ID   HXD11_HUMAN             Reviewed;         338 AA.
AC   P31277; A6NIS4; Q9NS02;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 3.
DT   04-NOV-2026, entry version 203.
DE   RecName: Full=Homeobox protein Hox-D11;
DE   AltName: Full=Homeobox protein Hox-4F;
GN   Name=HOXD11; Synonyms=HOX4F;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Miwa N., Yoshiura K., Kantaputra P.K., Soeda E., Niikawa N.;
RT   "The role of HOXD11 and HOXD12 for the mesomelic dysplasia Kantaptra
RT   type.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-331.
RX   PubMed=2574852; DOI=10.1093/nar/17.24.10385;
RA   Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E.,
RA   Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.;
RT   "The human HOX gene family.";
RL   Nucleic Acids Res. 17:10385-10402(1989).
RN   [4]
RP   VARIANT ASP-245.
RX   PubMed=17236141; DOI=10.1086/511387;
RA   Zhao X., Sun M., Zhao J., Leyva J.A., Zhu H., Yang W., Zeng X., Ao Y.,
RA   Liu Q., Liu G., Lo W.H.Y., Jabs E.W., Amzel L.M., Shan X., Zhang X.;
RT   "Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-
RT   syndactyly syndrome.";
RL   Am. J. Hum. Genet. 80:361-371(2007).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AF154915; AAF79045.1; -; Genomic_DNA.
DR   EMBL; AC009336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS2265.1; -.
DR   PIR; S14938; S14938.
DR   RefSeq; NP_067015.2; NM_021192.3.
DR   SMR; P31277; -.
DR   BioGRID; 109477; 25.
DR   IntAct; P31277; 6.
DR   STRING; 9606.ENSP00000249504; -.
DR   NDEx; IQUERY-CP-HOXD11; 3 NDEx IQuery Curated Pathways.
DR   GlyCosmos; P31277; 1 site, 1 glycan.
DR   GlyGen; P31277; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P31277; -.
DR   PhosphoSitePlus; P31277; -.
DR   BioMuta; HOXD11; -.
DR   DMDM; 223590220; -.
DR   PaxDb; 9606-ENSP00000249504; -.
DR   PeptideAtlas; P31277; -.
DR   ProteomicsDB; 54777; -.
DR   Pumba; P31277; -.
DR   jPOST; P31277; -.
DR   MassIVE; P31277; -.
DR   DNASU; 3237; -.
DR   Ensembl; ENST00000249504.7; ENSP00000249504.5; ENSG00000128713.14.
DR   GeneID; 3237; -.
DR   KEGG; hsa:3237; -.
DR   MANE-Select; ENST00000249504.7; ENSP00000249504.5; NM_021192.3; NP_067015.2.
DR   UCSC; uc002uki.4; human.
DR   CTD; 3237; -.
DR   DisGeNET; 3237; -.
DR   VEuPathDB; HostDB:ENSG00000128713; -.
DR   GeneCards; HOXD11; -.
DR   HGNC; HGNC:5134; HOXD11.
DR   AGR; HGNC:5134; -.
DR   HPA; ENSG00000128713; Tissue enhanced (cervix, endometrium, intestine, kidney, vagina).
DR   MIM; 142986; gene.
DR   OpenTargets; ENSG00000128713; -.
DR   ClinPGx; PA29408; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000161308; -.
DR   HOGENOM; CLU_079662_0_0_1; -.
DR   InParanoid; P31277; -.
DR   OMA; AACNKHT; -.
DR   OrthoDB; 6159439at2759; -.
DR   PhylomeDB; P31277; -.
DR   Reactome; R-HSA-9830674; Formation of the ureteric bud.
DR   SignaLink; P31277; -.
DR   SIGNOR; P31277; -.
DR   ChiTaRS; HOXD11; human.
DR   GeneWiki; HOXD11; -.
DR   GenomeRNAi; 3237; -.
DR   PRO; PR:P31277; -.
DR   Bgee; ENSG00000128713; Expressed in body of uterus and 53 other cell types or tissues.
DR   CDD; cd00086; homeodomain; 1.
DR   FunFam; 1.10.10.60:FF:000166; homeobox protein Hox-C11; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR021918; DUF3528.
DR   InterPro; IPR001356; HD.
DR   InterPro; IPR020479; HD_metazoa.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR009057; Homeodomain-like_sf.
DR   PANTHER; PTHR46092; HOMEOBOX PROTEIN HOX-A11-RELATED; 1.
DR   PANTHER; PTHR46092:SF2; HOMEOBOX PROTEIN HOX-D11; 1.
DR   Pfam; PF12045; DUF3528; 2.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR   GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Proteomes; UP000005640; Chromosome 2.
DR   PathwayCommons; P31277; -.
DR   Pharos; P31277; Tbio.
DR   Antibodypedia; 33904; 329 antibodies from 31 providers.
DR   RNAct; P31277; protein.
DR   BioGRID-ORCS; 3237; 30 hits in 1169 CRISPR screens.
DR   AlphaFoldDB; P31277; -.
DR   FunCoup; P31277; 787.
DR   PAN-GO; P31277; 5 GO annotations based on evolutionary models.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Proteomics identification; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..338
FT                   /note="Homeobox protein Hox-D11"
FT                   /id="PRO_0000200231"
FT   DNA_BIND        266..325
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          179..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..204
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        239..250
FT                   /note="Gly residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         245
FT                   /note="G -> D (in dbSNP:rs376305712)"
FT                   /evidence="ECO:0000269|PubMed:17236141"
FT                   /id="VAR_031647"
FT   CONFLICT        196..205
FT                   /note="PPPPAPPQPE -> RRHPRRHSPM (in Ref. 1; AAF79045)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   338 AA;  35197 MW;  2960C3C983EA9A6A CRC64;
     MNDFDECGQS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN LAPHVQPVRE
     VAFRDYGLER AKWPYRGGGG GGSAGGGSSG GGPGGGGGGA GGYAPYYAAA AAAAAAAAAA
     EEAAMQRELL PPAGRRPDVL FKAPEPVCAA PGPPHGPAGA ASNFYSAVGR NGILPQGFDQ
     FYEAAPGPPF AGPQPPPPPA PPQPEGAADK GDPRTGAGGG GGSPCTKATP GSEPKGAAEG
     SGGDGEGPPG EAGAEKSSSA VAPQRSRKKR CPYTKYQIRE LEREFFFNVY INKEKRLQLS
     RMLNLTDRQV KIWFQNRRMK EKKLNRDRLQ YFTGNPLF
//