE AltName: Full=B-cell stimulatory factor 1; DE Short=BSF-1; DE AltName: Full=Lymphocyte stimulatory factor 1; DE Flags: Precursor; GN Name=IL4; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=8042287; DOI=10.1016/0165-2427(94)90047-7; RA Vandergrifft E.V., Swiderski C.E., Horohov D.W.; RT "Molecular cloning and sequencing of equine interleukin 4."; RL Vet. Immunol. Immunopathol. 40:379-384(1994). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Schrenzel M.D., Stannard A.A., Daft B., Ferrick D.A.; RT "Horse (Equus caballus) interleukin-4 gene."; RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Steinbach F., Mauel S.; RT "Cloning of equine interleukin 4 (IL-4)."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Participates in at least several B-cell activation processes CC as well as of other cell types. It is a costimulator of DNA-synthesis. CC It induces the expression of class II MHC molecules on resting B-cells. CC It enhances both secretion and cell surface expression of IgE and IgG1. CC It also regulates the expression of the low affinity Fc receptor for CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates CC IL31RA expression in macrophages. Stimulates autophagy in dendritic CC cells by interfering with mTORC1 signaling and through the induction of CC RUFY4. {ECO:0000250|UniProtKB:P07750}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L06010; AAA21299.1; -; mRNA. DR EMBL; AF035404; AAB87701.1; -; mRNA. DR EMBL; AF305617; AAG21896.1; -; mRNA. DR RefSeq; NP_001075988.2; NM_001082519.2. DR AlphaFoldDB; P42202; -. DR SMR; P42202; -. DR FunCoup; P42202; 738. DR STRING; 9796.ENSECAP00000006431; -. DR GlyCosmos; P42202; 2 sites, No reported glycans. DR PaxDb; 9796-ENSECAP00000006431; -. DR GeneID; 100034225; -. DR KEGG; ecb:100034225; -. DR CTD; 3565; -. DR InParanoid; P42202; -. DR OrthoDB; 9528087at2759; -. DR Proteomes; UP000002281; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008083; F:growth factor activity; IEA:InterPro. DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0035771; P:interleukin-4-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0050728; P:negative regulation of inflammatory response; IBA:GO_Central. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IBA:GO_Central. DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; IBA:GO_Central. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR002354; IL-4. DR InterPro; IPR001325; IL-4/IL-13. DR InterPro; IPR018096; IL-4/IL-13_CS. DR PANTHER; PTHR47401; INTERLEUKIN-4; 1. DR PANTHER; PTHR47401:SF1; INTERLEUKIN-4; 1. DR Pfam; PF00727; IL4; 1. DR PIRSF; PIRSF001941; Interleukin_4; 1. DR PRINTS; PR00431; INTERLEUKIN4. DR SMART; SM00190; IL4_13; 1. DR SUPFAM; SSF47266; 4-helical cytokines; 1. DR PROSITE; PS00838; INTERLEUKIN_4_13; 1. PE 2: Evidence at transcript level; KW B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor; KW Reference proteome; Secreted; Signal. FT SIGNAL 1..23 FT /evidence="ECO:0000250" FT CHAIN 24..134 FT /note="Interleukin-4" FT /id="PRO_0000015531" FT CARBOHYD 38 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 101 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 24..133 FT /evidence="ECO:0000250" FT DISULFID 48..88 FT /evidence="ECO:0000250" FT CONFLICT 5 FT /note="Y -> S (in Ref. 1; AAA21299)" FT /evidence="ECO:0000305" FT CONFLICT 8 FT /note="L -> I (in Ref. 3; AAG21896)" FT /evidence="ECO:0000305" FT CONFLICT 19 FT /note="S -> SN (in Ref. 3; AAG21896)" FT /evidence="ECO:0000305" FT CONFLICT 25 FT /note="K -> I (in Ref. 2; AAB87701)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="K -> I (in Ref. 2; AAB87701)" FT /evidence="ECO:0000305" FT CONFLICT 38 FT /note="N -> NN (in Ref. 3; AAG21896)" FT /evidence="ECO:0000305" FT CONFLICT 58 FT /note="G -> AG (in Ref. 3)" FT /evidence="ECO:0000305" FT CONFLICT 76 FT /note="Q -> QL (in Ref. 3; AAG21896)" FT /evidence="ECO:0000305" FT CONFLICT 96 FT /note="Missing (in Ref. 1; AAA21299)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="Missing (in Ref. 1; AAA21299)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="K -> R (in Ref. 1; AAA21299)" FT /evidence="ECO:0000305" SQ SEQUENCE 134 AA; 14921 MW; CD609F0083B90F32 CRC64; MGLTYQLLPA LVCLLACTSF IQGCKYDITL QEIIKTLNLT DGKGKNSCME LTVADAFGPK NTDGKEICRA AKVLQQYKRH DRSLIKECLS GLDRNLKGMA NGTCCTVNEA KKSTLKDFLE RLKTIMKEKY SKCS //