ID UTP7_YEAST Reviewed; 554 AA. AC P40055; D3DLY9; DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1995, sequence version 1. DT 04-NOV-2026, entry version 195. DE RecName: Full=U3 small nucleolar RNA-associated protein 7; DE Short=U3 snoRNA-associated protein 7; DE AltName: Full=U three protein 7; GN Name=UTP7; Synonyms=KRE31; OrderedLocusNames=YER082C; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=9169868; DOI=10.1038/387s078; RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., RA Botstein D., Davis R.W.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V."; RL Nature 387:78-81(1997). RN [2] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RX PubMed=24374639; DOI=10.1534/g3.113.008995; RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.; RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now."; RL G3 (Bethesda) 4:389-398(2014). RN [3] RP FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU RP PROCESSOME BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION. RX PubMed=12068309; DOI=10.1038/nature00769; RA Dragon F., Gallagher J.E.G., Compagnone-Post P.A., Mitchell B.M., RA Porwancher K.A., Wehner K.A., Wormsley S., Settlage R.E., Shabanowitz J., RA Osheim Y., Beyer A.L., Hunt D.F., Baserga S.J.; RT "A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA RT biogenesis."; RL Nature 417:967-970(2002). RN [4] RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. RX PubMed=14562106; DOI=10.1038/nature02046; RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., RA O'Shea E.K., Weissman J.S.; RT "Global analysis of protein expression in yeast."; RL Nature 425:737-741(2003). CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA. CC {ECO:0000269|PubMed:12068309}. CC -!- SUBUNIT: Interacts with snoRNA U3. Interacts with MPP10. Component of CC the ribosomal small subunit (SSU) processome composed of at least 40 CC protein subunits and snoRNA U3. {ECO:0000269|PubMed:12068309}. CC -!- INTERACTION: CC P40055; P42945: UTP10; NbExp=7; IntAct=EBI-22597, EBI-1884; CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12068309}. CC -!- MISCELLANEOUS: Present with 5800 molecules/cell in log phase SD medium. CC {ECO:0000269|PubMed:14562106}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U18839; AAB64637.1; -; Genomic_DNA. DR EMBL; BK006939; DAA07743.1; -; Genomic_DNA. DR PIR; S50585; S50585. DR RefSeq; NP_011005.1; NM_001178973.1. DR PDB; 5WLC; EM; 3.80 A; LW=1-554. DR PDB; 6KE6; EM; 3.40 A; 5C=1-554. DR PDB; 6LQP; EM; 3.20 A; 5C=1-554. DR PDB; 6LQQ; EM; 4.10 A; 5C=1-554. DR PDB; 6LQR; EM; 8.60 A; 5C=1-554. DR PDB; 6LQS; EM; 3.80 A; 5C=1-554. DR PDB; 6LQT; EM; 4.90 A; 5C=1-554. DR PDB; 6LQU; EM; 3.70 A; 5C=1-554. DR PDB; 6LQV; EM; 4.80 A; 5C=1-554. DR PDB; 6ND4; EM; 4.30 A; W=1-554. DR PDB; 6ZQA; EM; 4.40 A; UG=1-554. DR PDB; 6ZQB; EM; 3.90 A; UG=1-554. DR PDB; 6ZQC; EM; 3.80 A; UG=1-554. DR PDB; 6ZQD; EM; 3.80 A; UG=1-554. DR PDB; 7AJT; EM; 4.60 A; UG=1-554. DR PDB; 7AJU; EM; 3.80 A; UG=1-554. DR PDB; 7D4I; EM; 4.00 A; 5C=1-554. DR PDB; 7D5S; EM; 4.60 A; 5C=1-554. DR PDB; 7D5T; EM; 6.00 A; 5C=1-554. DR PDB; 7D63; EM; 12.30 A; 5C=1-554. DR PDB; 7SUK; EM; 3.99 A; LW=36-473. DR PDB; 9G33; EM; 3.05 A; UG=1-554. DR PDB; 9N6V; EM; 3.16 A; LW=1-554. DR PDB; 9N6W; EM; 3.05 A; LW=1-554. DR PDB; 9N6X; EM; 3.71 A; LW=1-554. DR PDB; 9N6Y; EM; 3.65 A; LW=1-554. DR PDB; 9N6Z; EM; 4.74 A; LW=1-554. DR PDB; 9N70; EM; 5.17 A; LW=1-554. DR PDB; 9N72; EM; 5.94 A; LW=1-554. DR PDB; 9N73; EM; 5.96 A; LW=1-554. DR PDB; 9N74; EM; 2.65 A; LW=1-554. DR PDB; 9N75; EM; 3.01 A; LW=1-554. DR AlphaFoldDB; P40055; -. DR EMDB; EMD-0441; -. DR EMDB; EMD-0949; -. DR EMDB; EMD-0950; -. DR EMDB; EMD-0951; -. DR EMDB; EMD-0952; -. DR EMDB; EMD-0953; -. DR EMDB; EMD-0954; -. DR EMDB; EMD-0955; -. DR EMDB; EMD-11357; -. DR EMDB; EMD-11358; -. DR