ID HXA2_RAT Reviewed; 372 AA. AC P31246; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1993, sequence version 1. DT 02-SEP-2026, entry version 160. DE RecName: Full=Homeobox protein Hox-A2; DE AltName: Full=Homeobox protein Hox-1.11; GN Name=Hoxa2; Synonyms=Hox-1.11, Hoxa-2; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Aorta; RX PubMed=1361191; DOI=10.1016/s0021-9258(18)35720-x; RA Patel C.V., Gorski D.H., Lepage D.F., Lincecum J., Walsh K.; RT "Molecular cloning of a homeobox transcription factor from adult aortic RT smooth muscle."; RL J. Biol. Chem. 267:26085-26090(1992). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=7915120; RA Gorski D.H., LePage D.F., Walsh K.; RT "Cloning and sequence analysis of homeobox transcription factor cDNAs with RT an inosine-containing probe."; RL BioTechniques 16:856-858(1994). CC -!- FUNCTION: Sequence-specific transcription factor which is part of a CC developmental regulatory system that provides cells with specific CC positional identities on the anterior-posterior axis. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M91802; AAA67846.1; -; mRNA. DR PIR; I52196; I52196. DR RefSeq; NP_036713.2; NM_012581.3. DR AlphaFoldDB; P31246; -. DR SMR; P31246; -. DR FunCoup; P31246; 114. DR STRING; 10116.ENSRNOP00000008023; -. DR PhosphoSitePlus; P31246; -. DR PaxDb; 10116-ENSRNOP00000008023; -. DR GeneID; 103690123; -. DR KEGG; rno:103690123; -. DR UCSC; RGD:2813; rat. DR AGR; RGD:11468112; -. DR CTD; 3199; -. DR RGD; 11468112; Hoxa2. DR eggNOG; KOG0489; Eukaryota. DR InParanoid; P31246; -. DR OrthoDB; 6159439at2759; -. DR PhylomeDB; P31246; -. DR PRO; PR:P31246; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005634; C:nucleus; ISO:RGD. DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:RGD. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD. DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD. DR GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD. DR GO; GO:0035284; P:brain segmentation; ISO:RGD. DR GO; GO:0045165; P:cell fate commitment; ISO:RGD. DR GO; GO:0001709; P:cell fate determination; ISO:RGD. DR GO; GO:0071300; P:cellular response to retinoic acid; ISO:RGD. DR GO; GO:0009953; P:dorsal/ventral pattern formation; ISO:RGD. DR GO; GO:0048706; P:embryonic skeletal system development; ISO:RGD. DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISO:RGD. DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; ISO:RGD. DR GO; GO:0042474; P:middle ear morphogenesis; ISO:RGD. DR GO; GO:0008045; P:motor neuron axon guidance; ISO:RGD. DR GO; GO:0061061; P:muscle structure development; ISO:RGD. DR GO; GO:0045665; P:negative regulation of neuron differentiation; ISO:RGD. DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; ISO:RGD. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD. DR GO; GO:0002076; P:osteoblast development; ISO:RGD. DR GO; GO:0007389; P:pattern specification process; ISO:RGD. DR GO; GO:0060037; P:pharyngeal system development; ISO:RGD. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0021568; P:rhombomere 2 development; ISO:RGD. DR GO; GO:0021569; P:rhombomere 3 development; ISO:RGD. DR GO; GO:0021658; P:rhombomere 3 morphogenesis; ISO:RGD. DR GO; GO:0007379; P:segment specification; ISO:RGD. DR CDD; cd00086; homeodomain; 1. DR FunFam; 1.10.10.60:FF:000145; homeobox protein Hox-A2; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR001356; HD. DR InterPro; IPR020479; HD_metazoa. DR InterPro; IPR001827; Homeobox_Antennapedia_CS. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR009057; Homeodomain-like_sf. DR PANTHER; PTHR45664:SF3; HOMEOBOX PROTEIN HOX-A2; 1. DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1. DR Pfam; PF00046; Homeodomain; 1. DR PRINTS; PR00024; HOMEOBOX. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00032; ANTENNAPEDIA; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 2: Evidence at transcript level; KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome; KW Transcription; Transcription regulation. FT CHAIN 1..372 FT /note="Homeobox protein Hox-A2" FT /id="PRO_0000200038" FT DNA_BIND 139..198 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 42..96 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 194..225 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 96..101 FT /note="Antp-type hexapeptide" SQ SEQUENCE 372 AA; 40827 MW; FDBBD71D55A9F19A CRC64; MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN PGSHPRQSAG AGGRPKSSPA GSRGSPVPAR ALQPPEYPWM KEKKAAKKTA LPPAAASTGP ACLGHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL EREGYTFQQN ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN CGAGLNNDSP EALEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLGSPVDI SADSFDFFTD TLTTIDLQHL NY //