ID TNFL8_MOUSE Reviewed; 239 AA. AC P32972; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 04-NOV-2026, entry version 156. DE RecName: Full=Tumor necrosis factor ligand superfamily member 8; DE AltName: Full=CD30 ligand; DE Short=CD30-L; DE AltName: CD_antigen=CD153; GN Name=Tnfsf8; Synonyms=Cd30l, Cd30lg; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=T-cell; RX PubMed=8391931; DOI=10.1016/0092-8674(93)90361-s; RA Smith C.A., Gruess H.-J., Davis T., Anderson D., Farrah T., Baker E., RA Sutherland G.R., Brannan C.I., Copeland N.G., Jenkins N.A., Grabstein K.H., RA Gliniak B., McAlister I.B., Fanslow W., Alderson M., Falk B., Gimpsel S., RA Gillis S., Din W.S., Goodwin R.G., Armitage R.J.; RT "CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand RT defines an emerging family of cytokines with homology to TNF."; RL Cell 73:1349-1360(1993). CC -!- FUNCTION: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of CC T-cells. CC -!- SUBUNIT: Homotrimer. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L09754; AAA74595.1; -; mRNA. DR CCDS; CCDS18264.1; -. DR PIR; B40710; B40710. DR RefSeq; NP_033429.1; NM_009403.3. DR AlphaFoldDB; P32972; -. DR SMR; P32972; -. DR FunCoup; P32972; 314. DR STRING; 10090.ENSMUSP00000030047; -. DR GlyCosmos; P32972; 6 sites, No reported glycans. DR GlyGen; P32972; 6 sites, 1 N-linked glycan (1 site). DR PhosphoSitePlus; P32972; -. DR PaxDb; 10090-ENSMUSP00000030047; -. DR Antibodypedia; 15592; 549 antibodies from 33 providers. DR DNASU; 21949; -. DR Ensembl; ENSMPUT00000001700; ENSMPUP00000001666; ENSMPUG00000001682. DR Ensembl; ENSMUST00000030047.3; ENSMUSP00000030047.3; ENSMUSG00000028362.3. DR GeneID; 21949; -. DR KEGG; mmu:21949; -. DR UCSC; uc008thd.1; mouse. DR AGR; MGI:88328; -. DR CTD; 944; -. DR MGI; MGI:88328; Tnfsf8. DR VEuPathDB; HostDB:ENSMUSG00000028362; -. DR eggNOG; ENOG502S54A; Eukaryota. DR GeneTree; ENSGT00390000011719; -. DR HOGENOM; CLU_102229_0_0_1; -. DR InParanoid; P32972; -. DR OMA; AFMQVNC; -. DR OrthoDB; 9908372at2759; -. DR PhylomeDB; P32972; -. DR Reactome; R-MMU-5669034; TNFs bind their physiological receptors. DR BioGRID-ORCS; 21949; 2 hits in 77 CRISPR screens. DR PRO; PR:P32972; -. DR Proteomes; UP000000589; Chromosome 4. DR RNAct; P32972; protein. DR Bgee; ENSMUSG00000028362; Expressed in kidney vasculature and 17 other cell types or tissues. DR ExpressionAtlas; P32972; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro. DR GO; GO:0043374; P:CD8-positive, alpha-beta T cell differentiation; IMP:MGI. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI. DR CDD; cd00184; TNF; 1. DR FunFam; 2.60.120.40:FF:000023; tumor necrosis factor ligand superfamily member 8; 1. DR Gene3D; 2.60.120.40; -; 1. DR InterPro; IPR021185; TNF_CD30_ligand_type. DR InterPro; IPR021184; TNF_CS. DR InterPro; IPR006052; TNF_dom. DR InterPro; IPR053104; TNF_ligand_SF_member_8. DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom. DR PANTHER; PTHR32163; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 8; 1. DR PANTHER; PTHR32163:SF1; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 8; 1. DR Pfam; PF00229; TNF; 1. DR PIRSF; PIRSF019548; TNF_CD30_ligand_type; 1. DR SMART; SM00207; TNF; 1. DR SUPFAM; SSF49842; TNF-like; 1. DR PROSITE; PS00251; THD_1; 1. DR PROSITE; PS50049; THD_2; 1. PE 2: Evidence at transcript level; KW Cytokine; Disulfide bond; Glycoprotein; Membrane; Reference proteome; KW Signal-anchor; Transmembrane; Transmembrane helix. FT CHAIN 1..239 FT /note="Tumor necrosis factor ligand superfamily member 8" FT /id="PRO_0000185500" FT TOPO_DOM 1..43 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 44..67 FT /note="Helical; Signal-anchor for type II membrane protein" FT /evidence="ECO:0000255" FT TOPO_DOM 68..239 FT /note="Extracellular" FT /evidence="ECO:0000255" FT DOMAIN 103..230 FT /note="THD" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01387" FT REGION 1..36 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 75 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 86 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 114 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 158 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 194 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 206 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 156..182 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01387" SQ SEQUENCE 239 AA; 26519 MW; 29003157DD425159 CRC64; MEPGLQQAGS CGAPSPDPAM QVQPGSVASP WRSTRPWRST SRSYFYLSTT ALVCLVVAVA IILVLVVQKK DSTPNTTEKA PLKGGNCSED LFCTLKSTPS KKSWAYLQVS KHLNNTKLSW NEDGTIHGLI YQDGNLIVQF PGLYFIVCQL QFLVQCSNHS VDLTLQLLIN SKIKKQTLVT VCESGVQSKN IYQNLSQFLL HYLQVNSTIS VRVDNFQYVD TNTFPLDNVL SVFLYSSSD //