ID   TSN7_HUMAN              Reviewed;         249 AA.
AC   P41732; B2R5W7; D3DWB1; Q8WVG5; Q9UEY9;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 2.
DT   02-SEP-2026, entry version 211.
DE   RecName: Full=Tetraspanin-7;
DE            Short=Tspan-7;
DE   AltName: Full=Cell surface glycoprotein A15;
DE   AltName: Full=Membrane component chromosome X surface marker 1;
DE   AltName: Full=T-cell acute lymphoblastic leukemia-associated antigen 1;
DE            Short=TALLA-1;
DE   AltName: Full=Transmembrane 4 superfamily member 2;
DE   AltName: CD_antigen=CD231;
GN   Name=TSPAN7; Synonyms=A15, DXS1692E, MXS1, TM4SF2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Peripheral blood lymphocyte;
RX   PubMed=8420826; DOI=10.1007/bf00191884;
RA   Emi N., Kitaori K., Seto M., Ueda R., Saito H., Takahashi T.;
RT   "Isolation of a novel cDNA clone showing marked similarity to ME491/CD63
RT   superfamily.";
RL   Immunogenetics 37:193-198(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 4-249.
RC   TISSUE=Peripheral blood;
RX   PubMed=7768645; DOI=10.1002/ijc.2910610519;
RA   Takagi S., Fujikawa K., Imai T., Fukuhara N., Fukudome K., Minegishi M.,
RA   Tsuchiya S., Konno T., Hinuma Y., Yoshie O.;
RT   "Identification of a highly specific surface marker of T-cell acute
RT   lymphoblastic leukemia and neuroblastoma as a new member of the
RT   transmembrane 4 superfamily.";
RL   Int. J. Cancer 61:706-715(1995).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT XLID58 HIS-172.
RX   PubMed=10655063; DOI=10.1038/72829;
RA   Zemni R., Bienvenu T., Vinet M.C., Sefiani A., Carrie A., Billuart P.,
RA   McDonell N., Couvert P., Francis F., Chafey P., Fauchereau F.,
RA   Friocourt G., desPortes V., Cardona A., Frints S., Meindl A., Brandau O.,
RA   Ronce N., Moraine C., Bokhoven H.V., Ropers H.-H., Sudbrak R., Kahn A.,
RA   Fryns J.-P., Beldjord C., Chelly J.;
RT   "A new gene involved in X-linked mental retardation identified by analysis
RT   of an X;2 balanced translocation.";
RL   Nat. Genet. 24:167-170(2000).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Wang H., Gao X., Huang Y., Han J.;
RT   "Homo sapiens transmembrane 4 superfamily member 2 (TM4SF2, tetraspanins),
RT   mRNA.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LYS-53 AND THR-127.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   INTERACTION WITH HHV-1 UL35 (MICROBIAL INFECTION).
RX   PubMed=20630051; DOI=10.1186/1743-422x-7-156;
RA   Wang L., Liu L., Che Y., Wang L., Jiang L., Dong C., Zhang Y., Li Q.;
RT   "Egress of HSV-1 capsid requires the interaction of VP26 and a cellular
RT   tetraspanin membrane protein.";
RL   Virol. J. 7:156-156(2010).
CC   -!- FUNCTION: May be involved in cell proliferation and cell motility.
CC   -!- SUBUNIT: (Microbial infection) Interacts with herpes simplex virus 1
CC       (HHV-1) UL35. {ECO:0000269|PubMed:20630051}.
CC   -!- INTERACTION:
CC       P41732; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-1042779, EBI-18304435;
CC       P41732; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-1042779, EBI-13345167;
CC       P41732; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-1042779, EBI-2820517;
CC       P41732; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-1042779, EBI-16439278;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Not solely expressed in T-cells. Expressed in acute
CC       myelocytic leukemia cells of some patients.
CC   -!- DISEASE: Intellectual developmental disorder, X-linked 58 (XLID58)
CC       [MIM:300210]: A disorder characterized by significantly below average
CC       general intellectual functioning associated with impairments in
CC       adaptive behavior and manifested during the developmental period.
CC       Intellectual deficiency is the only primary symptom of non-syndromic X-
CC       linked intellectual disability, while syndromic intellectual disability
CC       presents with associated physical, neurological and/or psychiatric
CC       manifestations. {ECO:0000269|PubMed:10655063}. Note=The disease is
CC       caused by variants affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA01501.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAA06191.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D10653; BAA01501.1; ALT_INIT; mRNA.
DR   EMBL; AK312343; BAG35264.1; -; mRNA.
DR   EMBL; CH471141; EAW59437.1; -; Genomic_DNA.
DR   EMBL; D29808; BAA06191.1; ALT_INIT; mRNA.
DR   EMBL; AJ250562; CAB65594.1; -; Genomic_DNA.
DR   EMBL; AJ250563; CAB65594.1; JOINED; Genomic_DNA.
DR   EMBL; AJ250564; CAB65594.1; JOINED; Genomic_DNA.
DR   EMBL; AJ250565; CAB65594.1; JOINED; Genomic_DNA.
DR   EMBL; AJ250566; CAB65594.1; JOINED; Genomic_DNA.
DR   EMBL; AJ250567; CAB65594.1; JOINED; Genomic_DNA.
DR   EMBL; AJ250568; CAB65594.1; JOINED; Genomic_DNA.
DR   EMBL; AB062057; BAB55825.1; -; mRNA.
DR   EMBL; AB062057; BAB55824.1; -; mRNA.
DR   EMBL; CH471141; EAW59438.1; -; Genomic_DNA.