EMDB; EMD-11359; -. DR EMDB; EMD-11360; -. DR EMDB; EMD-11807; -. DR EMDB; EMD-11808; -. DR EMDB; EMD-25441; -. DR EMDB; EMD-30574; -. DR EMDB; EMD-30584; -. DR EMDB; EMD-30585; -. DR EMDB; EMD-30588; -. DR EMDB; EMD-49075; -. DR EMDB; EMD-49076; -. DR EMDB; EMD-49077; -. DR EMDB; EMD-49078; -. DR EMDB; EMD-49079; -. DR EMDB; EMD-49080; -. DR EMDB; EMD-49082; -. DR EMDB; EMD-49083; -. DR EMDB; EMD-49084; -. DR EMDB; EMD-49085; -. DR EMDB; EMD-50991; -. DR EMDB; EMD-8859; -. DR EMDB; EMD-9964; -. DR SMR; P40055; -. DR BioGRID; 36827; 354. DR ComplexPortal; CPX-1604; Small ribosomal subunit processome. DR DIP; DIP-5398N; -. DR FunCoup; P40055; 1324. DR IntAct; P40055; 124. DR STRING; 4932.YER082C; -. DR GlyGen; P40055; 2 sites. DR iPTMnet; P40055; -. DR PaxDb; 4932-YER082C; -. DR PeptideAtlas; P40055; -. DR EnsemblFungi; YER082C_mRNA; YER082C; YER082C. DR GeneID; 856815; -. DR KEGG; sce:YER082C; -. DR AGR; SGD:S000000884; -. DR SGD; S000000884; UTP7. DR VEuPathDB; FungiDB:YER082C; -. DR eggNOG; KOG1272; Eukaryota. DR HOGENOM; CLU_022996_1_1_1; -. DR InParanoid; P40055; -. DR OMA; AAFDWHA; -. DR OrthoDB; 10251154at2759; -. DR BioCyc; YEAST:G3O-30252-MONOMER; -. DR Reactome; R-SCE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol. DR BioGRID-ORCS; 856815; 10 hits in 10 CRISPR screens. DR CD-CODE; BDAE0F88; Nucleolus. DR PRO; PR:P40055; -. DR Proteomes; UP000002311; Chromosome V. DR RNAct; P40055; protein. DR GO; GO:0030686; C:90S preribosome; HDA:SGD. DR GO; GO:0005730; C:nucleolus; IDA:SGD. DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome. DR GO; GO:0030688; C:preribosome, small subunit precursor; IDA:GO_Central. DR GO; GO:0032040; C:small-subunit processome; IDA:SGD. DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. DR GO; GO:0030490; P:maturation of SSU-rRNA; NAS:ComplexPortal. DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. DR FunFam; 2.130.10.10:FF:000378; U3 small nucleolar RNA-associated protein 7; 1. DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2. DR InterPro; IPR012952; BING4_C_dom. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR019775; WD40_repeat_CS. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR InterPro; IPR001680; WD40_rpt. DR InterPro; IPR040315; WDR46/Utp7. DR PANTHER; PTHR14085:SF3; WD REPEAT-CONTAINING PROTEIN 46; 1. DR PANTHER; PTHR14085; WD-REPEAT PROTEIN BING4; 1. DR Pfam; PF08149; BING4CT; 1. DR Pfam; PF00400; WD40; 1. DR SMART; SM01033; BING4CT; 1. DR SMART; SM00320; WD40; 3. DR SUPFAM; SSF50978; WD40 repeat-like; 1. DR PROSITE; PS00678; WD_REPEATS_1; 1. DR PROSITE; PS50082; WD_REPEATS_2; 1. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. PE 1: Evidence at protein level; KW 3D-structure; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; KW Ribosome biogenesis; rRNA processing; WD repeat. FT CHAIN 1..554 FT /note="U3 small nucleolar RNA-associated protein 7" FT /id="PRO_0000051319" FT REPEAT 108..149 FT /note="WD 1" FT REPEAT 230..269 FT /note="WD 2" FT REPEAT 272..311 FT /note="WD 3" FT REPEAT 314..351 FT /note="WD 4" FT REGION 1..39 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 475..496 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..12 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 13..23 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 24..35 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT HELIX 16..21 FT /evidence="ECO:0007829|PDB:9G33" FT HELIX 44..62 FT /evidence="ECO:0007829|PDB:9N74" FT HELIX 63..66 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 73..75 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 77..80 FT /evidence="ECO:0007829|PDB:9N74" FT HELIX 83..85 FT /evidence="ECO:0007829|PDB:9N74" FT HELIX 88..94 FT /evidence="ECO:0007829|PDB:9N74" FT HELIX 97..102 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 