ID   IFNA1_CHICK             Reviewed;         193 AA.
AC   P42165;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   04-NOV-2026, entry version 158.
DE   RecName: Full=Interferon type A1/A2;
DE   Flags: Precursor;
GN   Name=IFNA1;
GN   and
GN   Name=IFNA2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7521382; DOI=10.1089/jir.1994.14.71;
RA   Sekellick M.J., Ferrandino A.F., Hopkins D.A., Marcus P.I.;
RT   "Chicken interferon gene: cloning, expression, and analysis.";
RL   J. Interferon Res. 14:71-79(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=White leghorn; TISSUE=Spleen;
RX   PubMed=8631799; DOI=10.1074/jbc.271.13.7635;
RA   Sick C., Schultz U., Staeheli P.;
RT   "A family of genes coding for two serologically distinct chicken
RT   interferons.";
RL   J. Biol. Chem. 271:7635-7639(1996).
CC   -!- FUNCTION: Has antiviral activities.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Appears first at 3 hours post-infection, increases
CC       to give the strongest signal at about 9 hours and gradually wanes to
CC       almost nothing at 24 hours.
CC   -!- SIMILARITY: Belongs to the type-I (or alpha/beta) interferon family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01420}.
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DR   EMBL; U07868; AAA50213.1; -; mRNA.
DR   EMBL; X92477; CAA63215.1; -; Genomic_DNA.
DR   EMBL; X92476; CAA63214.1; -; Genomic_DNA.
DR   PIR; I50693; I50693.
DR   RefSeq; NP_990758.1; NM_205427.1.
DR   AlphaFoldDB; P42165; -.
DR   SMR; P42165; -.
DR   FunCoup; P42165; 90.
DR   STRING; 9031.ENSGALP00000069151; -.
DR   GlyCosmos; P42165; 4 sites, No reported glycans.
DR   GlyGen; P42165; 5 sites.
DR   PaxDb; 9031-ENSGALP00000069151; -.
DR   GeneID; 396398; -.
DR   KEGG; gga:100857744; -.
DR   KEGG; gga:396398; -.
DR   CTD; 396398; -.
DR   VEuPathDB; HostDB:geneid_396398; -.
DR   eggNOG; ENOG502SQGR; Eukaryota.
DR   HOGENOM; CLU_109427_1_0_1; -.
DR   InParanoid; P42165; -.
DR   OMA; ACAWDHI; -.
DR   OrthoDB; 9110568at2759; -.
DR   PhylomeDB; P42165; -.
DR   PRO; PR:P42165; -.
DR   Proteomes; UP000000539; Chromosome Z.
DR   Bgee; ENSGALG00000046996; Expressed in brain and 3 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0002312; P:B cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0009615; P:response to virus; IEA:UniProtKB-ARBA.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; IBA:GO_Central.
DR   CDD; cd00095; IFab; 1.
DR   FunFam; 1.20.1250.10:FF:000046; Interferon alpha; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_I.
DR   PANTHER; PTHR11691:SF73; INTERFERON BETA; 1.
DR   PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS52075; IFN_I; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..193
FT                   /note="Interferon type A1/A2"
FT                   /id="PRO_0000016428"
FT   CARBOHYD        65
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        108
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        186
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        32..129
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01420"
FT   DISULFID        61..168
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01420"
FT   DISULFID        68..155
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01420"
FT   VARIANT         65
FT                   /note="N -> S"
SQ   SEQUENCE   193 AA;  22116 MW;  35AF74479C450A15 CRC64;
     MAVPASPQHP RGYGILLLTL LLKALATTAS ACNHLRPQDA TFSHDSLQLL RDMAPTLPQL
     CPQHNASCSF NDTILDTSNT RQADKTTHDI LQHLFKILSS PSTPAHWNDS QRQSLLNRIH
     RYTQHLEQCL DSSDTRSRTR WPRNLHLTIK KHFSCLHTFL QDNDYSACAW EHVRLQARAW
     FLHIHNLTGN TRT
//