ID   CLG1_YEAST              Reviewed;         452 AA.
AC   P35190; D6VTU1;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   02-SEP-2026, entry version 162.
DE   RecName: Full=PHO85 cyclin CLG1;
DE   AltName: Full=Cyclin-like G1 protein 1;
GN   Name=CLG1; OrderedLocusNames=YGL215W; ORFNames=G1105;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8212900; DOI=10.1002/yea.320090813;
RA   Matsumoto Y., Wickner R.B.;
RT   "CLG1, a new cyclin-like gene of Saccharomyces cerevisiae.";
RL   Yeast 9:929-931(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9290212;
RX   DOI=10.1002/(sici)1097-0061(19970915)13:11<1077::aid-yea152>3.0.co;2-y;
RA   Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.;
RT   "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae
RT   chromosome VII.";
RL   Yeast 13:1077-1090(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9153757;
RX   DOI=10.1002/(sici)1097-0061(199704)13:5<475::aid-yea101>3.0.co;2-0;
RA   Feuermann M., Simeonava L., Souciet J.-L., Potier S.;
RT   "Analysis of 21.7 kb DNA sequence from the left arm of chromosome VII
RT   reveals 11 open reading frames: two correspond to new genes.";
RL   Yeast 13:475-477(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169869; DOI=10.1038/387s081;
RA   Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA   Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA   Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA   Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA   Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA   Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA   Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA   Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA   Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA   Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA   Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA   Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA   Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA   Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA   Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA   Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA   Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA   Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA   Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA   Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA   Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA   Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL   Nature 387:81-84(1997).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [6]
RP   INTERACTION WITH PHO85.
RX   PubMed=9032248; DOI=10.1128/mcb.17.3.1212;
RA   Measday V., Moore L., Retnakaran R., Lee J., Donoviel M., Neiman A.M.,
RA   Andrews B.J.;
RT   "A family of cyclin-like proteins that interact with the Pho85 cyclin-
RT   dependent kinase.";
RL   Mol. Cell. Biol. 17:1212-1223(1997).
CC   -!- FUNCTION: Cyclin partner of the cyclin-dependent kinase (CDK) PHO85.
CC       Has a role in cell integrity and polarized cell growth together with
CC       the other PCL1/PCL2 cyclin family members.
CC   -!- SUBUNIT: Forms a cyclin-CDK complex with PHO85.
CC   -!- INTERACTION:
CC       P35190; P17157: PHO85; NbExp=3; IntAct=EBI-4762, EBI-13327;
CC       P35190; P10591: SSA1; NbExp=3; IntAct=EBI-4762, EBI-8591;
CC   -!- SIMILARITY: Belongs to the cyclin family. PCL1,2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; L11612; AAA16919.1; -; mRNA.
DR   EMBL; Z72737; CAA96931.1; -; Genomic_DNA.
DR   EMBL; BK006941; DAA07902.1; -; Genomic_DNA.
DR   PIR; S37607; S37607.
DR   RefSeq; NP_011300.1; NM_001181080.1.
DR   AlphaFoldDB; P35190; -.
DR   BioGRID; 33042; 238.
DR   ComplexPortal; CPX-1693; CLG1-PHO85 kinase complex.
DR   DIP; DIP-1507N; -.
DR   FunCoup; P35190; 44.
DR   IntAct; P35190; 9.
DR   MINT; P35190; -.
DR   STRING; 4932.YGL215W; -.
DR   iPTMnet; P35190; -.
DR   PaxDb; 4932-YGL215W; -.
DR   PeptideAtlas; P35190; -.
DR   EnsemblFungi; YGL215W_mRNA; YGL215W; YGL215W.
DR   GeneID; 852657; -.
DR   KEGG; sce:YGL215W; -.
DR   AGR; SGD:S000003183; -.
DR   SGD; S000003183; CLG1.
DR   VEuPathDB; FungiDB:YGL215W; -.
DR   eggNOG; ENOG502RYK1; Eukaryota.
DR   HOGENOM; CLU_034017_0_0_1; -.
DR   InParanoid; P35190; -.
DR   OMA; MYYPNYA; -.
DR   OrthoDB; 244495at2759; -.
DR   BioCyc; YEAST:G3O-30691-MONOMER; -.
DR   BioGRID-ORCS; 852657; 2 hits in 10 CRISPR screens.
DR   PRO; PR:P35190; -.
DR   Proteomes; UP000002311; Chromosome VII.
DR   RNAct; P35190; protein.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:ComplexPortal.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IDA:SGD.
DR   GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR   GO; GO:0016239; P:positive regulation of macroautophagy; IMP:SGD.
DR   GO; GO:0051726; P:regulation of cell cycle; NAS:ComplexPortal.
DR   CDD; cd20557; CYCLIN_ScPCL1-like; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 1.
DR   InterPro; IPR013922; Cyclin_PHO80-like.
DR   PANTHER; PTHR15615; -; 1.
DR   PANTHER; PTHR15615:SF27; PHO85 CYCLIN CLG1; 1.
PE   1: Evidence at protein level;
KW   Cyclin; Reference proteome.
FT   CHAIN           1..452
FT                   /note="PHO85 cyclin CLG1"
FT                   /id="PRO_0000080503"
SQ   SEQUENCE   452 AA;  51571 MW;  579CAE1C45A2BE84 CRC64;
     MANTFKYYPE TMGNSSGYPI SLPFPKGSAT SAVNVARQLP KYLGHVPSQS VHTQLPSMAS
     LGYFNQPSST YYAPPAPLQQ HQQPPILPPP GLMYTSNNNS NVIPPPVQMI RDGQQQPQQS
     NQVNGGVSEN LDYDISIMSK FIMENAFVAF NANYSTDDQT TDLFFKGISS VLNATRLPSA
     TIFLAIDYLF KYINKLSNGI HSIGGNSINI IYQNTMIAFI LANKFNDDKT FTNNSWSQAT
     GILINVINDF ERQWLRIFNW ELYDSAFLYF EFVKNFEIFK QNQLKPAVAV PTLLSPIVNV
     GDTRNVNFNL KPTSTNNLLS PVSNYETPML MPHNMFSSPS YQSNSRSEFS SMNGYYNYYN
     YNQPRLNYYQ QFPNIYSSPI SETQFDYDFY NFSSQQQQQQ QKQHSLLPAA PQLPPPHVHN
     QSYGHHLGWK SMDDTINHSR FERNYFPYSA VY
//