ID   CSK2B_CAEEL             Reviewed;         234 AA.
AC   P28548; O62352; Q22077;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   02-SEP-2026, entry version 187.
DE   RecName: Full=Casein kinase II subunit beta;
DE            Short=CK II beta;
GN   Name=kin-10; Synonyms=kin-5; ORFNames=T01G9.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
RX   PubMed=1918084; DOI=10.1016/s0021-9258(18)55062-6;
RA   Hu E., Rubin C.S.;
RT   "Casein kinase II from Caenorhabditis elegans. Cloning, characterization,
RT   and developmental regulation of the gene encoding the beta subunit.";
RL   J. Biol. Chem. 266:19796-19802(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION, INTERACTION WITH LOV-1, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=16481400; DOI=10.1091/mbc.e05-10-0935;
RA   Hu J., Bae Y.-K., Knobel K.M., Barr M.M.;
RT   "Casein kinase II and calcineurin modulate TRPP function and ciliary
RT   localization.";
RL   Mol. Biol. Cell 17:2200-2211(2006).
CC   -!- FUNCTION: Participates in Wnt signaling. Plays a complex role in
CC       regulating the basal catalytic activity of the alpha subunit (By
CC       similarity). Modulates two aspects of male mating behavior; response to
CC       hermaphrodite contact and vulval location, acting in the same pathway
CC       as lov-1 and pkd-2. {ECO:0000250, ECO:0000269|PubMed:16481400}.
CC   -!- SUBUNIT: Tetramer of two alpha and two beta subunits. Interacts (via C-
CC       terminus) with lov-1 (via PLAT domain). {ECO:0000269|PubMed:16481400}.
CC   -!- INTERACTION:
CC       P28548; P18334: kin-3; NbExp=5; IntAct=EBI-317777, EBI-367861;
CC       P28548; Q11184: let-756; NbExp=3; IntAct=EBI-317777, EBI-3843983;
CC       P28548; Q09624: lov-1; NbExp=2; IntAct=EBI-317777, EBI-2529627;
CC   -!- SUBCELLULAR LOCATION: Cell projection, axon
CC       {ECO:0000269|PubMed:16481400}. Cell projection, cilium
CC       {ECO:0000269|PubMed:16481400}. Cell projection, dendrite
CC       {ECO:0000269|PubMed:16481400}. Perikaryon
CC       {ECO:0000269|PubMed:16481400}. Note=Enriched in cilia in male sensory
CC       neurons.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=P28548-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=P28548-2; Sequence=VSP_001093;
CC   -!- TISSUE SPECIFICITY: Expressed in a subset of the adult male sensory
CC       neurons: CEM head neurons, ray RnB neurons, and hook HOB tail neurons.
CC       {ECO:0000269|PubMed:16481400}.
CC   -!- DEVELOPMENTAL STAGE: Elevated levels are observed during embryogenesis,
CC       liver regeneration, and adipocyte differentiation.
CC   -!- PTM: Phosphorylated by alpha subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; M73827; AAA27983.1; -; Genomic_DNA.
DR   EMBL; Z75713; CAB00056.1; -; Genomic_DNA.
DR   EMBL; Z75713; CAB00053.1; -; Genomic_DNA.
DR   PIR; B87852; B87852.
DR   PIR; T24317; T24317.
DR   RefSeq; NP_001379151.1; NM_001392666.2. [P28548-2]
DR   RefSeq; NP_001379152.1; NM_001392665.1. [P28548-1]
DR   AlphaFoldDB; P28548; -.
DR   SMR; P28548; -.
DR   BioGRID; 38044; 32.
DR   FunCoup; P28548; 3094.
DR   IntAct; P28548; 15.
DR   STRING; 6239.T01G9.6b.2; -.
DR   PaxDb; 6239-T01G9.6b.2; -.
DR   PeptideAtlas; P28548; -.
DR   EnsemblMetazoa; T01G9.6a.1; T01G9.6a.1; WBGene00002196.
DR   EnsemblMetazoa; T01G9.6a.2; T01G9.6a.2; WBGene00002196.
DR   EnsemblMetazoa; T01G9.6b.1; T01G9.6b.1; WBGene00002196.
DR   EnsemblMetazoa; T01G9.6b.2; T01G9.6b.2; WBGene00002196.
DR   GeneID; 172610; -.
DR   KEGG; cel:CELE_T01G9.6; -.
