ID   FBPC_ECOLI              Reviewed;         348 AA.
AC   P37009; P77157;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 3.
DT   02-SEP-2026, entry version 195.
DE   RecName: Full=Fe(3+) ions import ATP-binding protein FbpC {ECO:0000255|HAMAP-Rule:MF_01706};
DE            EC=7.2.2.7 {ECO:0000255|HAMAP-Rule:MF_01706};
GN   Name=fbpC {ECO:0000255|HAMAP-Rule:MF_01706}; Synonyms=afuC, yagC;
GN   OrderedLocusNames=b0262, JW0254;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA   Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T.,
RA   Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S.,
RA   Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.;
RT   "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0
RT   - 6.0 min (189,987 - 281,416bp) region.";
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO
RP   147-148.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-220.
RX   PubMed=8113168; DOI=10.1128/jb.176.5.1297-1302.1994;
RA   Volkert M.R., Loewen P.C., Switala J., Crowley D., Conley M.;
RT   "The delta (argF-lacZ)205(U169) deletion greatly enhances resistance to
RT   hydrogen peroxide in stationary-phase Escherichia coli.";
RL   J. Bacteriol. 176:1297-1302(1994).
CC   -!- FUNCTION: Part of the ABC transporter complex FbpABC involved in Fe(3+)
CC       ions import. Responsible for energy coupling to the transport system.
CC       {ECO:0000255|HAMAP-Rule:MF_01706}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Fe(3+)(out) + ATP + H2O = Fe(3+)(in) + ADP + phosphate + H(+);
CC         Xref=Rhea:RHEA:12332, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29034, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:456216; EC=7.2.2.7; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01706};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (FbpC),
CC       two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).
CC       {ECO:0000255|HAMAP-Rule:MF_01706}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01706}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01706}.
CC   -!- MISCELLANEOUS: In E.coli, the afu system seems to have been deleted by
CC       an insertion sequence. AfuA is totally lost, afuB is partially present
CC       and afuC is totally conserved.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Fe(3+) ion
CC       importer (TC 3.A.1.10) family. {ECO:0000255|HAMAP-Rule:MF_01706}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB08683.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=L20943; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U70214; AAB08683.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC73365.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAA77930.2; -; Genomic_DNA.
DR   EMBL; L20943; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   RefSeq; NP_414796.2; NC_000913.3.
DR   RefSeq; WP_000192349.1; NZ_CP009789.1.
DR   AlphaFoldDB; P37009; -.
DR   SMR; P37009; -.
DR   BioGRID; 4262792; 89.
DR   BioGRID; 851989; 2.
DR   DIP; DIP-9064N; -.
DR   FunCoup; P37009; 426.
DR   IntAct; P37009; 7.
DR   STRING; 511145.b0262; -.
DR   PaxDb; 511145-b0262; -.
DR   EnsemblBacteria; AAC73365; AAC73365; b0262.
DR   GeneID; 86977687; -.
DR   GeneID; 947676; -.
DR   KEGG; ecj:JW0254; -.
DR   KEGG; eco:b0262; -.
DR   KEGG; ecoc:C3026_01265; -.
DR   PATRIC; fig|1411691.4.peg.2019; -.
DR   EchoBASE; EB2244; -.
DR   eggNOG; COG3842; Bacteria.
DR   HOGENOM; CLU_000604_1_1_6; -.
DR   InParanoid; P37009; -.
DR   OMA; WEIVANW; -.
DR   OrthoDB; 9802264at2; -.
DR   PhylomeDB; P37009; -.
DR   BioCyc; EcoCyc:YAGC-MONOMER; -.
DR   PRO; PR:P37009; -.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015408; F:ABC-type ferric iron transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015697; P:quaternary ammonium group transport; IEA:UniProtKB-ARBA.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   FunFam; 3.40.50.300:FF:000425; Probable ABC transporter, ATP-binding subunit; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR050093; ABC_SmlMolc_Importer.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013611; Transp-assoc_OB_typ2.
DR   NCBIfam; NF008513; PRK11432.1; 1.
DR   PANTHER; PTHR42781; SPERMIDINE/PUTRESCINE IMPORT ATP-BINDING PROTEIN POTA; 1.
DR   PANTHER; PTHR42781:SF4; SPERMIDINE_PUTRESCINE IMPORT ATP-BINDING PROTEIN POTA; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF08402; TOBE_2; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; MOP-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51242; FBPC; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Iron;
KW   Iron transport; Membrane; Nucleotide-binding; Reference proteome;
KW   Translocase; Transport.
FT   CHAIN           1..348
FT                   /note="Fe(3+) ions import ATP-binding protein FbpC"
FT                   /id="PRO_0000092347"
FT   DOMAIN          7..237
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01706"
SQ   SEQUENCE   348 AA;  39059 MW;  D4AD33754217DA1A CRC64;
     MTQKNFVELR NVTKRFGSNT VIDNINLTIP QGQMVTLLGP SGCGKTTILR LVAGLEKPSE
     GQIFIDGEDV THRSIQQRDI CMVFQSYALF PHMSLGENVG YGLKMLGVPR AELKARVKEA
     LAMVDLEGFE DRFVDQISGG QQQRVALARA LILKPKVLLF DEPLSNLDAN LRRSMRDKIR
     ELQKQFDITS LYVTHDQSEA FAVSDTVLVM NKGHIMQIGS PQDLYRQPAS RFMASFMGDA
     NLFPATFSDG YVDIYGYHLP RPLHFGTQGE GMVGVRPEAI TLSDRGEESQ RCVIRHVAYM
     GPQYEVTVEW HGQEILLQVN ATRLQPDVGE QYYLEIHPYG MFVLADAA
//