ID   YJV8_YEAST              Reviewed;         196 AA.
AC   P40892; D6VVX8;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   04-NOV-2026, entry version 161.
DE   RecName: Full=Putative acetyltransferase YJL218W {ECO:0000305};
DE            EC=2.3.1.-;
GN   OrderedLocusNames=YJL218W; ORFNames=HRA196, J0224;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7725802; DOI=10.1002/yea.320101216;
RA   Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.;
RT   "Sequence analysis of a 40.2 kb DNA fragment located near the left telomere
RT   of yeast chromosome X.";
RL   Yeast 10:1657-1662(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P77791}.
CC   -!- INTERACTION:
CC       P40892; P39940: RSP5; NbExp=2; IntAct=EBI-26263, EBI-16219;
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; Z34098; CAA83992.1; -; Genomic_DNA.
DR   EMBL; Z49493; CAA89515.1; -; Genomic_DNA.
DR   EMBL; AY692672; AAT92691.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08594.1; -; Genomic_DNA.
DR   PIR; S50709; S50709.
DR   RefSeq; NP_012317.1; NM_001181651.1.
DR   AlphaFoldDB; P40892; -.
DR   SMR; P40892; -.
DR   BioGRID; 33563; 39.
DR   DIP; DIP-1828N; -.
DR   FunCoup; P40892; 54.
DR   IntAct; P40892; 8.
DR   STRING; 4932.YJL218W; -.
DR   iPTMnet; P40892; -.
DR   PaxDb; 4932-YJL218W; -.
DR   PeptideAtlas; P40892; -.
DR   EnsemblFungi; YJL218W_mRNA; YJL218W; YJL218W.
DR   GeneID; 853237; -.
DR   KEGG; sce:YJL218W; -.
DR   AGR; SGD:S000003754; -.
DR   SGD; S000003754; YJL218W.
DR   VEuPathDB; FungiDB:YJL218W; -.
DR   eggNOG; KOG4750; Eukaryota.
DR   HOGENOM; CLU_051638_3_0_1; -.
DR   InParanoid; P40892; -.
DR   OMA; AAHRKAC; -.
DR   OrthoDB; 25818at2759; -.
DR   BioGRID-ORCS; 853237; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P40892; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; P40892; protein.
DR   GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR   GO; GO:0008870; F:galactoside O-acetyltransferase activity; IBA:GO_Central.
DR   CDD; cd03357; LbH_MAT_GAT; 1.
DR   FunFam; 2.160.10.10:FF:000008; Maltose O-acetyltransferase; 1.
DR   Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR039369; LacA-like.
DR   InterPro; IPR024688; Mac_dom.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   PANTHER; PTHR43017:SF1; ACETYLTRANSFERASE YJL218W-RELATED; 1.
DR   PANTHER; PTHR43017; GALACTOSIDE O-ACETYLTRANSFERASE; 1.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF12464; Mac; 1.
DR   SMART; SM01266; Mac; 1.
DR   SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   1: Evidence at protein level;
KW   Acyltransferase; Reference proteome; Repeat; Transferase.
FT   CHAIN           1..196
FT                   /note="Putative acetyltransferase YJL218W"
FT                   /id="PRO_0000068743"
FT   ACT_SITE        114
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P07464"
FT   BINDING         84
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250|UniProtKB:P07464"
FT   BINDING         141
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250|UniProtKB:P07464"
FT   BINDING         159
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250|UniProtKB:P07464"
FT   BINDING         164..165
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250|UniProtKB:P07464"
FT   BINDING         179
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250|UniProtKB:P07464"
FT   BINDING         182
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250|UniProtKB:P07464"
FT   SITE            84
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000250|UniProtKB:P07464"
SQ   SEQUENCE   196 AA;  21480 MW;  FDE9036757112E84 CRC64;
     MGVLENIVPG ELYDANYDPD LLKIRKETKI KLHEYNTLSP ADENKKSQVI RELLGSCTDN
     FIIEPPFYCD YGSNIYIGDN FYANHNLVIL DGAKVVIGDN VFIAPNVGIY TAGHPIDVER
     RLQGLEYAMP VTIGDNVWIG GGVSIIPGVN IGKNSVIAAG SVVIRDIPEN VVAAGNPCKV
     IRKITEKDST TTNYRK
//