ID 5HT2A_DROME Reviewed; 834 AA. AC P28285; Q0E921; Q4QQC9; Q5MTE9; Q5MTF1; Q5MTF2; Q5MTF3; Q5MTF8; Q5MTF9; AC Q5MTG0; Q5MTG1; Q5MTG2; Q5MTG3; Q5MTG4; Q5MTG6; Q5MTG9; Q5MTH1; Q5MTH2; AC Q5MTH5; Q5MTH6; Q5MTH7; Q5MTH9; Q5MTI0; Q5MTI1; Q5MTI4; Q5MTI6; Q5MTI7; AC Q5MTI8; Q5MTJ0; Q5MTJ4; Q5MTJ5; Q5MTJ6; Q5MTJ9; Q5MTK5; Q5MTL1; Q5MTL5; AC Q5MTL6; Q5MTM2; Q5MTM5; Q5MTM8; Q5MTN6; Q5MTQ1; Q5MTQ4; Q5MTR1; Q5MTR3; AC Q5MTR6; Q5MTR8; Q5MTS1; Q5MTT8; Q5MTV6; Q5MTV7; Q5MTV9; Q5MTW8; Q5MTX2; AC Q5MTX7; Q5MTY3; Q5MTY7; Q5MTY8; Q5MTY9; Q5MTZ0; Q5MTZ6; Q5MUJ0; Q5MUK2; AC Q5MUK5; Q5MUK8; Q5MUL0; Q5MUL2; Q5MUL5; Q5MUM3; Q5MUM7; Q5MUM9; Q5MUN0; AC Q5MUN1; Q5MUN2; Q5MUP0; Q5MUP5; Q5MUP6; Q5MUP7; Q5MUP8; Q5MUQ1; Q5MUQ6; AC Q5MUQ7; Q5MUQ8; Q5MUQ9; Q5MUR1; Q5MUR2; Q5MUR3; Q5MUR4; Q5MUR5; Q5MUT3; AC Q5MUT4; Q5MUT7; Q5MUT9; Q5MUU2; Q5MUU5; Q5MUU6; Q5MUV4; Q5MUV5; Q5MUV8; AC Q5MUV9; Q5MUW3; Q5MUW4; Q5MUW7; Q5MUX4; Q5MUX6; Q5MUY1; Q5MUY3; Q5MV05; AC Q5MV06; Q5MV07; Q5MV08; Q5MV13; Q5MV14; Q5MV15; Q5MV26; Q5MV30; Q9V8Q9; DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot. DT 12-APR-2005, sequence version 2. DT 02-SEP-2026, entry version 172. DE RecName: Full=5-hydroxytryptamine receptor 2A; DE Short=5-HT receptor 2A; DE AltName: Full=Serotonin receptor 2A; GN Name=5-HT1A; Synonyms=5HT-R2A; ORFNames=CG16720; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida; OC Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota; OC Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ALA-96 AND ASN-196. RC STRAIN=Canton-S, and Oregon-R; TISSUE=Head; RX PubMed=1310937; DOI=10.1002/j.1460-2075.1992.tb05021.x; RA Saudou F., Boschert U., Amlaiky N., Plassat J.-L., Hen R.; RT "A family of Drosophila serotonin receptors with distinct intracellular RT signalling properties and expression patterns."; RL EMBO J. 11:7-17(1992). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-588. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., RA Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-588. RC STRAIN=Berkeley; TISSUE=Embryo; RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., RA Park S., Wan K.H., Yu C., Celniker S.E.; RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-242, NUCLEOTIDE SEQUENCE [GENOMIC RP DNA] OF 511-834, AND VARIANTS 29-GLU--PRO-32 DEL; GLN-46; VAL-49; GLU-51; RP GLU-52; GLY-54; THR-76; THR-86; GLN-91; ALA-96; THR-143; THR-146; VAL-171; RP ASP-182; TYR-184; ASN-196; HIS-198; GLY-213; LEU-531; ALA-536; RP 547-ALA--GLY-550 DELINS GLY-PRO-MET-GLY-PRO-LEU; VAL-571; LYS-585; MET-588; RP ARG-589; VAL-648; PRO-657; TRP-682; ILE-688; THR-692; THR-706; HIS-716; RP GLN-HIS-716 INS; 716-GLN-GLN-717 DEL; 716-GLN--GLN-718 DEL AND RP 717-GLN--GLN-719 DELINS HIS. RC STRAIN=CA-001, CA-002, CA-003, CA-008, CA-009, CA-010, CA-011, CA-012, RC CA-013, CA-015, CA-017, CA-018, CA-023, CA-026, CA-027, CA-030, RC CA-031, CA-033, CA-034, CA-035, CA-037, CA-040, CA-041, CA-043, RC CA-044, CA-045, CA-046, CA-047, CA-048, CA-052, CA-055, CA-056, RC CA-057, CA-058, CA-060, CA-061, CA-062, CA-063, CA-064, CA-065, RC CA-066, CA-068, CA-069, CA-070, CA-072, CA-073, CA-075, CA-081, RC CA-083, CA-086, CA-087, CA-088, CA-089, CA-090, CA-091, CA-093, RC CA-095, CA-096, CA-100, CA-105, CA-113, CA-114, CA-115, CA-118, RC CA-120, CA-123, CA-126, CA-127, CA-128, CA-129, CA-130, CA-132, RC CA-133, CA-136, CA-137, CA-140, CA-142, CA-144, CA-145, CA-147, RC CA-148, NC-001, NC-002, NC-003, NC-004, NC-005, NC-006, NC-008, RC NC-010, NC-011, NC-012, NC-013, NC-014, NC-015, NC-017, NC-021, RC NC-022, NC-023, NC-024, NC-025, NC-026, NC-027, NC-028, NC-029, RC NC-030, NC-032, NC-033, NC-034, NC-036, NC-037, NC-038, NC-039, RC NC-040, NC-041, NC-042, NC-043, NC-044, NC-046, NC-047, NC-048, RC NC-049, NC-050, NC-051, NC-052, NC-053, NC-054, NC-057, NC-058, RC NC-059, NC-060, NC-061, NC-064, NC-066, NC-067, NC-068, NC-069, RC NC-070, NC-071, NC-072, NC-073, NC-074, NC-075, NC-077, NC-079, RC NC-080, NC-081, NC-084, NC-086, NC-087, NC-088, NC-089, NC-091, RC NC-092, NC-094, NC-095, NC-096, NC-097, NC-098, NC-100, NC-101, RC NC-103, NC-104, NC-105, NC-107, NC-108, NC-109, NC-110, NC-111, RC NC-112, NC-113, NC-114, NC-115, NC-116, NC-118, NC-119, NC-121, RC NC-123, NC-124, NC-125, NC-126, NC-127, NC-128, NC-129, NC-131, RC NC-133, NC-134, NC-135, NC-136, NC-137, NC-138, NC-139, NC-141, RC NC-142, NC-144, NC-146, NC-147, NC-148, NC-149, and NC-150; RX PubMed=15611167; DOI=10.1534/genetics.104.028712; RA Nikoh N., Duty A., Gibson G.; RT "Effects of population structure and sex on association between serotonin RT receptors and Drosophila heart rate."; RL Genetics 168:1963-1974(2004). CC -!