ID   MOKC_ECOLI              Reviewed;          69 AA.
AC   P33236;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   02-SEP-2026, entry version 123.
DE   RecName: Full=Regulatory protein MokC;
GN   Name=mokC; Synonyms=gefL; OrderedLocusNames=b0018, JW5879;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1943701; DOI=10.1111/j.1365-2958.1991.tb01911.x;
RA   Poulsen L.K., Refn A., Molin S., Andersson P.;
RT   "The gef gene from Escherichia coli is regulated at the level of
RT   translation.";
RL   Mol. Microbiol. 5:1639-1648(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   PROBABLE FUNCTION.
RX   PubMed=10361310; DOI=10.1046/j.1365-2958.1999.01431.x;
RA   Pedersen K., Gerdes K.;
RT   "Multiple hok genes on the chromosome of Escherichia coli.";
RL   Mol. Microbiol. 32:1090-1102(1999).
CC   -!- FUNCTION: Might be the toxic component of a type I toxin-antitoxin (TA)
CC       system (By similarity). Regulatory peptide which completely overlaps
CC       hokC and enables hokC expression. {ECO:0000250|UniProtKB:P0ACG4,
CC       ECO:0000305|PubMed:10361310}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0ACG4}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Hok/Gef family. {ECO:0000305}.
CC   -!- CAUTION: Was originally described as a gef leader peptide.
CC       {ECO:0000305|PubMed:1943701}.
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DR   EMBL; U00096; AAC73129.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAB96591.1; -; Genomic_DNA.
DR   RefSeq; NP_414559.1; NC_000913.3.
DR   AlphaFoldDB; P33236; -.
DR   SMR; P33236; -.
DR   FunCoup; P33236; 74.
DR   STRING; 511145.b0018; -.
DR   PaxDb; 511145-b0018; -.
DR   EnsemblBacteria; AAC73129; AAC73129; b0018.
DR   GeneID; 944756; -.
DR   KEGG; ecj:JW5879; -.
DR   KEGG; eco:b0018; -.
DR   PATRIC; fig|83333.113.peg.18; -.
DR   EchoBASE; EB1999; -.
DR   eggNOG; ENOG50325FR; Bacteria.
DR   eggNOG; ENOG50339QC; Bacteria.
DR   HOGENOM; CLU_177638_2_0_6; -.
DR   InParanoid; P33236; -.
DR   OMA; QHKVMIV; -.
DR   OrthoDB; 6556178at2; -.
DR   PhylomeDB; P33236; -.
DR   BioCyc; EcoCyc:EG10373-MONOMER; -.
DR   PRO; PR:P33236; -.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   InterPro; IPR000021; Hok/gef_toxin.
DR   InterPro; IPR018084; Hok/gef_toxin_CS.
DR   Pfam; PF01848; HOK_GEF; 1.
DR   PRINTS; PR00281; HOKGEFTOXIC.
DR   PROSITE; PS00556; HOK_GEF; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Toxin-antitoxin system; Transmembrane; Transmembrane helix.
FT   CHAIN           1..69
FT                   /note="Regulatory protein MokC"
FT                   /id="PRO_0000044031"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   69 AA;  7742 MW;  ED07A98BE0F165B4 CRC64;
     MLNTCRVPLT DRKVKEKRAM KQHKAMIVAL IVICITAVVA ALVTRKDLCE VHIRTGQTEV
     AVFTAYESE
//