ID   NHX9_CAEEL              Reviewed;         667 AA.
AC   P35449; Q95PV8; Q95PV9; Q95PW0;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2002, sequence version 2.
DT   02-SEP-2026, entry version 173.
DE   RecName: Full=Probable Na(+)/H(+) antiporter nhx-9;
DE   AltName: Full=Na(+)-H(+) exchanger protein 9;
GN   Name=nhx-9; ORFNames=ZK822.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RX   PubMed=12021279; DOI=10.1074/jbc.m203200200;
RA   Nehrke K., Melvin J.E.;
RT   "The NHX family of Na+-H+ exchangers in Caenorhabditis elegans.";
RL   J. Biol. Chem. 277:29036-29044(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 58-667 (ISOFORMS A AND B).
RC   STRAIN=Bristol N2;
RX   PubMed=8382340; DOI=10.1007/bf00277125;
RA   Marra M.A., Prasad S.S., Baillie D.L.;
RT   "Molecular analysis of two genes between let-653 and let-56 in the unc-
RT   22(IV) region of Caenorhabditis elegans.";
RL   Mol. Gen. Genet. 236:289-298(1993).
CC   -!- FUNCTION: Serves some physiological function other than regulation of
CC       cellular pH.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC       Note=Excretory cell.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=b;
CC         IsoId=P35449-1; Sequence=Displayed;
CC       Name=a;
CC         IsoId=P35449-2; Sequence=VSP_003395;
CC       Name=c;
CC         IsoId=P35449-3; Sequence=VSP_003396;
CC   -!- TISSUE SPECIFICITY: In early stage larva, expressed in the twin
CC       excretory cell processes. At later larval stages, expression is more
CC       restricted, resulting in a 'beads on a chain' appearance.
CC   -!- PTM: Phosphorylated. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000305}.
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DR   EMBL; AF497834; AAM18112.1; -; mRNA.
DR   EMBL; AF497835; AAM18113.1; -; mRNA.
DR   EMBL; Z73898; CAC42388.1; -; Genomic_DNA.
DR   EMBL; Z73898; CAC42389.1; -; Genomic_DNA.
DR   EMBL; Z73898; CAC42390.3; -; Genomic_DNA.
DR   EMBL; M23064; AAA27892.1; -; mRNA.
DR   RefSeq; NP_001023627.1; NM_001028456.5. [P35449-2]
DR   RefSeq; NP_001023628.1; NM_001028457.6. [P35449-1]
DR   RefSeq; NP_001379286.1; NM_001392404.1. [P35449-3]
DR   AlphaFoldDB; P35449; -.
DR   SMR; P35449; -.
DR   FunCoup; P35449; 239.
DR   STRING; 6239.ZK822.3b.1; -.
DR   GlyCosmos; P35449; 1 site, No reported glycans.
DR   iPTMnet; P35449; -.
DR   PaxDb; 6239-ZK822.3b.1; -.
DR   PeptideAtlas; P35449; -.
DR   EnsemblMetazoa; ZK822.3a.1; ZK822.3a.1; WBGene00003736.
DR   EnsemblMetazoa; ZK822.3b.1; ZK822.3b.1; WBGene00003736.
DR   EnsemblMetazoa; ZK822.3c.1; ZK822.3c.1; WBGene00003736.
DR   GeneID; 178126; -.
DR   KEGG; cel:CELE_ZK822.3; -.
DR   UCSC; ZK822.3b; c. elegans. [P35449-1]
DR   AGR; WB:WBGene00003736; -.
DR   CTD; 178126; -.
DR   WormBase; ZK822.3a; CE27559; WBGene00003736; nhx-9. [P35449-2]
DR   WormBase; ZK822.3b; CE27560; WBGene00003736; nhx-9. [P35449-1]
DR   WormBase; ZK822.3c; CE28196; WBGene00003736; nhx-9. [P35449-3]
DR   eggNOG; KOG1966; Eukaryota.
DR   InParanoid; P35449; -.
DR   OMA; ERYTYNT; -.
DR   OrthoDB; 196264at2759; -.
DR   PhylomeDB; P35449; -.
DR   Reactome; R-CEL-425986; Sodium/Proton exchangers.
DR   PRO; PR:P35449; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00003736; Expressed in larva and 4 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; NAS:UniProtKB.
DR   GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR   GO; GO:0098719; P:sodium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; NAS:UniProtKB.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR006153; Cation/H_exchanger_TM.
DR   InterPro; IPR004709; NaH_exchanger.
DR   NCBIfam; TIGR00840; b_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF98; SODIUM_HYDROGEN EXCHANGER; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Antiport; Cell membrane; Glycoprotein; Ion transport;
KW   Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..667
FT                   /note="Probable Na(+)/H(+) antiporter nhx-9"
FT                   /id="PRO_0000052371"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          637..667
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         644
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        310
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..60
FT                   /note="Missing (in isoform c)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_003396"
FT   VAR_SEQ         1..29
FT                   /note="MSSRLFVFFLICYATADKIEKELISDGFQ -> MGHEYDIEE (in
FT                   isoform a)"
FT                   /evidence="ECO:0000303|PubMed:12021279,
FT                   ECO:0000303|PubMed:8382340"
FT                   /id="VSP_003395"
FT   CONFLICT        111..112
FT                   /note="DA -> GSS (in Ref. 3; AAA27892)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        214..217
FT                   /note="MFKS -> CSK (in Ref. 3; AAA27892)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        415
FT                   /note="A -> R (in Ref. 3; AAA27892)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        426
FT                   /note="V -> W (in Ref. 3; AAA27892)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        625
FT                   /note="Missing (in Ref. 3; AAA27892)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   667 AA;  75281 MW;  AB4245787973135B CRC64;
     MSSRLFVFFL ICYATADKIE KELISDGFQL FTWKWDDVHH VYVITVWLLI ASLAKILFNL
     MKPISKWCPD SSLLIIVGLA LGWILHQTSL SGATLDSHTF FLYLLPPIIF DAGYFMPNRA
     LFENFDSVLV FSVFGTIWNT FAIGGSLLLM AQYDLFTMSF TTFEILVFSA LISAVDPVAV
     IAVFEEIHVN EFLFINVFGE ALFNDGVTVV LYQMFKSFAL IGSENLSVLD YATGGLSFFV
     VALGGAAVGI IFAIAASLTT KYTYDVRILA PVFIFVLPYM AYLTAEMVSL SSIIAIAICG
     MLMKQYIKGN VTQAAANSVK YFTKMLAQSS ETVIFMFLGL STISSQHHFD LYFICATLFF
     CLIYRAIGIV VQCYILNRFR AKKFEMVDQF IMSYGGLRGA IAYGLVVSIP ASITAKPMFI
     TATIAVIYFT VFLQGITIRP LVNFLKIKKK EERDPTMVES VYNKYLDYMM SGVEDIAGQK
     GHYTFIENFE RFNAKVIKPV LMRHQKRESF DASSIVRAYE KITLEDAIKL AKVKNNIQNK
     RLERIKSKGR VAPILPDKIS NQKTMTPKDL QLKRFMESGE NIDSLYTLFS DLLDRKLHEM
     NRPSVQITDV DGQDDIQDDY MAEVGSRSNL SAMFRSTEQL PSETPFHSGR RQSTGDLNAT
     RRADFNV
//