ID   LY6G_MOUSE              Reviewed;         134 AA.
AC   P35461; A0A087WQF5;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2020, sequence version 2.
DT   10-JUN-2026, entry version 144.
DE   RecName: Full=Lymphocyte antigen 6G;
DE            Short=Ly-6G;
DE   AltName: Full=Ly-6G.1;
DE   Flags: Precursor;
GN   Name=Ly6g;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-134, AND TISSUE SPECIFICITY.
RC   STRAIN=BALB/cJ; TISSUE=Liver;
RX   PubMed=8515066; DOI=10.4049/jimmunol.150.12.5379;
RA   Fleming T.J., O'Huigin C., Malek T.R.;
RT   "Characterization of two novel Ly-6 genes. Protein sequence and potential
RT   structural similarity to alpha-bungarotoxin and other neurotoxins.";
RL   J. Immunol. 150:5379-5390(1993).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-
CC       anchor {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in bone marrow.
CC       {ECO:0000269|PubMed:8515066}.
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DR   EMBL; AC116498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X70920; CAA50269.1; -; Genomic_DNA.
DR   EMBL; X70921; CAA50269.1; JOINED; Genomic_DNA.
DR   CCDS; CCDS79377.1; -.
DR   PIR; I48640; I48640.
DR   RefSeq; NP_001297367.1; NM_001310438.1.
DR   RefSeq; NP_001361159.1; NM_001374230.1.
DR   AlphaFoldDB; P35461; -.
DR   FunCoup; P35461; 181.
DR   STRING; 10090.ENSMUSP00000140173; -.
DR   iPTMnet; P35461; -.
DR   PhosphoSitePlus; P35461; -.
DR   PaxDb; 10090-ENSMUSP00000140173; -.
DR   Ensembl; ENSMUST00000190262.2; ENSMUSP00000140173.2; ENSMUSG00000022582.5.
DR   GeneID; 546644; -.
DR   KEGG; mmu:546644; -.
DR   AGR; MGI:109440; -.
DR   CTD; 546644; -.
DR   MGI; MGI:109440; Ly6g.
DR   VEuPathDB; HostDB:ENSMUSG00000022582; -.
DR   eggNOG; ENOG502TD4F; Eukaryota.
DR   GeneTree; ENSGT00940000154560; -.
DR   HOGENOM; CLU_106772_0_0_1; -.
DR   InParanoid; P35461; -.
DR   OMA; CHIAKSC; -.
DR   OrthoDB; 9624109at2759; -.
DR   PhylomeDB; P35461; -.
DR   BioGRID-ORCS; 546644; 0 hits in 37 CRISPR screens.
DR   PRO; PR:P35461; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; P35461; protein.
DR   Bgee; ENSMUSG00000022582; Expressed in granulocyte and 35 other cell types or tissues.
DR   ExpressionAtlas; P35461; baseline and differential.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0033130; F:acetylcholine receptor binding; IBA:GO_Central.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IBA:GO_Central.
DR   GO; GO:0095500; P:acetylcholine receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd23541; TFP_LU_ECD_Ly6A_like; 1.
DR   FunFam; 2.10.60.10:FF:000003; lymphocyte antigen 6E isoform X1; 1.
DR   Gene3D; 2.10.60.10; CD59; 1.
DR   InterPro; IPR018363; CD59_antigen_CS.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR051445; LY6H/LY6L_nAChR_modulators.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   PANTHER; PTHR32217; LYMPHOCYTE ANTIGEN 6H; 1.
DR   PANTHER; PTHR32217:SF3; LYMPHOCYTE ANTIGEN 6S; 1.
DR   Pfam; PF00021; UPAR_LY6; 1.
DR   SMART; SM00134; LU; 1.
DR   SUPFAM; SSF57302; Snake toxin-like; 1.
DR   PROSITE; PS00983; LY6_UPAR; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..105
FT                   /note="Lymphocyte antigen 6G"
FT                   /id="PRO_0000036146"
FT   PROPEP          106..134
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036147"
FT   DOMAIN          27..118
FT                   /note="UPAR/Ly6"
FT                   /evidence="ECO:0000255"
FT   LIPID           105
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        29..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..41
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        78..98
FT                   /evidence="ECO:0000250"
FT   DISULFID        99..104
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   134 AA;  14324 MW;  4D39B74495B86DE0 CRC64;
     MDTCHIAKSC VLILLVVLLC AERAQGLECY NCIGVPPETS CNTTTCPFSD GFCVALEIEV
     IVDSHRSKVK SNLCLPICPT TLDNTEITGN AVNVKTYCCK EDLCNAAVPT GGSSWTMAGV
     LLFSLVSVLL QTFL
//