ID PRGK_SALTY Reviewed; 252 AA. AC P41786; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 1. DT 04-NOV-2026, entry version 134. DE RecName: Full=Lipoprotein PrgK; DE Flags: Precursor; GN Name=prgK; OrderedLocusNames=STM2871; OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720). OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; OC Enterobacterales; Enterobacteriaceae; Salmonella. OX NCBI_TaxID=99287; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 14028s / SGSG 2262; RX PubMed=7476203; DOI=10.1111/j.1365-2958.1995.mmi_17010169.x; RA Pegues D.A., Hantman M.J., Behlau I., Miller S.I.; RT "PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion RT genes: evidence for a role in protein secretion."; RL Mol. Microbiol. 17:169-181(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LT2 / SGSC1412 / ATCC 700720; RX PubMed=11677609; DOI=10.1038/35101614; RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E., RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., RA Wilson R.K.; RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."; RL Nature 413:852-856(2001). CC -!- FUNCTION: Required for invasion of epithelial cells. Could be involved CC in protein secretion. CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor CC {ECO:0000305}. CC -!- SIMILARITY: Belongs to the YscJ lipoprotein family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U21676; AAB60191.1; -; Genomic_DNA. DR EMBL; AE006468; AAL21751.1; -; Genomic_DNA. DR PIR; S69786; S69786. DR RefSeq; NP_461792.1; NC_003197.2. DR RefSeq; WP_000621238.1; NC_003197.2. DR PDB; 2Y9J; EM; 6.40 A; Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v=21-190. DR PDB; 3J6D; EM; -; Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v=1-252. DR PDB; 4OYC; X-ray; 2.60 A; A/B=96-200. DR PDB; 4W4M; X-ray; 3.20 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=19-92. DR PDB; 5TCP; EM; 4.30 A; 0/2/4/6/8/B/D/F/H/J/L/N/P/R/T/V/X/Z/a/c/e/g/i/k=18-252. DR PDB; 5TCR; EM; 6.30 A; 1/3/5/7/9/P/R/T/V/X/a/c/e/g/i/k/m/o/q/s/u/w/y/z=18-252. DR PDB; 6DUZ; EM; 3.60 A; Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v=1-252. DR PDB; 6PEM; EM; 3.50 A; AA/AB/AC/AD/AE/AF/AG/AH/AI/AJ/AK/AL/o/p/q/r/s/t/u/v/w/x/y/z=1-252. DR PDB; 6Q14; EM; 3.80 A; AA/AB/AC/AD/AE/AF/AG/AH/AI/AJ/AK/AL/o/p/q/r/s/t/u/v/w/x/y/z=1-252. DR PDB; 6Q15; EM; 5.15 A; AA/AB/AC/AD/AE/AF/AG/AH/AI/AJ/AK/AL/o/p/q/r/s/t/u/v/w/x/y/z=1-252. DR PDB; 6Q16; EM; 4.10 A; AA/AB/AC/AD/AE/AF/AG/AH/AI/AJ/AK/AL/o/p/q/r/s/t/u/v/w/x/y/z=1-252. DR PDB; 6UOT; EM; 3.30 A; Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v=1-252. DR PDB; 6UOV; EM; 3.50 A; A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e/g/i/k/m/o/q/s=1-252. DR PDB; 7AH9; EM; 3.30 A; 6A/6B/6C/6D/6E/6F/6G/6H/6I/6J/6K/6L/6M/6N/6O/6P/6Q/6R/6S/6T/6U/6V/6W/6X=1-252. DR PDB; 7AHI; EM; 3.30 A; 6A/6B/6C/6D/6E/6F/6G/6H/6I/6J/6K/6L/6M/6N/6O/6P/6Q/6R/6S/6T/6U/6V/6W/6X=1-252. DR AlphaFoldDB; P41786; -. DR BMRB; P41786; -. DR EMDB; EMD-11781; -. DR EMDB; EMD-20556; -. DR EMDB; EMD-20832; -. DR EMDB; EMD-20833; -. DR EMDB; EMD-8398; -. DR EMDB; EMD-8400; -. DR EMDB; EMD-8913; -. DR MDposit; P41786; -. DR SMR; P41786; -. DR DIP; DIP-59554N; -. DR IntAct; P41786; 2. DR STRING; 99287.STM2871; -. DR TCDB; 3.A.6.1.3; the type iii (virulence-related) secretory pathway (iiisp) family. DR PaxDb; 99287-STM2871; -. DR GeneID; 1254394; -. DR KEGG; stm:STM2871; -. DR PATRIC; fig|99287.12.peg.3027; -. DR HOGENOM; CLU_073268_2_0_6; -. DR OMA; AAVYWIK; -. DR PhylomeDB; P41786; -. DR BioCyc; SENT99287:STM2871-MONOMER; -. DR EvolutionaryTrace; P41786; -. DR Proteomes; UP000001014; Chromosome. DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell. DR GO; GO:0009306; P:protein secretion; IEA:InterPro. DR Gene3D; 3.30.300.30; -; 1. DR Gene3D; 3.30.70.1530; Hypothetical protein rpa1041; 1. DR InterPro; IPR045851; AMP-b_sf. DR InterPro; IPR006182; FliF_N_dom. DR InterPro; IPR003282; T3SS_SctJ. DR InterPro; IPR043427; YscJ/FliF. DR NCBIfam; TIGR02544; III_secr_YscJ; 1. DR NCBIfam; NF011852; PRK15324.1; 1. DR PANTHER; PTHR30046; FLAGELLAR M-RING PROTEIN; 1. DR PANTHER; PTHR30046:SF3; SECRETION SYSTEM APPARATUS LIPOPROTEIN SSAJ; 1. DR Pfam; PF01514; YscJ_FliF; 1. DR PRINTS; PR01338; TYPE3OMKPROT. DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1. PE 1: Evidence at protein level; KW 3D-structure; Cell outer membrane; Lipoprotein; Membrane; Palmitate; KW Protein transport; Reference proteome; Signal; Transmembrane; KW Transmembrane helix; Transport; Virulence. FT SIGNAL 1..17 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303" FT CHAIN 18..252 FT /note="Lipoprotein PrgK" FT /id="PRO_0000018182" FT TRANSMEM 207..227 FT /note="Helical" FT /evidence="ECO:0000255" FT LIPID 18 FT /note="N-palmitoyl cysteine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303" FT LIPID 18 FT /note="S-diacylglycerol cysteine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303" FT STRAND 20..27 FT /evidence="ECO:0007829|PDB:4W4M" FT HELIX 29..40 FT /evidence="ECO:0007829|PDB:4W4M" FT TURN 41..43 FT /evidence="ECO:0007829|PDB:4W4M" FT STRAND 47..50 FT /evidence="ECO:0007829|PDB:4W4M" FT HELIX 52..54 FT /evidence="ECO:0007829|PDB:4W4M" FT STRAND 56..61 FT /evidence="ECO:0007829|PDB:4W4M" FT HELIX 62..64 FT /evidence="ECO:0007829|PDB:4W4M" FT HELIX 65..74 FT /evidence="ECO:0007829|PDB:4W4M" FT HELIX 79..83 FT /evidence="ECO:0007829|PDB:7AH9" FT HELIX 85..87 FT /evidence="ECO:0007829|PDB:6UOT" FT STRAND 93..95 FT /evidence="ECO:0007829|PDB:6UOT" FT HELIX 98..117 FT /evidence="ECO:0007829|PDB:4OYC" FT STRAND 120..122 FT /evidence="ECO:0007829|PDB:6UOV" FT STRAND 123..131 FT /evidence="ECO:0007829|PDB:4OYC" FT HELIX 133..135 FT /evidence="ECO:0007829|PDB:7AH9" FT TURN 136..138 FT /evidence="ECO:0007829|PDB:6UOT" FT HELIX 141..146 FT /evidence="ECO:0007829|PDB:6UOT" FT STRAND 147..154 FT /evidence="ECO:0007829|PDB:4OYC" FT HELIX 160..174 FT /evidence="ECO:0007829|PDB:4OYC" FT STRAND 175..177 FT /evidence="ECO:0007829|PDB:6UOT" FT HELIX 180..182 FT /evidence="ECO:0007829|PDB:4OYC" FT STRAND 183..188 FT /evidence="ECO:0007829|PDB:4OYC" FT HELIX 190..193 FT /evidence="ECO:0007829|PDB:6UOT" FT HELIX 197..201 FT /evidence="ECO:0007829|PDB:7AH9" SQ SEQUENCE 252 AA; 28210 MW; 2C0A6FC06667E256 CRC64; MIRRYLYTFL LVMTLAGCKD KDLLKGLDQE QANEVIAVLQ MHNIEANKID SGKLGYSITV AEPDFTAAVY WIKTYQLPPR PRVEIAQMFP ADSLVSSPRA EKARLYSAIE QRLEQSLQTM EGVLSARVHI SYDIDAGENG RPPKPVHLSA LAVYERGSPL AHQISDIKRF LKNSFADVDY DNISVVLSER SDAQLQAPGT PVKRNSFATS WIVLIILLSV MSAGFGVWYY KNHYARNKKG ITADDKAKSS NE //