ID   BGLJ_ECOLI              Reviewed;         225 AA.
AC   P39404; Q2M5V0;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 3.
DT   04-NOV-2026, entry version 173.
DE   RecName: Full=Transcriptional activator protein BglJ;
GN   Name=bglJ; Synonyms=yjjR; OrderedLocusNames=b4366, JW5955;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ROLE IN BGL OPERON EXPRESSION.
RC   STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX   PubMed=8725214; DOI=10.1093/genetics/143.2.627;
RA   Giel M., Desnoyer M., Lopilato J.;
RT   "A mutation in a new gene, bglJ, activates the bgl operon in Escherichia
RT   coli K-12.";
RL   Genetics 143:627-635(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA   Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT   from 92.8 through 100 minutes.";
RL   Nucleic Acids Res. 23:2105-2119(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   OPERON STRUCTURE, AND INDUCTION.
RC   STRAIN=CSH50;
RX   PubMed=18055596; DOI=10.1128/jb.01447-07;
RA   Stratmann T., Madhusudan S., Schnetz K.;
RT   "Regulation of the yjjQ-bglJ operon, encoding LuxR-type transcription
RT   factors, and the divergent yjjP gene by H-NS and LeuO.";
RL   J. Bacteriol. 190:926-935(2008).
RN   [6]
RP   OPERON STRUCTURE, AND INDUCTION.
RC   STRAIN=K12 / BW25113;
RX   PubMed=19429622; DOI=10.1128/jb.00108-09;
RA   Shimada T., Yamamoto K., Ishihama A.;
RT   "Involvement of the leucine response transcription factor LeuO in
RT   regulation of the genes for sulfa drug efflux.";
RL   J. Bacteriol. 191:4562-4571(2009).
RN   [7]
RP   PROTEIN START SITE, AND INTERACTION WITH RCSB.
RC   STRAIN=CSH50;
RX   PubMed=20952573; DOI=10.1128/jb.00807-10;
RA   Venkatesh G.R., Kembou Koungni F.C., Paukner A., Stratmann T.,
RA   Blissenbach B., Schnetz K.;
RT   "BglJ-RcsB heterodimers relieve repression of the Escherichia coli bgl
RT   operon by H-NS.";
RL   J. Bacteriol. 192:6456-6464(2010).
CC   -!- FUNCTION: A crytic transcriptional activator. When its expression is
CC       induced it relieves H-NS repression of the bgl operon. Acts
CC       independently of transcription factor LeuO.
CC       {ECO:0000269|PubMed:8725214}.
CC   -!- SUBUNIT: Forms a complex with RcsB; genetically both BglJ and RcsB are
CC       required to relieve bgl operon repression by H-NS and by StpA.
CC   -!- INTERACTION:
CC       P39404; P0DMC7: rcsB; NbExp=4; IntAct=EBI-551429, EBI-369670;
CC   -!- INDUCTION: Repressed by H-NS, activated by LeuO. Member of the yjjQ-
CC       bglJ operon. {ECO:0000269|PubMed:18055596,
CC       ECO:0000269|PubMed:19429622}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE78356.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U35834; AAB49332.1; -; Genomic_DNA.
DR   EMBL; U14003; AAA97265.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77322.4; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78356.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_418786.4; NC_000913.3.
DR   RefSeq; WP_001301727.1; NZ_CP009789.1.
DR   AlphaFoldDB; P39404; -.
DR   SMR; P39404; -.
DR   BioGRID; 4262783; 188.
DR   ComplexPortal; CPX-5763; bglJ-rcsB DNA-binding transcription factor complex.
DR   DIP; DIP-9217N; -.
DR   FunCoup; P39404; 17.
DR   IntAct; P39404; 2.
DR   STRING; 511145.b4366; -.
DR   PaxDb; 511145-b4366; -.
DR   EnsemblBacteria; AAC77322; AAC77322; b4366.
DR   GeneID; 948889; -.
DR   KEGG; ecj:JW5955; -.
DR   KEGG; eco:b4366; -.
DR   KEGG; ecoc:C3026_23585; -.
DR   PATRIC; fig|1411691.4.peg.2320; -.
DR   EchoBASE; EB2479; -.
DR   eggNOG; COG2197; Bacteria.
DR   HOGENOM; CLU_000445_90_6_6; -.
DR   InParanoid; P39404; -.
DR   OMA; ADILLYM; -.
DR   OrthoDB; 6623825at2; -.
DR   PhylomeDB; P39404; -.
DR   BioCyc; EcoCyc:G7948-MONOMER; -.
DR   PRO; PR:P39404; -.
DR   Proteomes; UP000000625; Chromosome.
DR   AbasyAtlas; P39404; -.
DR   GO; GO:0005667; C:transcription regulator complex; IPI:ComplexPortal.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IDA:ComplexPortal.
DR   GO; GO:0043470; P:regulation of carbohydrate catabolic process; IDA:ComplexPortal.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   GO; GO:0009314; P:response to radiation; IMP:EcoCyc.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   FunFam; 1.10.10.10:FF:000540; DNA-binding transcriptional activator BglJ; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR-like_C.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   NCBIfam; NF008548; bglJ; 1.
DR   PANTHER; PTHR43214:SF31; TRANSCRIPTIONAL ACTIVATOR PROTEIN BGLJ; 1.
DR   PANTHER; PTHR43214; TWO-COMPONENT RESPONSE REGULATOR; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..225
FT                   /note="Transcriptional activator protein BglJ"
FT                   /id="PRO_0000184140"
FT   DOMAIN          146..211
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        170..189
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   225 AA;  25622 MW;  5EED6E444409A010 CRC64;
     MEHSRIKKRN VALIEKCVMS SIGIESLFRK FAGNPYKLHT YTSQESFQDA MSRISFAAVI
     FSFSAMRSER REGLSCLTEL AIKFPRTRRL VIADDDIEAR LIGSLSPSPL DGVLSKASTL
     EIFHQELFLS LNGVRQATDR LNNQWYINQS RTLSPTEREI LRFMSRGYSM TQIAEQLKRN
     IKTIRAHKFN VMSKLGVSSD AGLLEAADIL LCMRHCETSN VLHPY
//