ID   CCMA_BRADU              Reviewed;         200 AA.
AC   P30963;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   04-NOV-2026, entry version 156.
DE   RecName: Full=Cytochrome c biogenesis ATP-binding export protein CcmA {ECO:0000255|HAMAP-Rule:MF_01707};
DE            EC=7.6.2.5 {ECO:0000255|HAMAP-Rule:MF_01707};
DE   AltName: Full=Heme exporter protein A {ECO:0000255|HAMAP-Rule:MF_01707};
GN   Name=ccmA {ECO:0000255|HAMAP-Rule:MF_01707}; Synonyms=cycV;
GN   OrderedLocusNames=blr0467;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC   Hyphomicrobiales; Nitrobacteraceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=USDA 110RIF15;
RX   PubMed=1850420; DOI=10.1016/s0021-9258(20)89520-9;
RA   Ramseier T.M., Winteler H.V., Hennecke H.;
RT   "Discovery and sequence analysis of bacterial genes involved in the
RT   biogenesis of c-type cytochromes.";
RL   J. Biol. Chem. 266:7793-7803(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- FUNCTION: Part of the ABC transporter complex CcmAB involved in the
CC       biogenesis of c-type cytochromes; once thought to export heme, this
CC       does not seem to be the case, but its exact role is uncertain.
CC       Responsible for energy coupling to the transport system.
CC       {ECO:0000255|HAMAP-Rule:MF_01707}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H(+);
CC         Xref=Rhea:RHEA:19261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60344,
CC         ChEBI:CHEBI:456216; EC=7.6.2.5; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01707};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (CcmA) and
CC       two transmembrane proteins (CcmB). {ECO:0000255|HAMAP-Rule:MF_01707}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01707}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01707}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. CcmA exporter
CC       (TC 3.A.1.107) family. {ECO:0000255|HAMAP-Rule:MF_01707}.
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DR   EMBL; M60874; AAA26192.1; -; Genomic_DNA.
DR   EMBL; BA000040; BAC45732.1; -; Genomic_DNA.
DR   PIR; A39741; A39741.
DR   RefSeq; WP_011083298.1; NC_004463.1.
DR   SMR; P30963; -.
DR   STRING; 224911.AAV28_41585; -.
DR   TCDB; 3.A.1.107.1; the atp-binding cassette (abc) superfamily.
DR   PaxDb; 224911-AAV28_41585; -.
DR   EnsemblBacteria; BAC45732; BAC45732; BAC45732.
DR   GeneID; 46495613; -.
DR   KEGG; bja:blr0467; -.
DR   PATRIC; fig|224911.44.peg.9000; -.
DR   eggNOG; COG4133; Bacteria.
DR   HOGENOM; CLU_000604_1_2_5; -.
DR   InParanoid; P30963; -.
DR   OMA; ACHYLST; -.
DR   OrthoDB; 9800654at2; -.
DR   PhylomeDB; P30963; -.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR005895; ABC_transptr_haem_export_CcmA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43499; ABC TRANSPORTER I FAMILY MEMBER 1; 1.
DR   PANTHER; PTHR43499:SF1; ABC TRANSPORTER I FAMILY MEMBER 1; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   NCBIfam; TIGR01189; ccmA; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51243; CCMA; 1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015439; F:ABC-type heme transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:1903607; P:cytochrome c biosynthetic process; IBA:GO_Central.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:InterPro.
DR   Proteomes; UP000002526; Chromosome.
DR   AlphaFoldDB; P30963; -.
DR   FunCoup; P30963; 287.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane;
KW   Cytochrome c-type biogenesis; Membrane; Nucleotide-binding;
KW   Reference proteome; Translocase; Transport.
FT   CHAIN           1..200
FT                   /note="Cytochrome c biogenesis ATP-binding export protein
FT                   CcmA"
FT                   /id="PRO_0000092173"
FT   DOMAIN          3..199
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01707"
FT   BINDING         35..42
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01707"
SQ   SEQUENCE   200 AA;  21132 MW;  96EC3BB0C0D3141B CRC64;
     MQLSGRRVIC VRGGREVFAG LDFEAVSGEA VAVVGRNGSG KTSLLRLIAG LLIPAGGTIA
     LDGGDAELTL PEQCHYLGHR DALKPALSVA ENLSFWADFL GGERLDAHES LATVGLDHAT
     HLPAAFLSAG QRRRLSLARL LTVRRPIWLL DEPTTALDVA GQDMFGGLMR DHLARGGLII
     AATHMALGID SRELRIGGVA
//