ID FGF7_MOUSE Reviewed; 194 AA. AC P36363; DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 1. DT 02-SEP-2026, entry version 186. DE RecName: Full=Fibroblast growth factor 7; DE Short=FGF-7; DE AltName: Full=Heparin-binding growth factor 7; DE Short=HBGF-7; DE AltName: Full=Keratinocyte growth factor; DE Short=KGF; DE Flags: Precursor; GN Name=Fgf7; Synonyms=Fgf-7, Kgf; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=8186145; DOI=10.1016/0925-4773(94)90050-7; RA Mason I.J., Fuller-Pace F., Smith R., Dickson C.; RT "FGF-7 (keratinocyte growth factor) expression during mouse development RT suggests roles in myogenesis, forebrain regionalisation and epithelial- RT mesenchymal interactions."; RL Mech. Dev. 45:15-30(1994). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=FVB/N; RA Jones M.L., Dato M.E., Greenberg J.M.; RL Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C3H/He; TISSUE=Osteoblast; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Plays an important role in the regulation of embryonic CC development, cell proliferation and cell differentiation. Required for CC normal branching morphogenesis. Growth factor active on keratinocytes. CC Possible major paracrine effector of normal epithelial cell CC proliferation (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Interacts with FGFBP1. Interacts with FGFR2. Affinity between CC fibroblast growth factors (FGFs) and their receptors is increased by CC heparan sulfate glycosaminoglycans that function as coreceptors (By CC similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z22703; CAA80403.1; -; mRNA. DR EMBL; U58503; AAB01343.1; -; Genomic_DNA. DR EMBL; BC052847; AAH52847.1; -; mRNA. DR CCDS; CCDS16681.1; -. DR PIR; I48610; I48610. DR RefSeq; NP_032034.1; NM_008008.4. DR AlphaFoldDB; P36363; -. DR SMR; P36363; -. DR BioGRID; 199652; 1. DR FunCoup; P36363; 1230. DR IntAct; P36363; 1. DR STRING; 10090.ENSMUSP00000069681; -. DR GlyCosmos; P36363; 1 site, No reported glycans. DR GlyGen; P36363; 1 site. DR iPTMnet; P36363; -. DR PhosphoSitePlus; P36363; -. DR PaxDb; 10090-ENSMUSP00000069681; -. DR ProteomicsDB; 271754; -. DR Pumba; P36363; -. DR Antibodypedia; 12143; 412 antibodies from 39 providers. DR DNASU; 14178; -. DR Ensembl; ENSMUST00000064794.14; ENSMUSP00000069681.8; ENSMUSG00000027208.15. DR Ensembl; ENSMUST00000110442.2; ENSMUSP00000106072.2; ENSMUSG00000027208.15. DR GeneID; 14178; -. DR KEGG; mmu:14178; -. DR UCSC; uc008mdj.2; mouse. DR AGR; MGI:95521; -. DR CTD; 2252; -. DR MGI; MGI:95521; Fgf7. DR VEuPathDB; HostDB:ENSMUSG00000027208; -. DR eggNOG; KOG3885; Eukaryota. DR GeneTree; ENSGT00940000159843; -. DR HOGENOM; CLU_081609_3_1_1; -. DR InParanoid; P36363; -. DR OMA; QYYICMN; -. DR OrthoDB; 5987799at2759; -. DR PhylomeDB; P36363; -. DR Reactome; R-MMU-109704; PI3K Cascade. DR Reactome; R-MMU-1257604; PIP3 activates AKT signaling. DR Reactome; R-MMU-190377; FGFR2b ligand binding and activation. DR Reactome; R-MMU-5654221; Phospholipase C-mediated cascade, FGFR2. DR Reactome; R-MMU-5654695; PI-3K cascade:FGFR2. DR Reactome; R-MMU-5654699; SHC-mediated cascade:FGFR2. DR Reactome; R-MMU-5654700; FRS-mediated FGFR2 signaling. DR Reactome; R-MMU-5654727; Negative regulation of FGFR2 signaling. DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade. DR Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling. DR BioGRID-ORCS; 14178; 1 hit in 76 CRISPR screens. DR PRO; PR:P36363; -. DR Proteomes; UP000000589; Chromosome 2. DR RNAct; P36363; protein. DR Bgee; ENSMUSG00000027208; Expressed in mesenchyme of tongue and 218 other cell types or tissues. DR ExpressionAtlas; P36363; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005576; C:extracellular region; IDA:MGI. DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO. DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI. DR GO; GO:0098794; C:postsynapse; IDA:SynGO. DR GO; GO:0042056; F:chemoattractant activity; ISO:GO_Central. DR GO; GO:0008083; F:growth factor activity; ISO:GO_Central. DR GO; GO:0008201; F:heparin binding; ISO:GO_Central. DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; ISO:GO_Central. DR GO; GO:0030036; P:actin cytoskeleton organization; ISO:GO_Central. DR GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IDA:MGI. DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISO:MGI. DR GO; GO:0031069; P:hair follicle morphogenesis; IMP:MGI. DR GO; GO:0030324; P:lung development; ISO:GO_Central. DR GO; GO:0010463; P:mesenchymal cell proliferation; ISO:GO_Central. DR GO; GO:0022008; P:neurogenesis; IBA:GO_Central. DR GO; GO:0001541; P:ovarian follicle development; ISO:GO_Central. DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; ISO:GO_Central. DR GO; GO:0008654; P:phospholipid biosynthetic process; ISO:GO_Central. DR GO; GO:0050918; P:positive chemotaxis; ISO:GO_Central. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:MGI. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IDA:CACAO. DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:MGI. DR GO; GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; ISO:MGI. DR GO; GO:0051549; P:positive regulation of keratinocyte migration; ISO:GO_Central. DR GO; GO:0010838; P:positive regulation of keratinocyte proliferation; ISO:GO_Central. DR GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:GO_Central. DR GO; GO:0034394; P:protein localization to cell surface; ISO:GO_Central. DR GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IDA:MGI. DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central. DR GO; GO:0090128; P:regulation of synapse maturation; IDA:SynGO. DR GO; GO:0061033; P:secretion by lung epithelial cell involved in lung growth; ISO:GO_Central. DR GO; GO:0043129; P:surfactant homeostasis; ISO:GO_Central. DR CDD; cd23319; beta-trefoil_FGF7; 1. DR FunFam; 2.80.10.50:FF:000004; Fibroblast growth factor; 1. DR Gene3D; 2.80.10.50; -; 1. DR InterPro; IPR002209; Fibroblast_GF_fam. DR InterPro; IPR008996; IL1/FGF. DR PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00263; HBGFFGF. DR PRINTS; PR00262; IL1HBGF. DR SMART; SM00442; FGF; 1. DR SUPFAM; SSF50353; Cytokine; 1. DR PROSITE; PS00247; HBGF_FGF; 1. PE 2: Evidence at transcript level; KW Glycoprotein; Growth factor; Heparin-binding; Mitogen; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..31 FT /evidence="ECO:0000250" FT CHAIN 32..194 FT /note="Fibroblast growth factor 7" FT /id="PRO_0000008966" FT CARBOHYD 45 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" SQ SEQUENCE 194 AA; 22347 MW; 805C30D4B1D27C73 CRC64; MRKWILTRIL PTLLYRSCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNSYNIMEI RTVAVGIVAI KGVESEYYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHSG GEMFVALNQK GIPVKGKKTK KEQKTAHFLP MAIT //