- FUNCTION: This is one of the several different receptors for 5- CC hydroxytryptamine (serotonin), a biogenic hormone that functions as a CC neurotransmitter, a hormone, and a mitogen. The activity of this CC receptor is mediated by G proteins which inhibit adenylate cyclase. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G protein-coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- SEQUENCE CAUTION: CC Sequence=AAY84887.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z11489; CAA77570.1; -; mRNA. DR EMBL; AE013599; AAF57603.1; -; Genomic_DNA. DR EMBL; AE013599; AAM68432.1; -; Genomic_DNA. DR EMBL; BT023487; AAY84887.1; ALT_SEQ; mRNA. DR EMBL; AY564785; AAS73796.1; -; Genomic_DNA. DR EMBL; AY564786; AAS73797.1; -; Genomic_DNA. DR EMBL; AY564787; AAS73798.1; -; Genomic_DNA. DR EMBL; AY564788; AAS73799.1; -; Genomic_DNA. DR EMBL; AY564789; AAS73800.1; -; Genomic_DNA. DR EMBL; AY564790; AAS73801.1; -; Genomic_DNA. DR EMBL; AY564791; AAS73802.1; -; Genomic_DNA. DR EMBL; AY564792; AAS73803.1; -; Genomic_DNA. DR EMBL; AY564793; AAS73804.1; -; Genomic_DNA. DR EMBL; AY564794; AAS73805.1; -; Genomic_DNA. DR EMBL; AY564795; AAS73806.1; -; Genomic_DNA. DR EMBL; AY564796; AAS73807.1; -; Genomic_DNA. DR EMBL; AY564797; AAS73808.1; -; Genomic_DNA. DR EMBL; AY564798; AAS73809.1; -; Genomic_DNA. DR EMBL; AY564799; AAS73810.1; -; Genomic_DNA. DR EMBL; AY564800; AAS73811.1; -; Genomic_DNA. DR EMBL; AY564801; AAS73812.1; -; Genomic_DNA. DR EMBL; AY564802; AAS73813.1; -; Genomic_DNA. DR EMBL; AY564803; AAS73814.1; -; Genomic_DNA. DR EMBL; AY564804; AAS73815.1; -; Genomic_DNA. DR EMBL; AY564805; AAS73816.1; -; Genomic_DNA. DR EMBL; AY564806; AAS73817.1; -; Genomic_DNA. DR EMBL; AY564807; AAS73818.1; -; Genomic_DNA. DR EMBL; AY564808; AAS73819.1; -; Genomic_DNA. DR EMBL; AY564809; AAS73820.1; -; Genomic_DNA. DR EMBL; AY564810; AAS73821.1; -; Genomic_DNA. DR EMBL; AY564811; AAS73822.1; -; Genomic_DNA. DR EMBL; AY564812; AAS73823.1; -; Genomic_DNA. DR EMBL; AY564813; AAS73824.1; -; Genomic_DNA. DR EMBL; AY564814; AAS73825.1; -; Genomic_DNA. DR EMBL; AY564815; AAS73826.1; -; Genomic_DNA. DR EMBL; AY564816; AAS73827.1; -; Genomic_DNA. DR EMBL; AY564817; AAS73828.1; -; Genomic_DNA. DR EMBL; AY564818; AAS73829.1; -; Genomic_DNA. DR EMBL; AY564819; AAS73830.1; -; Genomic_DNA. DR EMBL; AY564820; AAS73831.1; -; Genomic_DNA. DR EMBL; AY564821; AAS73832.1; -; Genomic_DNA. DR EMBL; AY564822; AAS73833.1; -; Genomic_DNA. DR EMBL; AY564823; AAS73834.1; -; Genomic_DNA. DR EMBL; AY564824; AAS73835.1; -; Genomic_DNA. DR EMBL; AY564825; AAS73836.1; -; Genomic_DNA. DR EMBL; AY564826; AAS73837.1; -; Genomic_DNA. DR EMBL; AY564827; AAS73838.1; -; Genomic_DNA. DR EMBL; AY564828; AAS73839.1; -; Genomic_DNA. DR EMBL; AY564829; AAS73840.1; -; Genomic_DNA. DR EMBL; AY564830; AAS73841.1; -; Genomic_DNA. DR EMBL; AY564831; AAS73842.1; -; Genomic_DNA. DR EMBL; AY564832; AAS73843.1; -; Genomic_DNA. DR EMBL; AY564833; AAS73844.1; -; Genomic_DNA. DR EMBL; AY564834; AAS73845.1; -; Genomic_DNA. DR EMBL; AY564835; AAS73846.1; -; Genomic_DNA. DR EMBL; AY564836; AAS73847.1; -; Genomic_DNA. DR EMBL; AY564837; AAS73848.1; -; Genomic_DNA. DR EMBL; AY564838; AAS73849.1; -; Genomic_DNA. DR EMBL; AY564839; AAS73850.1; -; Genomic_DNA. DR EMBL; AY564840; AAS73851.1; -; Genomic_DNA. DR EMBL; AY564841; AAS73852.1; -; Genomic_DNA. DR EMBL; AY564842; AAS73853.1; -; Genomic_DNA. DR EMBL; AY564843; AAS73854.1; -; Genomic_DNA. DR EMBL; AY564844; AAS73855.1; -; Genomic_DNA. DR EMBL; AY564845; AAS73856.1; -; Genomic_DNA. DR EMBL; AY564846; AAS73857.1; -; Genomic_DNA. DR EMBL; AY564847; AAS73858.1; -; Genomic_DNA. DR EMBL; AY564848; AAS73859.1; -; Genomic_DNA. DR EMBL; AY564849; AAS73860.1; -; Genomic_DNA. DR EMBL; AY564850; AAS73861.1; -; Genomic_DNA. DR EMBL; AY564851; AAS73862.1; -; Genomic_DNA. DR EMBL; AY564852; AAS73863.1; -; Genomic_DNA. DR EMBL; AY564853; AAS73864.1; -; Genomic_DNA. DR EMBL; AY564854; AAS73865.1; -; Genomic_DNA. DR EMBL; AY564855; AAS73866.1; -; Genomic_DNA. DR EMBL; AY564856; AAS73867.1; -; Genomic_DNA. DR EMBL; AY564857; AAS73868.1; -; Genomic_DNA. DR EMBL; AY564858; AAS73869.1; -; Genomic_DNA. DR EMBL; AY564859; AAS73870.1; -; Genomic_DNA. DR EMBL; AY564860; AAS73871.1; -; Genomic_DNA. DR