ID ESS2_CAEEL Reviewed; 531 AA. AC P34420; Q6AHR6; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 25-OCT-2005, sequence version 2. DT 04-NOV-2026, entry version 155. DE RecName: Full=Splicing factor ESS-2 {ECO:0000303|PubMed:25194163}; DE AltName: Full=ES2 similar protein 2; GN Name=ess-2; ORFNames=F42H10.7; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX PubMed=7906398; DOI=10.1038/368032a0; RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A., RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., RA Wilkinson-Sproat J., Wohldman P.; RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. RT elegans."; RL Nature 368:32-38(1994). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING. RC STRAIN=Bristol N2; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). RN [3] RP SIMILARITY. RX PubMed=8703114; DOI=10.1007/s003359900197; RA Rizzu P., Lindsay E.A., Taylor C., O'Donnell H., Levy A., Scambler P.J., RA Baldini A.; RT "Cloning and comparative mapping of a gene from the commonly deleted region RT of DiGeorge and Velocardiofacial syndromes conserved in C. elegans."; RL Mamm. Genome 7:639-643(1996). RN [4] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=25194163; DOI=10.1534/genetics.114.167841; RA Noma K., Goncharov A., Jin Y.; RT "Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA RT splicing in Caenorhabditis elegans."; RL Genetics 198:1101-1115(2014). CC -!- FUNCTION: Regulates pre-mRNA splicing. {ECO:0000269|PubMed:25194163}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25194163}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=b; CC IsoId=P34420-1; Sequence=Displayed; CC Name=a; CC IsoId=P34420-2; Sequence=VSP_015951; CC -!- SIMILARITY: Belongs to the ESS2 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FO080327; CCD62885.1; -; Genomic_DNA. DR EMBL; FO080327; CCD62886.1; -; Genomic_DNA. DR PIR; S44649; S44649. DR RefSeq; NP_001022580.1; NM_001027409.6. [P34420-2] DR RefSeq; NP_001022581.1; NM_001027410.5. [P34420-1] DR AlphaFoldDB; P34420; -. DR SMR; P34420; -. DR BioGRID; 41404; 16. DR DIP; DIP-25557N; -. DR FunCoup; P34420; 2691. DR IntAct; P34420; 11. DR STRING; 6239.F42H10.7b.1; -. DR iPTMnet; P34420; -. DR PaxDb; 6239-F42H10.7b.1; -. DR PeptideAtlas; P34420; -. DR EnsemblMetazoa; F42H10.7a.1; F42H10.7a.1; WBGene00018371. DR EnsemblMetazoa; F42H10.7b.1; F42H10.7b.1; WBGene00018371. DR GeneID; 176200; -. DR KEGG; cel:CELE_F42H10.7; -. DR UCSC; F42H10.7b; c. elegans. [P34420-1] DR AGR; WB:WBGene00018371; -. DR CTD; 176200; -. DR WormBase; F42H10.7a; CE00169; WBGene00018371; ess-2. [P34420-2] DR WormBase; F42H10.7b; CE37109; WBGene00018371; ess-2. [P34420-1] DR eggNOG; KOG2627; Eukaryota. DR InParanoid; P34420; -. DR OMA; ACSMVAQ; -. DR OrthoDB; 19679at2759; -. DR PhylomeDB; P34420; -. DR SignaLink; P34420; -. DR PRO; PR:P34420; -. DR Proteomes; UP000001940; Chromosome III. DR Bgee; WBGene00018371; Expressed in germ line (C elegans) and 4 other cell types or tissues. DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IDA:WormBase. DR InterPro; IPR019148; Nuclear_protein_DGCR14_ESS-2. DR PANTHER; PTHR12940; ES-2 PROTEIN - RELATED; 1. DR PANTHER; PTHR12940:SF0; SPLICING FACTOR ESS-2 HOMOLOG; 1. DR Pfam; PF09751; Es2; 1. PE 3: Inferred from homology; KW Alternative splicing; Nucleus; Reference proteome. FT CHAIN 1..531 FT /note="Splicing factor ESS-2" FT /id="PRO_0000079874" FT REGION 104..163 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 453..531 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 105..114 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 125..136 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 464..477 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 480..498 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 412..413 FT /note="Missing (in isoform a)" FT /evidence="ECO:0000305" FT /id="VSP_015951" SQ SEQUENCE 531 AA; 58519 MW; 809E5BA29DC4173D CRC64; MSSFDKNDER AQLMVPKSIN EGKVVKLSQK TLVTKKIERQ VVPEEKYIAG LDKIIEKDYF PHLKKMQAQK EYLEAVANKD INKIKELQMK FCSTGSVRTD RSFRTPITTR STTEAPDVSS FDADTPGPSS ASTSSAHDWM QSPMPFANEE GDNEALNRKR KKKKEETLTS YLNKYTSEDN ASFEELAKVM REREDARRPW VYKAEEEHNK NLVTRQAIAA EADVQLALKH AVDADDNRPL NVDNWAYKAW NTVLFNPDGA ALTPAEIADA ARKQQTEINK RGTRFPDSGK LKPSDEAMTR AAVSHALANA GKVDFLGNEV TPANSFKLLE TPNPNPDDMD SPLMTWGEID GTPFRLDAPD VTEHSLPGAA PVFKIPEVPY REKIAQSMND SIAAKYRDKR KVAMRAAEGA HFSRTPGFGS KRVSDKLAQL SPAAQKLATK KLGLKMLPAH KSPFASPKIM SNWSRPSSSK RSTTPGSAWS RGSTTPGSSW SQGAQTPGTP GIESMIRRKG DNVGPSTSAG AADRANAGDF F //