105..107 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 113..118 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 120..123 FT /evidence="ECO:0007829|PDB:9G33" FT STRAND 125..129 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 132..138 FT /evidence="ECO:0007829|PDB:9N74" FT TURN 139..142 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 143..149 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 156..159 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 161..164 FT /evidence="ECO:0007829|PDB:9G33" FT STRAND 166..169 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 171..177 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 179..181 FT /evidence="ECO:0007829|PDB:9N6W" FT STRAND 183..189 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 192..199 FT /evidence="ECO:0007829|PDB:9N74" FT TURN 200..203 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 204..209 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 213..218 FT /evidence="ECO:0007829|PDB:9N74" FT TURN 219..222 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 223..229 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 232..234 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 237..240 FT /evidence="ECO:0007829|PDB:9N74" FT TURN 242..244 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 247..250 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 254..259 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 261..265 FT /evidence="ECO:0007829|PDB:6KE6" FT STRAND 267..271 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 277..282 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 288..293 FT /evidence="ECO:0007829|PDB:9N74" FT TURN 294..296 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 297..302 FT /evidence="ECO:0007829|PDB:9N74" FT TURN 303..306 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 307..312 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 321..324 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 330..334 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 337..343 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 345..349 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 358..360 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 362..365 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 368..372 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 378..383 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 387..402 FT /evidence="ECO:0007829|PDB:9N74" FT TURN 413..415 FT /evidence="ECO:0007829|PDB:9N74" FT HELIX 422..434 FT /evidence="ECO:0007829|PDB:9N74" FT HELIX 439..441 FT /evidence="ECO:0007829|PDB:9N74" FT HELIX 446..448 FT /evidence="ECO:0007829|PDB:9G33" FT STRAND 449..452 FT /evidence="ECO:0007829|PDB:9N74" FT STRAND 454..456 FT /evidence="ECO:0007829|PDB:9N6W" FT HELIX 463..479 FT /evidence="ECO:0007829|PDB:9G33" FT STRAND 488..490 FT /evidence="ECO:0007829|PDB:9G33" FT STRAND 492..494 FT /evidence="ECO:0007829|PDB:9G33" FT HELIX 497..531 FT /evidence="ECO:0007829|PDB:9N74" FT HELIX 545..549 FT /evidence="ECO:0007829|PDB:9N74" FT HELIX 550..552 FT /evidence="ECO:0007829|PDB:9N74" SQ SEQUENCE 554 AA; 62317 MW; A254AD9AC1142AA5 CRC64; MGHKKNGHRR QIKERENQNK FERSTYTNNA KNNHTQTKDK KLRAGLKKID EQYKKAVSSA AATDYLLPES NGYLEPENEL EKTFKVQQSE IKSSVDVSTA NKALDLSLKE FGPYHIKYAK NGTHLLITGR KGHVASMDWR KGQLRAELFL NETCHSATYL QNEQYFAVAQ KKYTFIYDHE GTELHRLKQH IEARHLDFLP YHYLLVTAGE TGWLKYHDVS TGQLVSELRT KAGPTMAMAQ NPWNAVMHLG HSNGTVSLWS PSMPEPLVKL LSARGPVNSI AIDRSGYYMA TTGADRSMKI WDIRNFKQLH SVESLPTPGT NVSISDTGLL ALSRGPHVTL WKDALKLSGD SKPCFGSMGG NPHRNTPYMS HLFAGNKVEN LGFVPFEDLL GVGHQTGITN LIVPGAGEAN YDALELNPFE TKKQRQEQEV RTLLNKLPAD TITLDPNSIG SVDKRSSTIR LNAKDLAQTT MDANNKAKTN SDIPDVKPDV KGKNSGLRSF LRKKTQNVID ERKLRVQKQL DKEKNIRKRN HQIKQGLISE DHKDVIEEAL SRFG //