EMBL; AY564861; AAS73872.1; -; Genomic_DNA. DR EMBL; AY564862; AAS73873.1; -; Genomic_DNA. DR EMBL; AY564863; AAS73874.1; -; Genomic_DNA. DR EMBL; AY564864; AAS73875.1; -; Genomic_DNA. DR EMBL; AY564865; AAS73876.1; -; Genomic_DNA. DR EMBL; AY564866; AAS73877.1; -; Genomic_DNA. DR EMBL; AY564867; AAS73878.1; -; Genomic_DNA. DR EMBL; AY564868; AAS73879.1; -; Genomic_DNA. DR EMBL; AY564869; AAS73880.1; -; Genomic_DNA. DR EMBL; AY564870; AAS73881.1; -; Genomic_DNA. DR EMBL; AY564871; AAS73882.1; -; Genomic_DNA. DR EMBL; AY564872; AAS73883.1; -; Genomic_DNA. DR EMBL; AY564873; AAS73884.1; -; Genomic_DNA. DR EMBL; AY564874; AAS73885.1; -; Genomic_DNA. DR EMBL; AY564875; AAS73886.1; -; Genomic_DNA. DR EMBL; AY564876; AAS73887.1; -; Genomic_DNA. DR EMBL; AY564877; AAS73888.1; -; Genomic_DNA. DR EMBL; AY564878; AAS73889.1; -; Genomic_DNA. DR EMBL; AY564879; AAS73890.1; -; Genomic_DNA. DR EMBL; AY564880; AAS73891.1; -; Genomic_DNA. DR EMBL; AY564881; AAS73892.1; -; Genomic_DNA. DR EMBL; AY564882; AAS73893.1; -; Genomic_DNA. DR EMBL; AY564883; AAS73894.1; -; Genomic_DNA. DR EMBL; AY564884; AAS73895.1; -; Genomic_DNA. DR EMBL; AY564885; AAS73896.1; -; Genomic_DNA. DR EMBL; AY564886; AAS73897.1; -; Genomic_DNA. DR EMBL; AY564887; AAS73898.1; -; Genomic_DNA. DR EMBL; AY564888; AAS73899.1; -; Genomic_DNA. DR EMBL; AY564889; AAS73900.1; -; Genomic_DNA. DR EMBL; AY564890; AAS73901.1; -; Genomic_DNA. DR EMBL; AY564891; AAS73902.1; -; Genomic_DNA. DR EMBL; AY564892; AAS73903.1; -; Genomic_DNA. DR EMBL; AY564893; AAS73904.1; -; Genomic_DNA. DR EMBL; AY564894; AAS73905.1; -; Genomic_DNA. DR EMBL; AY564895; AAS73906.1; -; Genomic_DNA. DR EMBL; AY564896; AAS73907.1; -; Genomic_DNA. DR EMBL; AY564897; AAS73908.1; -; Genomic_DNA. DR EMBL; AY564898; AAS73909.1; -; Genomic_DNA. DR EMBL; AY564899; AAS73910.1; -; Genomic_DNA. DR EMBL; AY564900; AAS73911.1; -; Genomic_DNA. DR EMBL; AY564901; AAS73912.1; -; Genomic_DNA. DR EMBL; AY564902; AAS73913.1; -; Genomic_DNA. DR EMBL; AY564903; AAS73914.1; -; Genomic_DNA. DR EMBL; AY564904; AAS73915.1; -; Genomic_DNA. DR EMBL; AY564905; AAS73916.1; -; Genomic_DNA. DR EMBL; AY564906; AAS73917.1; -; Genomic_DNA. DR EMBL; AY564907; AAS73918.1; -; Genomic_DNA. DR EMBL; AY564908; AAS73919.1; -; Genomic_DNA. DR EMBL; AY564909; AAS73920.1; -; Genomic_DNA. DR EMBL; AY564910; AAS73921.1; -; Genomic_DNA. DR EMBL; AY564911; AAS73922.1; -; Genomic_DNA. DR EMBL; AY564912; AAS73923.1; -; Genomic_DNA. DR EMBL; AY564913; AAS73924.1; -; Genomic_DNA. DR EMBL; AY564914; AAS73925.1; -; Genomic_DNA. DR EMBL; AY564915; AAS73926.1; -; Genomic_DNA. DR EMBL; AY564916; AAS73927.1; -; Genomic_DNA. DR EMBL; AY564917; AAS73928.1; -; Genomic_DNA. DR EMBL; AY564918; AAS73929.1; -; Genomic_DNA. DR EMBL; AY564919; AAS73930.1; -; Genomic_DNA. DR EMBL; AY564920; AAS73931.1; -; Genomic_DNA. DR EMBL; AY564921; AAS73932.1; -; Genomic_DNA. DR EMBL; AY564922; AAS73933.1; -; Genomic_DNA. DR EMBL; AY564925; AAS73936.1; -; Genomic_DNA. DR EMBL; AY564926; AAS73937.1; -; Genomic_DNA. DR EMBL; AY564927; AAS73938.1; -; Genomic_DNA. DR EMBL; AY564928; AAS73939.1; -; Genomic_DNA. DR EMBL; AY564929; AAS73940.1; -; Genomic_DNA. DR EMBL; AY564930; AAS73941.1; -; Genomic_DNA. DR EMBL; AY564931; AAS73942.1; -; Genomic_DNA. DR EMBL; AY564932; AAS73943.1; -; Genomic_DNA. DR EMBL; AY564933; AAS73944.1; -; Genomic_DNA. DR EMBL; AY564934; AAS73945.1; -; Genomic_DNA. DR EMBL; AY564935; AAS73946.1; -; Genomic_DNA. DR EMBL; AY564936; AAS73947.1; -; Genomic_DNA. DR EMBL; AY564937; AAS73948.1; -; Genomic_DNA. DR EMBL; AY564938; AAS73949.1; -; Genomic_DNA. DR EMBL; AY564939; AAS73950.1; -; Genomic_DNA. DR EMBL; AY564940; AAS73951.1; -; Genomic_DNA. DR EMBL; AY564941; AAS73952.1; -; Genomic_DNA. DR EMBL; AY564942; AAS73953.1; -; Genomic_DNA. DR EMBL; AY564943; AAS73954.1; -; Genomic_DNA. DR EMBL; AY564944; AAS73955.1; -; Genomic_DNA. DR EMBL; AY564945; AAS73956.1; -; Genomic_DNA. DR EMBL; AY564946; AAS73957.1; -; Genomic_DNA. DR EMBL; AY564947; AAS73958.1; -; Genomic_DNA. DR EMBL; AY564948; AAS73959.1; -; Genomic_DNA. DR EMBL; AY564949; AAS73960.1; -; Genomic_DNA. DR EMBL; AY564950; AAS73961.1; -; Genomic_DNA. DR EMBL; AY564951; AAS73962.1; -; Genomic_DNA. DR EMBL; AY564952; AAS73963.1; -; Genomic_DNA. DR EMBL; AY564953; AAS73964.1; -; Genomic_DNA. DR EMBL; AY564954; AAS73965.1; -; Genomic_DNA. DR EMBL; AY564955; AAS73966.1; -; Genomic_DNA. DR EMBL; AY564956; AAS73967.1; -; Genomic_DNA. DR