DR   UCSC; T01G9.6a.1; c. elegans. [P28548-1]
DR   AGR; WB:WBGene00002196; -.
DR   CTD; 172610; -.
DR   WormBase; T01G9.6a; CE18168; WBGene00002196; kin-10. [P28548-1]
DR   WormBase; T01G9.6b; CE06343; WBGene00002196; kin-10. [P28548-2]
DR   eggNOG; KOG3092; Eukaryota.
DR   HOGENOM; CLU_034027_3_3_1; -.
DR   InParanoid; P28548; -.
DR   OMA; DADFGRC; -.
DR   OrthoDB; 3971593at2759; -.
DR   PhylomeDB; P28548; -.
DR   Reactome; R-CEL-1483191; Synthesis of PC.
DR   Reactome; R-CEL-201688; WNT mediated activation of DVL.
DR   Reactome; R-CEL-445144; Signal transduction by L1.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   Reactome; R-CEL-6804756; Regulation of TP53 Activity through Phosphorylation.
DR   Reactome; R-CEL-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR   Reactome; R-CEL-8934903; Receptor Mediated Mitophagy.
DR   Reactome; R-CEL-8948751; Regulation of PTEN stability and activity.
DR   SignaLink; P28548; -.
DR   PRO; PR:P28548; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00002196; Expressed in embryo and 4 other cell types or tissues.
DR   GO; GO:0030424; C:axon; IDA:UniProtKB.
DR   GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR   GO; GO:0030425; C:dendrite; IDA:UniProtKB.
DR   GO; GO:0043025; C:neuronal cell body; IDA:UniProtKB.
DR   GO; GO:0097730; C:non-motile cilium; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0005956; C:protein kinase CK2 complex; IDA:WormBase.
DR   GO; GO:0019887; F:protein kinase regulator activity; IEA:InterPro.
DR   GO; GO:0034606; P:response to hermaphrodite contact; IMP:UniProtKB.
DR   GO; GO:0034608; P:vulval location; IMP:UniProtKB.
DR   FunFam; 1.10.1820.10:FF:000001; Casein kinase II subunit beta; 1.
DR   FunFam; 2.20.25.20:FF:000002; Casein kinase II subunit beta; 1.
DR   Gene3D; 2.20.25.20; -; 1.
DR   Gene3D; 1.10.1820.10; protein kinase ck2 holoenzyme, chain C, domain 1; 1.
DR   InterPro; IPR016149; Casein_kin_II_reg-sub_N.
DR   InterPro; IPR035991; Casein_kinase_II_beta-like.
DR   InterPro; IPR000704; Casein_kinase_II_reg-sub.
DR   PANTHER; PTHR11740; CASEIN KINASE II SUBUNIT BETA; 1.
DR   PANTHER; PTHR11740:SF0; CASEIN KINASE II SUBUNIT BETA; 1.
DR   Pfam; PF01214; CK_II_beta; 1.
DR   PRINTS; PR00472; CASNKINASEII.
DR   SMART; SM01085; CK_II_beta; 1.
DR   SUPFAM; SSF57798; Casein kinase II beta subunit; 1.
DR   PROSITE; PS01101; CK2_BETA; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Behavior; Cell projection; Cilium; Phosphoprotein;
KW   Reference proteome; Wnt signaling pathway.
FT   CHAIN           1..234
FT                   /note="Casein kinase II subunit beta"
FT                   /id="PRO_0000068244"
FT   MOD_RES         2
FT                   /note="Phosphoserine; by autocatalysis"
FT                   /evidence="ECO:0000305"
FT   VAR_SEQ         58
FT                   /note="P -> PE (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_001093"
FT   CONFLICT        141
FT                   /note="D -> M (in Ref. 1; AAA27983)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   234 AA;  26436 MW;  634E76B78761AD74 CRC64;
     MSSSEEVSWI TWFCGLRGNE FFCEVDEEYI QDRFNLTGLN EQVPKYRQAL DMILDLEPDD
     IEDNATNTDL VEQAAEMLYG LIHARYILTN RGISQMVEKW RDHDFGVCPR VYCENQPMLP
     IGLSDVPGEA MVKLYCPRCN DVFVPRSSRH QHTDGSYFGT GFPHMLFFVH PDLRPRRPVT
     QFVPKLYGFK IHPVAYGGQE GNSGGNTANN VAAAQNNTTP AGQQSGGQFN NYGL
//