ID   RAN_PLAFA               Reviewed;         214 AA.
AC   P38545;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   02-SEP-2026, entry version 124.
DE   RecName: Full=GTP-binding nuclear protein Ran;
DE   AltName: Full=GTPase Ran;
DE   AltName: Full=Ras-like protein TC4;
OS   Plasmodium falciparum.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Laverania.
OX   NCBI_TaxID=5833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=DD2;
RX   PubMed=8198605; DOI=10.1006/bbrc.1994.1718;
RA   Dontfraid F.F., Chakrabarti D.;
RT   "Cloning and expression of a cDNA encoding the homologue of Ran/TC4 GTP-
RT   binding protein from Plasmodium falciparum.";
RL   Biochem. Biophys. Res. Commun. 201:423-429(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IT04;
RX   PubMed=7969273; DOI=10.1016/0166-6851(94)90083-3;
RA   Sultan A., Richardson W., Alano P., Arnot D., Doerig C.;
RT   "Cloning and characterisation of a Plasmodium falciparum homologue of the
RT   Ran/TC4 signal transducing GTPase involved in cell cycle control.";
RL   Mol. Biochem. Parasitol. 65:331-338(1994).
CC   -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC       Required for the import of protein into the nucleus and also for RNA
CC       export. Involved in chromatin condensation and control of cell cycle
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Found in a nuclear export complex with RanGTP, exportin and
CC       pre-miRNA (By similarity). {ECO:0000250|UniProtKB:P62825}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00752, ECO:0000305}.
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DR   EMBL; U06051; AAA19587.1; -; mRNA.
DR   EMBL; X73954; CAA52140.1; -; Genomic_DNA.
DR   PIR; JC2374; JC2374.
DR   PIR; S40121; S40121.
DR   AlphaFoldDB; P38545; -.
DR   SMR; P38545; -.
DR   DrugBank; DB11638; Artenimol.
DR   EnsemblProtists; PF3D7_1117700.1; PF3D7_1117700.1-p1; PF3D7_1117700.
DR   VEuPathDB; PlasmoDB:PF3D7_1117700; -.
DR   VEuPathDB; PlasmoDB:Pf7G8-2_000340500; -.
DR   VEuPathDB; PlasmoDB:Pf7G8_110021300; -.
DR   VEuPathDB; PlasmoDB:PfCD01_110023100; -.
DR   VEuPathDB; PlasmoDB:PfDd2_110020700; -.
DR   VEuPathDB; PlasmoDB:PfGA01_110021900; -.
DR   VEuPathDB; PlasmoDB:PfGB4_110024200; -.
DR   VEuPathDB; PlasmoDB:PfGN01_110022200; -.
DR   VEuPathDB; PlasmoDB:PfHB3_110020800; -.
DR   VEuPathDB; PlasmoDB:PfIT_110022000; -.
DR   VEuPathDB; PlasmoDB:PfKE01_110022200; -.
DR   VEuPathDB; PlasmoDB:PfKH01_110021800; -.
DR   VEuPathDB; PlasmoDB:PfKH02_110022700; -.
DR   VEuPathDB; PlasmoDB:PfML01_110022500; -.
DR   VEuPathDB; PlasmoDB:PfNF135_110020900; -.
DR   VEuPathDB; PlasmoDB:PfNF166_110021100; -.
DR   VEuPathDB; PlasmoDB:PfNF54_110022000; -.
DR   VEuPathDB; PlasmoDB:PfSD01_110020300; -.
DR   VEuPathDB; PlasmoDB:PfSN01_110020800; -.
DR   VEuPathDB; PlasmoDB:PfTG01_110022100; -.
DR   OMA; FNAWDTA; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:TreeGrafter.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IEA:TreeGrafter.
DR   CDD; cd00877; Ran; 1.
DR   FunFam; 3.40.50.300:FF:001228; GTP-binding nuclear protein; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002041; Ran_GTPase.
DR   InterPro; IPR005225; Small_GTP-bd.
DR   InterPro; IPR001806; Small_GTPase.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR24071:SF0; GTP-BINDING NUCLEAR PROTEIN RAN; 1.
DR   PANTHER; PTHR24071; RAN GTPASE; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00627; GTPRANTC4.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00176; RAN; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51418; RAN; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Protein transport; Transport.
FT   CHAIN           1..214
FT                   /note="GTP-binding nuclear protein Ran"
FT                   /id="PRO_0000208714"
FT   DOMAIN          6..170
FT                   /note="Small GTPase Ran-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00752"
FT   REGION          36..44
FT                   /note="Switch-I"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00752"
FT   REGION          67..83
FT                   /note="Switch-II"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00752"
FT   BINDING         17..24
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         67
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         121..124
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         149..151
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   VARIANT         40
FT                   /note="P -> A (in strain: IT04)"
FT   VARIANT         196
FT                   /note="E -> G (in strain: IT04)"
SQ   SEQUENCE   214 AA;  24875 MW;  5CBF7739EF5D26C2 CRC64;
     MDSQEYIPQY KLILVGDGGV GKTTFVKRHL TGEFEKKYIP TLGVEVHPLK FQTNFGKTQF
     NVWDTAGQEK FGGLRDGYYI KSDCAIIMFD VSSRITYKNV PNWYRDITRV CETIPMVLVG
     NKVDVKDRQV KSRQIQFHRK RNLQYYDLSA RSNYNFEKPF LWLARRLSNQ PNLVFVGEHA
     KAPEFQIDLN IVREAEKELE QAAAVAIDEE DIEN
//