EMBL; AY564958; AAS73968.1; -; Genomic_DNA. DR EMBL; AY564959; AAS73969.1; -; Genomic_DNA. DR EMBL; AY564960; AAS73970.1; -; Genomic_DNA. DR EMBL; AY564961; AAS73971.1; -; Genomic_DNA. DR EMBL; AY564962; AAS73972.1; -; Genomic_DNA. DR EMBL; AY564963; AAS73973.1; -; Genomic_DNA. DR EMBL; AY564964; AAS73974.1; -; Genomic_DNA. DR EMBL; AY564965; AAS73975.1; -; Genomic_DNA. DR EMBL; AY564966; AAS73976.1; -; Genomic_DNA. DR EMBL; AY564967; AAS73977.1; -; Genomic_DNA. DR EMBL; AY564968; AAS73978.1; -; Genomic_DNA. DR EMBL; AY564969; AAS73979.1; -; Genomic_DNA. DR EMBL; AY564971; AAS73981.1; -; Genomic_DNA. DR EMBL; AY564972; AAS73982.1; -; Genomic_DNA. DR EMBL; AY564973; AAS73983.1; -; Genomic_DNA. DR EMBL; AY564974; AAS73984.1; -; Genomic_DNA. DR EMBL; AY564975; AAS73985.1; -; Genomic_DNA. DR EMBL; AY564976; AAS73986.1; -; Genomic_DNA. DR EMBL; AY564977; AAS73987.1; -; Genomic_DNA. DR EMBL; AY565171; AAS74181.1; -; Genomic_DNA. DR EMBL; AY565172; AAS74182.1; -; Genomic_DNA. DR EMBL; AY565173; AAS74183.1; -; Genomic_DNA. DR EMBL; AY565174; AAS74184.1; -; Genomic_DNA. DR EMBL; AY565175; AAS74185.1; -; Genomic_DNA. DR EMBL; AY565176; AAS74186.1; -; Genomic_DNA. DR EMBL; AY565177; AAS74187.1; -; Genomic_DNA. DR EMBL; AY565178; AAS74188.1; -; Genomic_DNA. DR EMBL; AY565179; AAS74189.1; -; Genomic_DNA. DR EMBL; AY565180; AAS74190.1; -; Genomic_DNA. DR EMBL; AY565181; AAS74191.1; -; Genomic_DNA. DR EMBL; AY565182; AAS74192.1; -; Genomic_DNA. DR EMBL; AY565183; AAS74193.1; -; Genomic_DNA. DR EMBL; AY565184; AAS74194.1; -; Genomic_DNA. DR EMBL; AY565185; AAS74195.1; -; Genomic_DNA. DR EMBL; AY565186; AAS74196.1; -; Genomic_DNA. DR EMBL; AY565187; AAS74197.1; -; Genomic_DNA. DR EMBL; AY565188; AAS74198.1; -; Genomic_DNA. DR EMBL; AY565189; AAS74199.1; -; Genomic_DNA. DR EMBL; AY565190; AAS74200.1; -; Genomic_DNA. DR EMBL; AY565191; AAS74201.1; -; Genomic_DNA. DR EMBL; AY565192; AAS74202.1; -; Genomic_DNA. DR EMBL; AY565193; AAS74203.1; -; Genomic_DNA. DR EMBL; AY565194; AAS74204.1; -; Genomic_DNA. DR EMBL; AY565195; AAS74205.1; -; Genomic_DNA. DR EMBL; AY565196; AAS74206.1; -; Genomic_DNA. DR EMBL; AY565197; AAS74207.1; -; Genomic_DNA. DR EMBL; AY565198; AAS74208.1; -; Genomic_DNA. DR EMBL; AY565199; AAS74209.1; -; Genomic_DNA. DR EMBL; AY565200; AAS74210.1; -; Genomic_DNA. DR EMBL; AY565201; AAS74211.1; -; Genomic_DNA. DR EMBL; AY565202; AAS74212.1; -; Genomic_DNA. DR EMBL; AY565203; AAS74213.1; -; Genomic_DNA. DR EMBL; AY565204; AAS74214.1; -; Genomic_DNA. DR EMBL; AY565205; AAS74215.1; -; Genomic_DNA. DR EMBL; AY565206; AAS74216.1; -; Genomic_DNA. DR EMBL; AY565207; AAS74217.1; -; Genomic_DNA. DR EMBL; AY565208; AAS74218.1; -; Genomic_DNA. DR EMBL; AY565209; AAS74219.1; -; Genomic_DNA. DR EMBL; AY565210; AAS74220.1; -; Genomic_DNA. DR EMBL; AY565211; AAS74221.1; -; Genomic_DNA. DR EMBL; AY565212; AAS74222.1; -; Genomic_DNA. DR EMBL; AY565213; AAS74223.1; -; Genomic_DNA. DR EMBL; AY565214; AAS74224.1; -; Genomic_DNA. DR EMBL; AY565215; AAS74225.1; -; Genomic_DNA. DR EMBL; AY565216; AAS74226.1; -; Genomic_DNA. DR EMBL; AY565217; AAS74227.1; -; Genomic_DNA. DR EMBL; AY565218; AAS74228.1; -; Genomic_DNA. DR EMBL; AY565219; AAS74229.1; -; Genomic_DNA. DR EMBL; AY565220; AAS74230.1; -; Genomic_DNA. DR EMBL; AY565221; AAS74231.1; -; Genomic_DNA. DR EMBL; AY565222; AAS74232.1; -; Genomic_DNA. DR EMBL; AY565223; AAS74233.1; -; Genomic_DNA. DR EMBL; AY565224; AAS74234.1; -; Genomic_DNA. DR EMBL; AY565225; AAS74235.1; -; Genomic_DNA. DR EMBL; AY565226; AAS74236.1; -; Genomic_DNA. DR EMBL; AY565227; AAS74237.1; -; Genomic_DNA. DR EMBL; AY565228; AAS74238.1; -; Genomic_DNA. DR EMBL; AY565229; AAS74239.1; -; Genomic_DNA. DR EMBL; AY565230; AAS74240.1; -; Genomic_DNA. DR EMBL; AY565231; AAS74241.1; -; Genomic_DNA. DR EMBL; AY565232; AAS74242.1; -; Genomic_DNA. DR EMBL; AY565233; AAS74243.1; -; Genomic_DNA. DR EMBL; AY565234; AAS74244.1; -; Genomic_DNA. DR EMBL; AY565235; AAS74245.1; -; Genomic_DNA. DR EMBL; AY565236; AAS74246.1; -; Genomic_DNA. DR EMBL; AY565237; AAS74247.1; -; Genomic_DNA. DR EMBL; AY565238; AAS74248.1; -; Genomic_DNA. DR EMBL; AY565239; AAS74249.1; -; Genomic_DNA. DR EMBL; AY565240; AAS74250.1; -; Genomic_DNA. DR EMBL; AY565241; AAS74251.1; -; Genomic_DNA. DR EMBL; AY565242; AAS74252.1; -; Genomic_DNA. DR EMBL; AY565243; AAS74253.1; -; Genomic_DNA. DR EMBL; AY565244; AAS74254.1; -; Genomic_DNA. DR EMBL; AY565245; AAS74255.1; -; Genomic_DNA. DR