DR   EMBL; BC018036; AAH18036.1; -; mRNA.
DR   CCDS; CCDS14248.1; -.
DR   PIR; I39368; I39368.
DR   RefSeq; NP_004606.2; NM_004615.4.
DR   AlphaFoldDB; P41732; -.
DR   SMR; P41732; -.
DR   BioGRID; 112957; 37.
DR   FunCoup; P41732; 473.
DR   IntAct; P41732; 23.
DR   MINT; P41732; -.
DR   STRING; 9606.ENSP00000367743; -.
DR   TCDB; 8.A.40.1.2; the tetraspanin (tetraspanin) family.
DR   GlyCosmos; P41732; 5 sites, No reported glycans.
DR   GlyGen; P41732; 5 sites.
DR   iPTMnet; P41732; -.
DR   PhosphoSitePlus; P41732; -.
DR   SwissPalm; P41732; -.
DR   BioMuta; TSPAN7; -.
DR   DMDM; 17380550; -.
DR   jPOST; P41732; -.
DR   MassIVE; P41732; -.
DR   PaxDb; 9606-ENSP00000367743; -.
DR   PeptideAtlas; P41732; -.
DR   ProteomicsDB; 55476; -.
DR   Pumba; P41732; -.
DR   Antibodypedia; 530; 303 antibodies from 30 providers.
DR   DNASU; 7102; -.
DR   Ensembl; ENST00000378482.7; ENSP00000367743.2; ENSG00000156298.14.
DR   Ensembl; ENST00000899436.1; ENSP00000569495.1; ENSG00000156298.14.
DR   Ensembl; ENST00000899437.1; ENSP00000569496.1; ENSG00000156298.14.
DR   Ensembl; ENST00000899441.1; ENSP00000569500.1; ENSG00000156298.14.
DR   Ensembl; ENST00000899442.1; ENSP00000569501.1; ENSG00000156298.14.
DR   GeneID; 7102; -.
DR   KEGG; hsa:7102; -.
DR   MANE-Select; ENST00000378482.7; ENSP00000367743.2; NM_004615.4; NP_004606.2.
DR   UCSC; uc004deg.5; human.
DR   AGR; HGNC:11854; -.
DR   ClinPGx; PA36555; -.
DR   CTD; 7102; -.
DR   DisGeNET; 7102; -.
DR   GeneCards; TSPAN7; -.
DR   HGNC; HGNC:11854; TSPAN7.
DR   HPA; ENSG00000156298; Tissue enhanced (brain).
DR   MalaCards; TSPAN7; -.
DR   MIM; 300096; gene.
DR   MIM; 300210; phenotype.
DR   OpenTargets; ENSG00000156298; -.
DR   Orphanet; 777; X-linked non-syndromic intellectual disability.
DR   VEuPathDB; HostDB:ENSG00000156298; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   GeneTree; ENSGT00940000156153; -.
DR   HOGENOM; CLU_055524_3_0_1; -.
DR   InParanoid; P41732; -.
DR   OMA; VYRQGCY; -.
DR   OrthoDB; 9972904at2759; -.
DR   PAN-GO; P41732; 1 GO annotation based on evolutionary models.
DR   PhylomeDB; P41732; -.
DR   PathwayCommons; P41732; -.
DR   Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR   Reactome; R-HSA-416993; Trafficking of GluR2-containing AMPA receptors.
DR   SignaLink; P41732; -.
DR   SIGNOR; P41732; -.
DR   Agora; ENSG00000156298; Agora Nominated Target for Alzheimer's Disease.
DR   BioGRID-ORCS; 7102; 10 hits in 772 CRISPR screens.
DR   ChiTaRS; TSPAN7; human.
DR   GeneWiki; TSPAN7; -.
DR   GenomeRNAi; 7102; -.
DR   Pharos; P41732; Tbio.
DR   PRO; PR:P41732; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; P41732; protein.
DR   Bgee; ENSG00000156298; Expressed in caudate nucleus and 198 other cell types or tissues.
DR   ExpressionAtlas; P41732; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   CDD; cd03161; TM4SF2_6_like_LEL; 1.
DR   FunFam; 1.10.1450.10:FF:000003; Tetraspanin; 1.
DR   Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   InterPro; IPR048232; TSN6/7_LEL.
DR   PANTHER; PTHR19282; TETRASPANIN; 1.
DR   PANTHER; PTHR19282:SF257; TETRASPANIN-7; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
KW   Disease variant; Glycoprotein; Host-virus interaction;
KW   Intellectual disability; Membrane; Proteomics identification;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..249
FT                   /note="Tetraspanin-7"
FT                   /id="PRO_0000219248"
FT   TOPO_DOM        1..16
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        17..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..56
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..213
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..249
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        155
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        158
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        177
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         53
FT                   /note="E -> K (in dbSNP:rs17851592)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037905"
FT   VARIANT         127
FT                   /note="A -> T (in dbSNP:rs17851593)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037906"
FT   VARIANT         172
FT                   /note="P -> H (in XLID58; dbSNP:rs104894951)"
FT                   /evidence="ECO:0000269|PubMed:10655063"
FT                   /id="VAR_009259"
FT   CONFLICT        136
FT                   /note="E -> K (in Ref. 5; CAB65594)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   249 AA;  27574 MW;  F2CF4517DB388173 CRC64;
     MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL IAENSTNAPY
     VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL AELVAGISGF VFRHEIKDTF
     LRTYTDAMQT YNGNDERSRA VDHVQRSLSC CGVQNYTNWS TSPYFLEHGI PPSCCMNETD
     CNPQDLHNLT VAATKVNQKG CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF
     ITANQYEMV
//