ID   RAN_VICFA               Reviewed;         221 AA.
AC   P38548;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   02-SEP-2026, entry version 112.
DE   RecName: Full=GTP-binding nuclear protein Ran/TC4;
OS   Vicia faba (Broad bean) (Faba vulgaris).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Fabeae; Vicia.
OX   NCBI_TaxID=3906;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cotyledon;
RX   PubMed=8204834; DOI=10.1007/bf00014451;
RA   Saalbach G., Christov V.;
RT   "Sequence of a plant cDNA from Vicia faba encoding a novel Ran-related GTP-
RT   binding protein.";
RL   Plant Mol. Biol. 24:969-972(1994).
CC   -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC       Required for the import of protein into the nucleus and also for RNA
CC       export. Involved in chromatin condensation and control of cell cycle
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Found in a nuclear export complex with RanGTP, exportin and
CC       pre-miRNA (By similarity). {ECO:0000250|UniProtKB:P62825}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00752, ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z24678; CAA80845.1; -; mRNA.
DR   PIR; S46498; S46498.
DR   AlphaFoldDB; P38548; -.
DR   SMR; P38548; -.
DR   EnsemblPlants; Vfaba.Hedin2.R1.2g186280.1; cds:Vfaba.Hedin2.R1.2g186280.1; Vfaba.Hedin2.R1.2g186280.
DR   Gramene; Vfaba.Hedin2.R1.2g186280.1; cds:Vfaba.Hedin2.R1.2g186280.1; Vfaba.Hedin2.R1.2g186280.
DR   OrthoDB; 2012850at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:TreeGrafter.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IEA:TreeGrafter.
DR   CDD; cd00877; Ran; 1.
DR   FunFam; 3.40.50.300:FF:000369; GTP-binding nuclear protein; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002041; Ran_GTPase.
DR   InterPro; IPR005225; Small_GTP-bd.
DR   InterPro; IPR001806; Small_GTPase.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR24071:SF39; GTP-BINDING NUCLEAR PROTEIN RAN-3; 1.
DR   PANTHER; PTHR24071; RAN GTPASE; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00627; GTPRANTC4.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00176; RAN; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51418; RAN; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Protein transport; Transport.
FT   CHAIN           1..221
FT                   /note="GTP-binding nuclear protein Ran/TC4"
FT                   /id="PRO_0000208727"
FT   DOMAIN          10..174
FT                   /note="Small GTPase Ran-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00752"
FT   REGION          40..48
FT                   /note="Switch-I"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00752"
FT   REGION          71..87
FT                   /note="Switch-II"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00752"
FT   BINDING         21..28
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         71
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         125..128
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         153..155
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
SQ   SEQUENCE   221 AA;  25290 MW;  40C2C711F1C2DE63 CRC64;
     MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV HPLDFFTNCG
     KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT YKNVPTWHRD LCRVCENIPI
     VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY EISAKSNYNF EKPFLYLARK LAGDANLHFV
     ESPALAPPEV QIDIALQQRH ENEILEAANQ PLPDDDDDAF E
//