EMBL; AY565246; AAS74256.1; -; Genomic_DNA. DR EMBL; AY565247; AAS74257.1; -; Genomic_DNA. DR EMBL; AY565248; AAS74258.1; -; Genomic_DNA. DR EMBL; AY565249; AAS74259.1; -; Genomic_DNA. DR EMBL; AY565250; AAS74260.1; -; Genomic_DNA. DR EMBL; AY565251; AAS74261.1; -; Genomic_DNA. DR EMBL; AY565252; AAS74262.1; -; Genomic_DNA. DR EMBL; AY565253; AAS74263.1; -; Genomic_DNA. DR EMBL; AY565254; AAS74264.1; -; Genomic_DNA. DR EMBL; AY565255; AAS74265.1; -; Genomic_DNA. DR EMBL; AY565256; AAS74266.1; -; Genomic_DNA. DR EMBL; AY565257; AAS74267.1; -; Genomic_DNA. DR EMBL; AY565258; AAS74268.1; -; Genomic_DNA. DR EMBL; AY565259; AAS74269.1; -; Genomic_DNA. DR EMBL; AY565260; AAS74270.1; -; Genomic_DNA. DR EMBL; AY565261; AAS74271.1; -; Genomic_DNA. DR EMBL; AY565262; AAS74272.1; -; Genomic_DNA. DR EMBL; AY565263; AAS74273.1; -; Genomic_DNA. DR EMBL; AY565264; AAS74274.1; -; Genomic_DNA. DR EMBL; AY565265; AAS74275.1; -; Genomic_DNA. DR EMBL; AY565266; AAS74276.1; -; Genomic_DNA. DR EMBL; AY565267; AAS74277.1; -; Genomic_DNA. DR EMBL; AY565268; AAS74278.1; -; Genomic_DNA. DR EMBL; AY565269; AAS74279.1; -; Genomic_DNA. DR EMBL; AY565270; AAS74280.1; -; Genomic_DNA. DR EMBL; AY565271; AAS74281.1; -; Genomic_DNA. DR EMBL; AY565272; AAS74282.1; -; Genomic_DNA. DR EMBL; AY565273; AAS74283.1; -; Genomic_DNA. DR EMBL; AY565274; AAS74284.1; -; Genomic_DNA. DR EMBL; AY565275; AAS74285.1; -; Genomic_DNA. DR EMBL; AY565276; AAS74286.1; -; Genomic_DNA. DR EMBL; AY565277; AAS74287.1; -; Genomic_DNA. DR EMBL; AY565278; AAS74288.1; -; Genomic_DNA. DR EMBL; AY565279; AAS74289.1; -; Genomic_DNA. DR EMBL; AY565280; AAS74290.1; -; Genomic_DNA. DR EMBL; AY565281; AAS74291.1; -; Genomic_DNA. DR EMBL; AY565282; AAS74292.1; -; Genomic_DNA. DR EMBL; AY565283; AAS74293.1; -; Genomic_DNA. DR EMBL; AY565284; AAS74294.1; -; Genomic_DNA. DR EMBL; AY565285; AAS74295.1; -; Genomic_DNA. DR EMBL; AY565286; AAS74296.1; -; Genomic_DNA. DR EMBL; AY565287; AAS74297.1; -; Genomic_DNA. DR EMBL; AY565288; AAS74298.1; -; Genomic_DNA. DR EMBL; AY565289; AAS74299.1; -; Genomic_DNA. DR EMBL; AY565290; AAS74300.1; -; Genomic_DNA. DR EMBL; AY565291; AAS74301.1; -; Genomic_DNA. DR EMBL; AY565292; AAS74302.1; -; Genomic_DNA. DR EMBL; AY565293; AAS74303.1; -; Genomic_DNA. DR EMBL; AY565294; AAS74304.1; -; Genomic_DNA. DR EMBL; AY565295; AAS74305.1; -; Genomic_DNA. DR EMBL; AY565296; AAS74306.1; -; Genomic_DNA. DR EMBL; AY565297; AAS74307.1; -; Genomic_DNA. DR EMBL; AY565298; AAS74308.1; -; Genomic_DNA. DR EMBL; AY565299; AAS74309.1; -; Genomic_DNA. DR EMBL; AY565300; AAS74310.1; -; Genomic_DNA. DR EMBL; AY565301; AAS74311.1; -; Genomic_DNA. DR EMBL; AY565302; AAS74312.1; -; Genomic_DNA. DR EMBL; AY565303; AAS74313.1; -; Genomic_DNA. DR EMBL; AY565304; AAS74314.1; -; Genomic_DNA. DR EMBL; AY565305; AAS74315.1; -; Genomic_DNA. DR EMBL; AY565306; AAS74316.1; -; Genomic_DNA. DR EMBL; AY565307; AAS74317.1; -; Genomic_DNA. DR EMBL; AY565308; AAS74318.1; -; Genomic_DNA. DR EMBL; AY565309; AAS74319.1; -; Genomic_DNA. DR EMBL; AY565310; AAS74320.1; -; Genomic_DNA. DR EMBL; AY565311; AAS74321.1; -; Genomic_DNA. DR EMBL; AY565312; AAS74322.1; -; Genomic_DNA. DR EMBL; AY565313; AAS74323.1; -; Genomic_DNA. DR EMBL; AY565314; AAS74324.1; -; Genomic_DNA. DR EMBL; AY565315; AAS74325.1; -; Genomic_DNA. DR EMBL; AY565316; AAS74326.1; -; Genomic_DNA. DR EMBL; AY565317; AAS74327.1; -; Genomic_DNA. DR EMBL; AY565318; AAS74328.1; -; Genomic_DNA. DR EMBL; AY565319; AAS74329.1; -; Genomic_DNA. DR EMBL; AY565320; AAS74330.1; -; Genomic_DNA. DR EMBL; AY565321; AAS74331.1; -; Genomic_DNA. DR EMBL; AY565322; AAS74332.1; -; Genomic_DNA. DR EMBL; AY565323; AAS74333.1; -; Genomic_DNA. DR EMBL; AY565324; AAS74334.1; -; Genomic_DNA. DR EMBL; AY565325; AAS74335.1; -; Genomic_DNA. DR EMBL; AY565326; AAS74336.1; -; Genomic_DNA. DR EMBL; AY565327; AAS74337.1; -; Genomic_DNA. DR EMBL; AY565328; AAS74338.1; -; Genomic_DNA. DR EMBL; AY565329; AAS74339.1; -; Genomic_DNA. DR EMBL; AY565330; AAS74340.1; -; Genomic_DNA. DR EMBL; AY565331; AAS74341.1; -; Genomic_DNA. DR EMBL; AY565332; AAS74342.1; -; Genomic_DNA. DR EMBL; AY565333; AAS74343.1; -; Genomic_DNA. DR EMBL; AY565334; AAS74344.1; -; Genomic_DNA. DR EMBL; AY565335; AAS74345.1; -; Genomic_DNA. DR EMBL; AY565336; AAS74346.1; -; Genomic_DNA. DR EMBL; AY565337; AAS74347.1; -; Genomic_DNA. DR EMBL; AY565338; AAS74348.1; -; Genomic_DNA. DR EMBL; AY565339; AAS74349.1; -; Genomic_DNA. DR