ID   STRO_STRGR              Reviewed;         259 AA.
AC   P29785;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   28-JAN-2026, entry version 87.
DE   RecName: Full=Glucose-1-phosphate thymidylyltransferase;
DE            EC=2.7.7.24;
DE   AltName: Full=dTDP-glucose synthase;
GN   Name=strO;
OS   Streptomyces griseus.
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO 33.
RC   STRAIN=N2-3-11;
RA   Ahlert J., Distler J., Mansouri K., Roggel M., Altenbach H.J.,
RA   Piepersberg W.;
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-83.
RC   STRAIN=N2-3-11;
RX   PubMed=1661369; DOI=10.1007/bf00293829;
RA   Pissowotzki K., Mansouri K., Piepersberg W.;
RT   "Genetics of streptomycin production in Streptomyces griseus: molecular
RT   structure and putative function of genes strELMB2N.";
RL   Mol. Gen. Genet. 231:113-123(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTTP + alpha-D-glucose 1-phosphate + H(+) = dTDP-alpha-D-
CC         glucose + diphosphate; Xref=Rhea:RHEA:15225, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37568, ChEBI:CHEBI:57477,
CC         ChEBI:CHEBI:58601; EC=2.7.7.24;
CC   -!- PATHWAY: Antibiotic biosynthesis; streptomycin biosynthesis.
CC   -!- SIMILARITY: Belongs to the inositol monophosphatase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; Y08763; CAA70009.1; -; Genomic_DNA.
DR   EMBL; X62567; CAA44446.1; ALT_SEQ; Genomic_DNA.
DR   PIR; S19785; S19785.
DR   RefSeq; WP_003970231.1; NZ_BAABSR010000033.1.
DR   AlphaFoldDB; P29785; -.
DR   SMR; P29785; -.
DR   OMA; HVWDRAP; -.
DR   OrthoDB; 9772456at2; -.
DR   UniPathway; UPA00066; -.
DR   GO; GO:0008879; F:glucose-1-phosphate thymidylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008934; F:inositol monophosphate 1-phosphatase activity; IEA:TreeGrafter.
DR   GO; GO:0006020; P:inositol metabolic process; IEA:TreeGrafter.
DR   GO; GO:0007165; P:signal transduction; IEA:TreeGrafter.
DR   GO; GO:0019872; P:streptomycin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd01637; IMPase_like; 1.
DR   Gene3D; 3.40.190.80; -; 1.
DR   Gene3D; 3.30.540.10; Fructose-1,6-Bisphosphatase, subunit A, domain 1; 1.
DR   InterPro; IPR000760; Inositol_monophosphatase-like.
DR   PANTHER; PTHR20854; INOSITOL MONOPHOSPHATASE; 1.
DR   PANTHER; PTHR20854:SF4; INOSITOL-1-MONOPHOSPHATASE-RELATED; 1.
DR   Pfam; PF00459; Inositol_P; 1.
DR   PRINTS; PR00377; IMPHPHTASES.
DR   SUPFAM; SSF56655; Carbohydrate phosphatase; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Streptomycin biosynthesis; Transferase.
FT   CHAIN           1..259
FT                   /note="Glucose-1-phosphate thymidylyltransferase"
FT                   /id="PRO_0000072287"
SQ   SEQUENCE   259 AA;  27858 MW;  D2DA6E0E75AFF28A CRC64;
     MTDNDSDVRL AHRLAEIADT LAWEFFGGAP AVRHKSDGSP VSEADLAVEK ALLAVLAAER
     PGDAVLTEES GSLGTRSSRR RWILDPIDGT IPFLAGERGW GTHVALEVDE ELRTAVLSRP
     TERSRWWAVR GRGAFTSVRG EPLSAARPLR IPSAPLPLEA ARVGGFLMPD SPVEPVRDRM
     RWVESSVCLV GDLLEGRVDA VIDEGGHVWD RAPAALLVHE AGGRVDDLRG GGRLDERWLV
     YAADGVADGL AGLLRDVGA
//