ID   COX14_YEAST             Reviewed;          70 AA.
AC   P39103; D6W0F6;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   02-SEP-2026, entry version 151.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX14;
GN   Name=COX14; OrderedLocusNames=YML129C; ORFNames=YM4987.06C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 24657 / D273-10B;
RX   PubMed=7797555; DOI=10.1074/jbc.270.26.15585;
RA   Glerum D.M., Koerner T.J., Tzagoloff A.;
RT   "Cloning and characterization of COX14, whose product is required for
RT   assembly of yeast cytochrome oxidase.";
RL   J. Biol. Chem. 270:15585-15590(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872; DOI=10.1038/387s090;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Required for the synthesis of yeast cytochrome oxidase.
CC   -!- INTERACTION:
CC       P39103; P40452: COA1; NbExp=2; IntAct=EBI-5113, EBI-25287;
CC       P39103; P32335: MSS51; NbExp=3; IntAct=EBI-5113, EBI-11318;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane
CC       protein.
CC   -!- MISCELLANEOUS: Present with 6840 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U15040; AAA50449.1; -; Genomic_DNA.
DR   EMBL; Z50178; CAA90554.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA09770.1; -; Genomic_DNA.
DR   PIR; A57515; A57515.
DR   RefSeq; NP_013577.1; NM_001182492.1.
DR   AlphaFoldDB; P39103; -.
DR   BioGRID; 35076; 80.
DR   ComplexPortal; CPX-1423; COX1 pre-assembly complex.
DR   DIP; DIP-4151N; -.
DR   FunCoup; P39103; 66.
DR   IntAct; P39103; 13.
DR   MINT; P39103; -.
DR   STRING; 4932.YML129C; -.
DR   iPTMnet; P39103; -.
DR   PaxDb; 4932-YML129C; -.
DR   PeptideAtlas; P39103; -.
DR   EnsemblFungi; YML129C_mRNA; YML129C; YML129C.
DR   GeneID; 854910; -.
DR   KEGG; sce:YML129C; -.
DR   AGR; SGD:S000004598; -.
DR   SGD; S000004598; COX14.
DR   VEuPathDB; FungiDB:YML129C; -.
DR   eggNOG; ENOG502S780; Eukaryota.
DR   HOGENOM; CLU_187072_0_0_1; -.
DR   InParanoid; P39103; -.
DR   OMA; YAWYTRV; -.
DR   OrthoDB; 4083952at2759; -.
DR   BioCyc; YEAST:G3O-32707-MONOMER; -.
DR   BioGRID-ORCS; 854910; 6 hits in 10 CRISPR screens.
DR   PRO; PR:P39103; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; P39103; protein.
DR   GO; GO:0005740; C:mitochondrial envelope; IDA:SGD.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR   GO; GO:0005759; C:mitochondrial matrix; IDA:SGD.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0033617; P:mitochondrial respiratory chain complex IV assembly; IMP:SGD.
DR   GO; GO:0070130; P:negative regulation of mitochondrial translation; IPI:SGD.
DR   GO; GO:0050821; P:protein stabilization; NAS:ComplexPortal.
DR   InterPro; IPR029208; COX14.
DR   Pfam; PF14880; COX14; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..70
FT                   /note="Cytochrome c oxidase assembly protein COX14"
FT                   /id="PRO_0000183930"
FT   TRANSMEM        17..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          49..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   70 AA;  7959 MW;  B26DEAE366707617 CRC64;
     MSKYAWYTRV TDTLHRLTVL TLVGGTLYMS GGLAYTLYMN GKKYEQQVTQ QKALEEDNQQ
     LQSPTAPPTE
//