EMBL; AY565340; AAS74350.1; -; Genomic_DNA. DR EMBL; AY565341; AAS74351.1; -; Genomic_DNA. DR EMBL; AY565342; AAS74352.1; -; Genomic_DNA. DR EMBL; AY565343; AAS74353.1; -; Genomic_DNA. DR EMBL; AY565344; AAS74354.1; -; Genomic_DNA. DR EMBL; AY565345; AAS74355.1; -; Genomic_DNA. DR EMBL; AY565346; AAS74356.1; -; Genomic_DNA. DR EMBL; AY565347; AAS74357.1; -; Genomic_DNA. DR EMBL; AY565348; AAS74358.1; -; Genomic_DNA. DR EMBL; AY565349; AAS74359.1; -; Genomic_DNA. DR EMBL; AY565350; AAS74360.1; -; Genomic_DNA. DR EMBL; AY565351; AAS74361.1; -; Genomic_DNA. DR EMBL; AY565352; AAS74362.1; -; Genomic_DNA. DR EMBL; AY565353; AAS74363.1; -; Genomic_DNA. DR EMBL; AY565354; AAS74364.1; -; Genomic_DNA. DR EMBL; AY565355; AAS74365.1; -; Genomic_DNA. DR EMBL; AY565356; AAS74366.1; -; Genomic_DNA. DR EMBL; AY565357; AAS74367.1; -; Genomic_DNA. DR EMBL; AY565358; AAS74368.1; -; Genomic_DNA. DR EMBL; AY565359; AAS74369.1; -; Genomic_DNA. DR EMBL; AY565360; AAS74370.1; -; Genomic_DNA. DR EMBL; AY565361; AAS74371.1; -; Genomic_DNA. DR EMBL; AY565362; AAS74372.1; -; Genomic_DNA. DR EMBL; AY565363; AAS74373.1; -; Genomic_DNA. DR EMBL; AY565364; AAS74374.1; -; Genomic_DNA. DR EMBL; AY565365; AAS74375.1; -; Genomic_DNA. DR EMBL; AY565366; AAS74376.1; -; Genomic_DNA. DR EMBL; AY565367; AAS74377.1; -; Genomic_DNA. DR EMBL; AY565368; AAS74378.1; -; Genomic_DNA. DR PIR; S19155; S19155. DR RefSeq; NP_725849.1; NM_166322.2. DR AlphaFoldDB; P28285; -. DR SMR; P28285; -. DR FunCoup; P28285; 188. DR STRING; 7227.FBpp0423127; -. DR GlyCosmos; P28285; 8 sites, No reported glycans. DR GlyGen; P28285; 9 sites. DR PaxDb; 7227-FBpp0423127; -. DR PeptideAtlas; P28285; -. DR EnsemblMetazoa; FBtr0086577; FBpp0085761; FBgn0004168. DR GeneID; 37196; -. DR KEGG; dme:Dmel_CG16720; -. DR AGR; FB:FBgn0004168; -. DR CTD; 37196; -. DR FlyBase; FBgn0004168; 5-HT1A. DR VEuPathDB; VectorBase:FBgn0004168; -. DR eggNOG; KOG3656; Eukaryota. DR HOGENOM; CLU_009579_11_1_1; -. DR InParanoid; P28285; -. DR OrthoDB; 10034726at2759; -. DR PhylomeDB; P28285; -. DR Reactome; R-DME-390666; Serotonin receptors. DR BioGRID-ORCS; 37196; 0 hits in 3 CRISPR screens. DR GenomeRNAi; 37196; -. DR PRO; PR:P28285; -. DR Proteomes; UP000000803; Chromosome 2R. DR Bgee; FBgn0004168; Expressed in medullary tangential neuron Mt1 (Drosophila) in brain and 107 other cell types or tissues. DR ExpressionAtlas; P28285; baseline and differential. DR GO; GO:0030425; C:dendrite; IBA:GO_Central. DR GO; GO:0016020; C:membrane; ISS:FlyBase. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0045202; C:synapse; IEA:GOC. DR GO; GO:0008227; F:G protein-coupled amine receptor activity; ISS:FlyBase. DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IDA:FlyBase. DR GO; GO:0001586; F:Gi/o-coupled serotonin receptor activity; NAS:FlyBase. DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central. DR GO; GO:0007198; P:adenylate cyclase-inhibiting serotonin receptor signaling pathway; IDA:FlyBase. DR GO; GO:0007615; P:anesthesia-resistant memory; IDA:FlyBase. DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central. DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central. DR GO; GO:0002121; P:inter-male aggressive behavior; IMP:FlyBase. DR GO; GO:0008049; P:male courtship behavior; IMP:FlyBase. DR GO; GO:0007208; P:phospholipase C-activating serotonin receptor signaling pathway; IDA:FlyBase. DR GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IMP:FlyBase. DR GO; GO:0007210; P:serotonin receptor signaling pathway; IDA:FlyBase. DR CDD; cd15331; 7tmA_5-HT1A_invertebrates; 1. DR FunFam; 1.20.1070.10:FF:000299; 5-hydroxytryptamine receptor 2B; 1. DR FunFam; 1.20.1070.10:FF:000310; 5-hydroxytryptamine receptor 2B; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR24248:SF200; 5-HYDROXYTRYPTAMINE RECEPTOR 1B-LIKE ISOFORM X1; 1. DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM01381; 7TM_GPCR_Srsx; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G protein-coupled receptor; Glycoprotein; KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..834 FT /note="5-hydroxytryptamine receptor 2A" FT /id="PRO_0000068962" FT TOPO_DOM 1..230 FT /note="Extracellular" FT /evidence="ECO:0000250" FT TRANSMEM 231..253 FT /note="Helical; Name=1" FT /evidence="ECO:0000250" FT TOPO_DOM 254..263 FT /note="Cytoplasmic" FT /evidence="ECO:0000250" FT TRANSMEM 264..285 FT /note="Helical; Name=2" FT /evidence="ECO:0000250" FT TOPO_DOM 286..300 