ID   YAP5_YEAST              Reviewed;         245 AA.
AC   P40574; D6VVU8;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   02-SEP-2026, entry version 186.
DE   RecName: Full=AP-1-like transcription factor YAP5;
GN   Name=YAP5; OrderedLocusNames=YIR018W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 28383 / FL100 / VTT C-80102;
RX   PubMed=8665859; DOI=10.1002/j.1460-2075.1996.tb00609.x;
RA   Kuras L., Cherest H., Surdin-Kerjan Y., Thomas D.;
RT   "A heteromeric complex containing the centromere binding factor 1 and two
RT   basic leucine zipper factors, Met4 and Met28, mediates the transcription
RT   activation of yeast sulfur metabolism.";
RL   EMBO J. 15:2519-2529(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169870; DOI=10.1038/387s084;
RA   Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA   Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA   Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA   Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA   Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL   Nature 387:84-87(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   FUNCTION, AND ISOLATION OF YAP FAMILY PROTEINS.
RX   PubMed=9372930; DOI=10.1128/mcb.17.12.6982;
RA   Fernandes L., Rodrigues-Pousada C., Struhl K.;
RT   "Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae
RT   with distinct biological functions.";
RL   Mol. Cell. Biol. 17:6982-6993(1997).
RN   [6]
RP   FUNCTION, AND CELL CYCLE ACTIVATION.
RX   PubMed=12464632; DOI=10.1101/gad.1039602;
RA   Horak C.E., Luscombe N.M., Qian J., Bertone P., Piccirrillo S.,
RA   Gerstein M., Snyder M.;
RT   "Complex transcriptional circuitry at the G1/S transition in Saccharomyces
RT   cerevisiae.";
RL   Genes Dev. 16:3017-3033(2002).
RN   [7]
RP   FUNCTION, AND REGULATORY TRANSCRIPTION MODULES.
RX   PubMed=14555958; DOI=10.1038/nbt890;
RA   Bar-Joseph Z., Gerber G.K., Lee T.I., Rinaldi N.J., Yoo J.Y., Robert F.,
RA   Gordon D.B., Fraenkel E., Jaakkola T.S., Young R.A., Gifford D.K.;
RT   "Computational discovery of gene modules and regulatory networks.";
RL   Nat. Biotechnol. 21:1337-1342(2003).
RN   [8]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [9]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Transcription activator involved in the regulation of genes
CC       expressed in response to environmental changes and metabolic
CC       requirements. According to genome-wide promoter binding and gene
CC       expression studies it is a coregulator for the expression of ribosomal
CC       genes, while its own expression is induced by the cell cycle specific
CC       activator SBF (SWI4-SWI6). {ECO:0000269|PubMed:12464632,
CC       ECO:0000269|PubMed:14555958, ECO:0000269|PubMed:9372930}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: One of 8 closely related fungi-specific YAP proteins
CC       (YAP1 to YAP8), which all seem to be transcription activators of the
CC       environmental stress response and metabolism control pathways and to
CC       have similar but not identical DNA binding specificities.
CC   -!- MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the bZIP family. YAP subfamily. {ECO:0000305}.
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DR   EMBL; U17015; AAC49426.1; -; Genomic_DNA.
DR   EMBL; Z37996; CAA86089.1; -; Genomic_DNA.
DR   EMBL; AY558238; AAS56564.1; -; Genomic_DNA.
DR   EMBL; BK006942; DAA08564.1; -; Genomic_DNA.
DR   PIR; S48363; S48363.
DR   RefSeq; NP_012283.1; NM_001179540.1.
DR   AlphaFoldDB; P40574; -.
DR   SMR; P40574; -.
DR   BioGRID; 35010; 46.
DR   DIP; DIP-2994N; -.
DR   FunCoup; P40574; 970.
DR   IntAct; P40574; 6.
DR   MINT; P40574; -.
DR   STRING; 4932.YIR018W; -.
DR   iPTMnet; P40574; -.
DR   PaxDb; 4932-YIR018W; -.
DR   PeptideAtlas; P40574; -.
DR   EnsemblFungi; YIR018W_mRNA; YIR018W; YIR018W.
DR   GeneID; 854835; -.
DR   KEGG; sce:YIR018W; -.
DR   AGR; SGD:S000001457; -.
DR   SGD; S000001457; YAP5.
DR   VEuPathDB; FungiDB:YIR018W; -.
DR   eggNOG; ENOG502QUE5; Eukaryota.
DR   HOGENOM; CLU_963771_0_0_1; -.
DR   InParanoid; P40574; -.
DR   OMA; SHERAKP; -.
DR   OrthoDB; 2285533at2759; -.
DR   BioCyc; YEAST:G3O-31438-MONOMER; -.
DR   BioGRID-ORCS; 854835; 4 hits in 10 CRISPR screens.
DR   PRO; PR:P40574; -.
DR   Proteomes; UP000002311; Chromosome IX.
DR   RNAct; P40574; protein.
DR   GO; GO:0000785; C:chromatin; IDA:SGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:SGD.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR   GO; GO:0071281; P:cellular response to iron ion; IMP:SGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:SGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:SGD.
DR   CDD; cd14688; bZIP_YAP; 1.
DR   Gene3D; 1.20.5.170; -; 1.
DR   InterPro; IPR050936; AP-1-like.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   PANTHER; PTHR40621:SF6; AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED; 1.
DR   PANTHER; PTHR40621; TRANSCRIPTION FACTOR KAPC-RELATED; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; Leucine zipper domain; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   1: Evidence at protein level;
KW   Activator; Cytoplasm; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..245
FT                   /note="AP-1-like transcription factor YAP5"
FT                   /id="PRO_0000076525"
FT   DOMAIN          58..121
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          34..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          63..82
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          86..114
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   COMPBIAS        34..47
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        173
FT                   /note="P -> S (in Ref. 1; AAC49426)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   245 AA;  28386 MW;  02F78E1963982E0D CRC64;
     MALPLIKPKE SEESHLALLS KIHVSKNWKL PPRLPHRAAQ RRKRVHRLHE DYETEENDEE
     LQKKKRQNRD AQRAYRERKN NKLQVLEETI ESLSKVVKNY ETKLNRLQNE LQAKESENHA
     LKQKLETLTL KQASVPAQDP ILQNLIENFK PMKAIPIKYN TAIKRHQHST ELPSSVKCGF
     CNDNTTCVCK ELETDHRKSD DGVATEQKDM SMPHAECNNK DNPNGLCSNC TNIDKSCIDI
     RSIIH
//