ID   MOH1_YEAST              Reviewed;         138 AA.
AC   P38191; D6VPV0;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   02-SEP-2026, entry version 149.
DE   RecName: Full=Pro-Apoptotic protein MOH1 {ECO:0000303|PubMed:28173693};
DE   AltName: Full=Protein yippee-like MOH1 {ECO:0000303|PubMed:28173693};
GN   Name=MOH1 {ECO:0000303|PubMed:28173693}; OrderedLocusNames=YBL049W;
GN   ORFNames=YBL0518;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8154187; DOI=10.1002/yea.320091210;
RA   Scherens B., el Bakkoury M., Vierendeels F., Dubois E., Messenguy F.;
RT   "Sequencing and functional analysis of a 32,560 bp segment on the left arm
RT   of yeast chromosome II. Identification of 26 open reading frames, including
RT   the KIP1 and SEC17 genes.";
RL   Yeast 9:1355-1371(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA   Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA   Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA   Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA   Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA   Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA   Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA   Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA   Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA   Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA   Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA   Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA   Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA   Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA   Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA   Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA   Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA   Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA   Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA   Mewes H.-W., Kleine K.;
RT   "Complete DNA sequence of yeast chromosome II.";
RL   EMBO J. 13:5795-5809(1994).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=28173693; DOI=10.4014/jmb.1610.10045;
RA   Lee J.Y., Jun D.Y., Park J.E., Kwon G.H., Kim J.S., Kim Y.H.;
RT   "Pro-Apoptotic Role of the Human YPEL5 Gene Identified by Functional
RT   Complementation of a Yeast moh1Delta Mutation.";
RL   J. Microbiol. Biotechnol. 27:633-643(2017).
CC   -!- FUNCTION: Pro-Apoptotic protein involved in mitochondria-dependent
CC       apoptosis induced by DNA damage. {ECO:0000269|PubMed:28173693}.
CC   -!- DISRUPTION PHENOTYPE: Exhibits enhanced cell viability when treated
CC       with lethal UV irradiation, methyl methanesulfonate (MMS), camptothecin
CC       (CPT), heat shock at 50 degrees Celsius, or KCl.
CC       {ECO:0000269|PubMed:28173693}.
CC   -!- SIMILARITY: Belongs to the yippee family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z23261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z35810; CAA84869.1; -; Genomic_DNA.
DR   EMBL; AY692611; AAT92630.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAA07070.1; -; Genomic_DNA.
DR   PIR; S45784; S45784.
DR   RefSeq; NP_009504.1; NM_001178289.1.
DR   AlphaFoldDB; P38191; -.
DR   SMR; P38191; -.
DR   BioGRID; 32649; 47.
DR   DIP; DIP-2081N; -.
DR   FunCoup; P38191; 492.
DR   IntAct; P38191; 21.
DR   STRING; 4932.YBL049W; -.
DR   iPTMnet; P38191; -.
DR   PaxDb; 4932-YBL049W; -.
DR   PeptideAtlas; P38191; -.
DR   EnsemblFungi; YBL049W_mRNA; YBL049W; YBL049W.
DR   GeneID; 852231; -.
DR   KEGG; sce:YBL049W; -.
DR   AGR; SGD:S000000145; -.
DR   SGD; S000000145; MOH1.
DR   VEuPathDB; FungiDB:YBL049W; -.
DR   eggNOG; KOG3399; Eukaryota.
DR   HOGENOM; CLU_043857_4_1_1; -.
DR   InParanoid; P38191; -.
DR   OMA; HLAFKGH; -.
DR   OrthoDB; 6407410at2759; -.
DR   BioCyc; YEAST:G3O-28948-MONOMER; -.
DR   Reactome; R-SCE-6798695; Neutrophil degranulation.
DR   BioGRID-ORCS; 852231; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P38191; -.
DR   Proteomes; UP000002311; Chromosome II.
DR   RNAct; P38191; protein.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR   InterPro; IPR034751; Yippee.
DR   InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR   InterPro; IPR039058; Yippee_fam.
DR   PANTHER; PTHR13848; PROTEIN YIPPEE-LIKE CG15309-RELATED; 1.
DR   Pfam; PF03226; Yippee-Mis18; 1.
DR   PROSITE; PS51792; YIPPEE; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..138
FT                   /note="Pro-Apoptotic protein MOH1"
FT                   /id="PRO_0000212410"
FT   DOMAIN          41..138
FT                   /note="Yippee"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         48
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         101
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT   BINDING         104
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
SQ   SEQUENCE   138 AA;  16085 MW;  C76DE1D470042D90 CRC64;
     MGLRYSIYIE NPLSSPSSSY KSINDPLFHS QHRSQKNVSF ITYGCRHCKT HLSSSFQIIS
     RDYRGRTGTA YLMNKVVNVV EGKVEQRRML TGDYLVCDIL CHWCKRNVGW KYLQSSNDDQ
     QYKEGKFILE LKNICKCT
//