FT /note="Extracellular" FT /evidence="ECO:0000250" FT TRANSMEM 301..322 FT /note="Helical; Name=3" FT /evidence="ECO:0000250" FT TOPO_DOM 323..341 FT /note="Cytoplasmic" FT /evidence="ECO:0000250" FT TRANSMEM 342..364 FT /note="Helical; Name=4" FT /evidence="ECO:0000250" FT TOPO_DOM 365..391 FT /note="Extracellular" FT /evidence="ECO:0000250" FT TRANSMEM 392..413 FT /note="Helical; Name=5" FT /evidence="ECO:0000250" FT TOPO_DOM 414..752 FT /note="Cytoplasmic" FT /evidence="ECO:0000250" FT TRANSMEM 753..776 FT /note="Helical; Name=6" FT /evidence="ECO:0000250" FT TOPO_DOM 777..785 FT /note="Extracellular" FT /evidence="ECO:0000250" FT TRANSMEM 786..808 FT /note="Helical; Name=7" FT /evidence="ECO:0000250" FT TOPO_DOM 809..834 FT /note="Cytoplasmic" FT /evidence="ECO:0000250" FT REGION 56..75 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 420..442 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 460..516 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 531..599 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 617..640 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 674..743 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 482..502 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 532..542 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 551..564 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 565..575 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 582..593 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 674..694 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 702..723 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 68 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 97 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 161 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 175 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 183 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 194 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 203 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 209 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 299..378 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 29..32 FT /note="Missing (in strain: CA-128)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 46 FT /note="E -> Q (in strain: NC-066)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 49 FT /note="E -> V (in strain: NC-036 and NC-123)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 51 FT /note="D -> E (in strain: CA-002, CA-008, CA-009, CA-011, FT CA-013, CA-015, CA-026, CA-031, CA-033, CA-034, CA-035, FT CA-037, CA-040, CA-048, CA-052, CA-055, CA-057, CA-060, FT CA-061, CA-063, CA-064, CA-065, CA-069, CA-072, CA-073, FT CA-075, CA-088, CA-090, CA-093, CA-096, CA-100, CA-114, FT CA-120, CA-127, CA-129, CA-132, CA-133, CA-140, CA-142, FT CA-145, CA-147, NC-003, NC-006, NC-010, NC-011, NC-014, FT NC-015, NC-021, NC-033, NC-034, NC-036, NC-040, NC-042, FT NC-044, NC-046, NC-047, NC-051, NC-052, NC-054, NC-057, FT NC-066, NC-069, NC-071, NC-073, NC-081, NC-084, NC-086, FT NC-089, NC-092, NC-094, NC-096, NC-097, NC-101, NC-103, FT NC-104, NC-107, NC-108, NC-118, NC-119, NC-121, NC-123, FT NC-127, NC-128, NC-129, NC-134, NC-136, NC-137, NC-138, FT NC-141, NC-144 and NC-148)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 52 FT /note="D -> E (in strain: NC-103 and NC-118)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 54 FT /note="A -> G (in strain: NC-061)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 76 FT /note="S -> T (in strain: NC-012, NC-023, NC-037, NC-038, FT NC-039, NC-124 and NC-131)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 86 FT /note="S -> T (in strain: CA-008, CA-009, CA-013, CA-026, FT CA-031, CA-033, CA-035, CA-037, CA-040, CA-048, CA-052, FT CA-057, CA-060, CA-061, CA-063, CA-065, CA-072, CA-073, FT CA-088, CA-093, CA-096, CA-100, CA-114, CA-120, CA-129, FT CA-132, CA-133, CA-140, CA-147, NC-011, NC-015, NC-021, FT NC-033, NC-034, NC-040, NC-042, NC-044, NC-046, NC-047, FT NC-051, NC-052, NC-054, NC-057, NC-069, NC-084, NC-089, FT NC-092, NC-094, NC-097, NC-103, NC-107, NC-119, NC-121, FT NC-127, NC-128, NC-129, NC-134, NC-137, NC-138, NC-141, FT NC-144 and NC-148)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 91 FT /note="P -> Q (in strain: CA-030, CA-068, CA-091, NC-008, FT NC-025, NC-043, NC-048, NC-060, NC-075, NC-088, NC-091, FT NC-114, NC-116 and NC-135)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 