ID   TLPC_BACSU              Reviewed;         573 AA.
AC   P39209;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 3.
DT   02-SEP-2026, entry version 149.
DE   RecName: Full=Methyl-accepting chemotaxis protein TlpC;
GN   Name=tlpC; OrderedLocusNames=BSU03440;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Bacillati; Bacillota; Bacilli; Caryophanales; Bacillaceae;
OC   Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / OI1085;
RX   PubMed=7921238; DOI=10.1099/13500872-140-8-1847;
RA   Hanlon D.W., Rosario M.M.L., Ordal G.W., Venema G., van Sinderen D.;
RT   "Identification of TlpC, a novel 62 kDa MCP-like protein from Bacillus
RT   subtilis.";
RL   Microbiology 140:1847-1854(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=7704255; DOI=10.1099/13500872-141-2-277;
RA   Fujishima Y., Yamane K.;
RT   "A 10 kb nucleotide sequence at the 5' flanking region (32 degrees) of
RT   srfAA of the Bacillus subtilis chromosome.";
RL   Microbiology 141:277-279(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969502; DOI=10.1099/13500872-142-11-3047;
RA   Yamane K., Kumano M., Kurita K.;
RT   "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome:
RT   determination of the sequence of a 146 kb segment and identification of 113
RT   genes.";
RL   Microbiology 142:3047-3056(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [5]
RP   SEQUENCE REVISION TO 216 AND 332.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; Z34005; CAA83970.1; -; Genomic_DNA.
DR   EMBL; D30762; BAA06432.1; -; Genomic_DNA.
DR   EMBL; D50453; BAA08978.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12138.2; -; Genomic_DNA.
DR   PIR; I40496; I40496.
DR   RefSeq; NP_388226.2; NC_000964.3.
DR   RefSeq; WP_003246498.1; NC_000964.3.
DR   AlphaFoldDB; P39209; -.
DR   SMR; P39209; -.
DR   FunCoup; P39209; 136.
DR   IntAct; P39209; 2.
DR   STRING; 224308.BSU03440; -.
DR   jPOST; P39209; -.
DR   PaxDb; 224308-BSU03440; -.
DR   EnsemblBacteria; CAB12138; CAB12138; BSU_03440.
DR   GeneID; 938316; -.
DR   KEGG; bsu:BSU03440; -.
DR   PATRIC; fig|224308.179.peg.361; -.
DR   eggNOG; COG0840; Bacteria.
DR   eggNOG; COG3290; Bacteria.
DR   InParanoid; P39209; -.
DR   OrthoDB; 9814363at2; -.
DR   PhylomeDB; P39209; -.
DR   BioCyc; BSUB:BSU03440-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   AbasyAtlas; P39209; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd11386; MCP_signal; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR033463; sCache_3.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   PANTHER; PTHR32089:SF114; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   Pfam; PF17202; sCache_3_3; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   SUPFAM; SSF103190; Sensory domain-like; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chemotaxis; Membrane; Methylation; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..573
FT                   /note="Methyl-accepting chemotaxis protein TlpC"
FT                   /id="PRO_0000110561"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..188
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        208..573
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          209..261
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          280..544
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   MOD_RES         276
FT                   /note="Glutamate methyl ester (Gln)"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         535
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         542
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        216
FT                   /note="N -> T (in Ref. 2; BAA06432 and 3; BAA08978)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        332
FT                   /note="A -> P (in Ref. 2; BAA06432 and 3; BAA08978)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   573 AA;  61784 MW;  80E3A90EE35E5CDF CRC64;
     MLIKRFKMKL GTKILCLVFV VILLFSASVG TVMLKEITES MKQMATEKAK GDLALSSTYI
     DDVMSGDWQV KNNKLYKGQT QINGNEDIVD LLGEKTGDTI TIFQGDTRVA TNVMKNGERA
     VGTQASSEVI AAVLKKGKRF YGQADVAGSS YQTAYMPLKD QNGNIIGMLY TGANQSILAS
     LTQSLFTQFA IVLVIVIMVS VILVLVFTRK INKRLNALKS AFESAGNGDM TIEVSDKTGD
     ELSELSVYYN KMRMKLNDTI QTVQQSALQL ASASQQLSAG AEETNQASEK ITEAVQQIAN
     GAQDQITRIE NSESSLKQAS ADIRDISANT AAIADKGQLA QSKADIGQKE IANVQAQMDA
     IHQSIQKSGE IIHQLDGRSK QIEQILSVIT QIADQTNLLA LNAAIEAARA GEQGKGFAVV
     ADEVRKLAEE SQQSAGQISK LIIEIQKDMN RSARSVEHVK TEAAEGVTMI QRTRDAFKEI
     AAATGEISAE ISDLSASVTN ISASAHQIND SFAANTADIK ESTKNTRQAA ALTEEQFAAM
     EEITAASETL SQLAEELTGI ISQFKMINQA ENG
//