ID   SGRR_ECOLI              Reviewed;         551 AA.
AC   P33595; P75638;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2003, sequence version 2.
DT   02-SEP-2026, entry version 173.
DE   RecName: Full=HTH-type transcriptional regulator SgrR;
GN   Name=sgrR; Synonyms=yabN; OrderedLocusNames=b0069, JW0068;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12;
RX   PubMed=1630901; DOI=10.1093/nar/20.13.3305;
RA   Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K.,
RA   Mizobuchi K., Nakata A.;
RT   "Systematic sequencing of the Escherichia coli genome: analysis of the
RT   0-2.4 min region.";
RL   Nucleic Acids Res. 20:3305-3308(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO
RP   356; 384 AND 409.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   FUNCTION AS A TRANSCRIPTIONAL REGULATOR.
RX   PubMed=15522088; DOI=10.1111/j.1365-2958.2004.04348.x;
RA   Vanderpool C.K., Gottesman S.;
RT   "Involvement of a novel transcriptional activator and small RNA in post-
RT   transcriptional regulation of the glucose phosphoenolpyruvate
RT   phosphotransferase system.";
RL   Mol. Microbiol. 54:1076-1089(2004).
RN   [5]
RP   FUNCTION AS A TRANSCRIPTIONAL REGULATOR.
RX   PubMed=17209026; DOI=10.1128/jb.01689-06;
RA   Vanderpool C.K., Gottesman S.;
RT   "The novel transcription factor SgrR coordinates the response to glucose-
RT   phosphate stress.";
RL   J. Bacteriol. 189:2238-2248(2007).
CC   -!- FUNCTION: Activates the small RNA gene sgrS under glucose-phosphate
CC       stress conditions as well as yfdZ. Represses its own transcription
CC       under both stress and non-stress conditions; this repression likely
CC       provides one measure of control over sgrR at the level of synthesis.
CC       Might act as a sensor of the intracellular accumulation of
CC       phosphoglucose by binding these molecules in its C-terminal solute-
CC       binding domain. {ECO:0000269|PubMed:15522088,
CC       ECO:0000269|PubMed:17209026}.
CC   -!- MISCELLANEOUS: Binds specifically to sgrS promoter in vitro.
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DR   EMBL; U00096; AAC73180.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAB96638.2; -; Genomic_DNA.
DR   PIR; E64728; E64728.
DR   RefSeq; NP_414611.1; NC_000913.3.
DR   RefSeq; WP_001138624.1; NZ_CP009789.1.
DR   AlphaFoldDB; P33595; -.
DR   SMR; P33595; -.
DR   BioGRID; 4263126; 138.
DR   FunCoup; P33595; 61.
DR   IntAct; P33595; 2.
DR   STRING; 511145.b0069; -.
DR   jPOST; P33595; -.
DR   PaxDb; 511145-b0069; -.
DR   EnsemblBacteria; AAC73180; AAC73180; b0069.
DR   GeneID; 944788; -.
DR   KEGG; ecj:JW0068; -.
DR   KEGG; eco:b0069; -.
DR   PATRIC; fig|1411691.4.peg.2213; -.
DR   EchoBASE; EB2018; -.
DR   eggNOG; COG4533; Bacteria.
DR   HOGENOM; CLU_017028_12_3_6; -.
DR   InParanoid; P33595; -.
DR   OMA; WLTWQAE; -.
DR   OrthoDB; 5894719at2; -.
DR   PhylomeDB; P33595; -.
DR   BioCyc; EcoCyc:EG12094-MONOMER; -.
DR   PRO; PR:P33595; -.
DR   Proteomes; UP000000625; Chromosome.
DR   AbasyAtlas; P33595; -.
DR   GO; GO:1904680; F:peptide transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:EcoCyc.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IMP:EcoCyc.
DR   GO; GO:0015833; P:peptide transport; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IMP:EcoCyc.
DR   CDD; cd08507; PBP2_SgrR_like; 1.
DR   FunFam; 3.40.190.10:FF:000070; HTH-type transcriptional regulator SgrR; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR   HAMAP; MF_01449; HTH_type_SgrR; 1.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR000914; SBP_5_dom.
DR   InterPro; IPR025370; SgrR_HTH_N.
DR   InterPro; IPR023767; Tscrpt_reg_SgrR.
DR   NCBIfam; NF010149; PRK13626.1; 1.
DR   PANTHER; PTHR30290:SF72; HTH-TYPE TRANSCRIPTIONAL REGULATOR SGRR; 1.
DR   PANTHER; PTHR30290; PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   Pfam; PF12793; SgrR_N; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..551
FT                   /note="HTH-type transcriptional regulator SgrR"
FT                   /id="PRO_0000168522"
FT   DOMAIN          1..116
FT                   /note="HTH marR-type"
FT   DNA_BIND        26..49
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   REGION          163..492
FT                   /note="Solute-binding"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   551 AA;  63975 MW;  0F4FAA1AAFC4E731 CRC64;
     MPSARLQQQF IRLWQCCEGK SQDTTLNELA ALLSCSRRHM RTLLNTMQDR GWLTWEAEVG
     RGKRSRLTFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK ATVRQMLVSH LGRSFRQGRH
     ILRVLYYRPL RNLLPGSALR RSETHIARQI FSSLTRINEE NGELEADIAH HWQQISPLHW
     RFFLRPGVHF HHGRELEMDD VIASLKRINT LPLYSHIADI VSPTPWTLDI HLTQPDRWLP
     LLLGQVPAMI LPREWETLSN FASHPIGTGP YAVIRNSTNQ LKIQAFDDFF GYRALIDEVN
     VWVLPEIADE PAGGLMLKGP QGEEKEIESR LEEGCYYLLF DSRTHRGANQ QVRDWVSYVL
     SPTNLVYFAE EQYQQLWFPA YGLLPRWHHA RTIKSEKPAG LESLTLTFYQ DHSEHRVIAG
     IMQQILASHQ VTLKIKEIDY DQWHTGEIES DIWLNSANFT LPLDFSVFAH LCEVPLLQHC
     IPIDWQADAA RWRNGEMNLA NWCQQLVASK AMVPLLHHWL IIQGQRSMRG LRMNTLGWFD
     FKSAWFAPPD P
//