ID   YDCF_ECOLI              Reviewed;         266 AA.
AC   P34209; P77578;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 3.
DT   04-NOV-2026, entry version 152.
DE   RecName: Full=Protein YdcF;
GN   Name=ydcF; OrderedLocusNames=b1414, JW1411;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RA   Hidalgo E., Limon A., Aguilar J.;
RT   "A third gene with high homology to gap gene in the Escherichia coli
RT   chromosome.";
RL   Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA   Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA   Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA   Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA   Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA   Wada C., Yamamoto Y., Horiuchi T.;
RT   "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 28.0-40.1 min region on the linkage map.";
RL   DNA Res. 3:363-377(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=B / BL21;
RX   PubMed=10493123;
RX   DOI=10.1002/(sici)1522-2683(19990801)20:11<2181::aid-elps2181>3.0.co;2-q;
RA   Fountoulakis M., Takacs M.-F., Berndt P., Langen H., Takacs B.;
RT   "Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite
RT   chromatography.";
RL   Electrophoresis 20:2181-2195(1999).
RN   [6]
RP   X-RAY CRYSTALLOGRAPHY, SUBUNIT, AND S-ADENOSYL-L-METHIONINE BINDING.
RX   PubMed=18393394; DOI=10.1002/prot.22046;
RA   Chao K.L., Lim K., Lehmann C., Doseeva V., Howard A.J., Schwarz F.P.,
RA   Herzberg O.;
RT   "The Escherichia coli YdcF binds S-adenosyl-L-methionine and adopts an
RT   alpha/beta-fold characteristic of nucleotide-utilizing enzymes.";
RL   Proteins 72:506-509(2008).
CC   -!- FUNCTION: Binds S-adenosyl-L-methionine (AdoMet).
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:18393394}.
CC   -!- SIMILARITY: To S.coelicolor SCO4629. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA24246.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L09068; AAA24246.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; U00096; AAC74496.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15030.1; -; Genomic_DNA.
DR   PIR; A64893; A64893.
DR   RefSeq; NP_415932.1; NC_000913.3.
DR   RefSeq; WP_001027942.1; NZ_CP009789.1.
DR   PDB; 3CA8; X-ray; 1.80 A; A/B=1-266.
DR   AlphaFoldDB; P34209; -.
DR   SMR; P34209; -.
DR   BioGRID; 4261553; 11.
DR   BioGRID; 850575; 1.
DR   DIP; DIP-11642N; -.
DR   FunCoup; P34209; 3.
DR   IntAct; P34209; 2.
DR   STRING; 511145.b1414; -.
DR   jPOST; P34209; -.
DR   PaxDb; 511145-b1414; -.
DR   EnsemblBacteria; AAC74496; AAC74496; b1414.
DR   GeneID; 75203495; -.
DR   GeneID; 946215; -.
DR   KEGG; ecj:JW1411; -.
DR   KEGG; eco:b1414; -.
DR   KEGG; ecoc:C3026_08235; -.
DR   PATRIC; fig|1411691.4.peg.857; -.
DR   EchoBASE; EB2033; -.
DR   eggNOG; COG1434; Bacteria.
DR   HOGENOM; CLU_084257_0_0_6; -.
DR   InParanoid; P34209; -.
DR   OMA; ACFDRVY; -.
DR   OrthoDB; 2216870at2; -.
DR   PhylomeDB; P34209; -.
DR   BioCyc; EcoCyc:EG12110-MONOMER; -.
DR   EvolutionaryTrace; P34209; -.
DR   PRO; PR:P34209; -.
DR   Proteomes; UP000000625; Chromosome.
DR   CDD; cd06259; YdcF-like; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 1.10.3620.10; YdcF like domain; 1.
DR   InterPro; IPR051599; Cell_Envelope_Assoc.
DR   InterPro; IPR003848; DUF218.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR30336:SF20; DUF218 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR30336; INNER MEMBRANE PROTEIN, PROBABLE PERMEASE; 1.
DR   Pfam; PF02698; DUF218; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome.
FT   CHAIN           1..266
FT                   /note="Protein YdcF"
FT                   /id="PRO_0000168929"
FT   CONFLICT        97
FT                   /note="A -> R (in Ref. 1; AAA24246)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        217..266
FT                   /note="PRLRDDSDGYGPRGRDFIVHVDFPAEVIHAWQTLKHDAVLIEAMESRSLR
FT                   -> RVYAMIAMATVPAGEILSFTLIFRQKSSMHGKR (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   HELIX           11..25
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   TURN            29..32
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   STRAND          38..44
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   HELIX           48..61
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   STRAND          65..68
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   HELIX           75..83
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   HELIX           88..90
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   HELIX           98..104
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   HELIX           105..109
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   HELIX           114..116
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   STRAND          117..120
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   HELIX           126..138
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   STRAND          147..150
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   TURN            153..155
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   HELIX           156..167
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   STRAND          175..178
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   STRAND          186..189
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   STRAND          192..197
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   HELIX           205..219
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   STRAND          225..227
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   TURN            228..231
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   HELIX           241..251
FT                   /evidence="ECO:0007829|PDB:3CA8"
FT   HELIX           254..262
FT                   /evidence="ECO:0007829|PDB:3CA8"
SQ   SEQUENCE   266 AA;  29706 MW;  DA59CFB3D34728A5 CRC64;
     MNITPFPTLS PATIDAINVI GQWLAQDDFS GEVPYQADCV ILAGNAVMPT IDAACKIARD
     QQIPLLISGG IGHSTTFLYS AIAQHPHYNT IRTTGRAEAT ILADIAHQFW HIPHEKIWIE
     DQSTNCGENA RFSIALLNQA VERVHTAIVV QDPTMQRRTM ATFRRMTGDN PDAPRWLSYP
     GFVPQLGNNA DSVIFINQLQ GLWPVERYLS LLTGELPRLR DDSDGYGPRG RDFIVHVDFP
     AEVIHAWQTL KHDAVLIEAM ESRSLR
//