96 FT /note="V -> A (in strain: CA-008, CA-009, CA-011, CA-013, FT CA-015, CA-026, CA-031, CA-033, CA-034, CA-035, CA-037, FT CA-040, CA-048, CA-052, CA-055, CA-057, CA-060, CA-061, FT CA-063, CA-064, CA-065, CA-069, CA-072, CA-073, CA-075, FT CA-088, CA-090, CA-093, CA-095, CA-096, CA-100, CA-114, FT CA-120, CA-129, CA-132, CA-133, CA-140, CA-147, NC-010, FT NC-011, NC-012, NC-014, NC-015, NC-021, NC-023, NC-033, FT NC-034, NC-036, NC-037, NC-038, NC-039, NC-040, NC-042, FT NC-044, NC-046, NC-047, NC-051, NC-052, NC-054, NC-057, FT NC-066, NC-069, NC-073, NC-081, NC-084, NC-086, NC-089, FT NC-092, NC-094, NC-096, NC-097, NC-101, NC-103, NC-104, FT NC-107, NC-108, NC-118, NC-119, NC-121, NC-123, NC-124, FT NC-127, NC-128, NC-129, NC-131, NC-134, NC-136, NC-137, FT NC-138, NC-141, NC-144, NC-148 and Oregon-R)" FT /evidence="ECO:0000269|PubMed:1310937, FT ECO:0000269|PubMed:15611167" FT VARIANT 143 FT /note="A -> T (in strain: CA-064)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 146 FT /note="S -> T (in strain: CA-008, CA-026, CA-033, CA-035, FT CA-037, CA-048, CA-052, CA-057, CA-060, CA-063, CA-065, FT CA-072, CA-088, CA-090, CA-096, CA-100, CA-114, CA-120, FT CA-132, CA-140, CA-147, NC-011, NC-014, NC-033, NC-034, FT NC-040, NC-042, NC-044, NC-046, NC-047, NC-051, NC-052, FT NC-054, NC-057, NC-069, NC-084, NC-092, NC-094, NC-096, FT NC-103, NC-105, NC-107, NC-108, NC-118, NC-119, NC-121, FT NC-125, NC-126, NC-127, NC-129, NC-138, NC-144 and NC-148)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 171 FT /note="A -> V (in strain: CA-008, CA-009, CA-026, CA-031, FT CA-033, CA-035, CA-037, CA-048, CA-052, CA-057, CA-060, FT CA-061, CA-063, CA-065, CA-072, CA-088, CA-096, CA-100, FT CA-114, CA-120, CA-132, CA-140, CA-147, NC-011, NC-034, FT NC-040, NC-042, NC-044, NC-046, NC-047, NC-051, NC-052, FT NC-054, NC-057, NC-069, NC-084, NC-092, NC-094, NC-103, FT NC-107, NC-119, NC-121, NC-127, NC-129, NC-138, NC-144 and FT NC-148)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 182 FT /note="G -> D (in strain: NC-066)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 184 FT /note="D -> Y (in strain: NC-086, NC-104 and NC-010)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 196 FT /note="S -> N (in strain: NC-114)" FT /evidence="ECO:0000269|PubMed:1310937, FT ECO:0000269|PubMed:15611167" FT VARIANT 198 FT /note="Q -> H (in strain: CA-001, CA-009, CA-011, CA-013, FT CA-015, CA-026, CA-030, CA-031, CA-033, CA-034, CA-035, FT CA-037, CA-040, CA-046, CA-048, CA-052, CA-055, CA-057, FT CA-060, CA-061, CA-063, CA-065, CA-066, CA-068, CA-069, FT CA-072, CA-073, CA-075, CA-088, CA-090, CA-091, CA-093, FT CA-095, CA-096, CA-100, CA-114, CA-120, CA-132, CA-133, FT CA-140, CA-147, NC-008, NC-011, NC-014, NC-015, NC-025, FT NC-034, NC-040, NC-042, NC-043, NC-044, NC-046, NC-047, FT NC-048, NC-051, NC-052, NC-054, NC-057, NC-060, NC-066, FT NC-069, NC-073, NC-075, NC-081, NC-084, NC-088, NC-091, FT NC-092, NC-094, NC-096, NC-101, NC-103, NC-107, NC-108, FT NC-110, NC-113, NC-114, NC-115, NC-116, NC-118, NC-119, FT NC-121, NC-123, NC-127, NC-128, NC-129, NC-135, NC-136, FT NC-137, NC-138, NC-139, NC-142, NC-144, NC-146, NC-148 and FT Oregon-R)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 213 FT /note="S -> G (in strain: CA-015)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 531 FT /note="Q -> L (in strain: NC-104)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 536 FT /note="T -> A (in strain: CA-011, CA-017, CA-018, CA-062, FT CA-130, NC-118, NC-022, NC-026, NC-049 and NC-073)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 547..550 FT /note="APSG -> GPMGPL (in strain: CA-013, CA-026 and FT CA-093)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 571 FT /note="E -> V (in strain: CA-002, CA-003, CA-008, CA-011, FT CA-012, CA-015, CA-023, CA-027, CA-030, CA-031, CA-034, FT CA-035, CA-037, CA-043, CA-044, CA-045, CA-046, CA-048, FT CA-052, CA-055, CA-057, CA-058, CA-063, CA-064, CA-065, FT CA-066, CA-068, CA-070, CA-072, CA-073, CA-075, CA-081, FT CA-083, CA-087, CA-088, CA-089, CA-091, CA-096, CA-100, FT CA-105, CA-114, CA-120, CA-123, CA-128, CA-129, CA-133, FT CA-140, CA-145, CA-147, CA-148, NC-001, NC-002, NC-003, FT NC-010, NC-011, NC-012, NC-013, NC-015, NC-023, NC-024, FT NC-025, NC-027, NC-028, NC-029, NC-030, NC-032, NC-033, FT NC-034, NC-036, NC-040, NC-041, NC-042, NC-043, NC-044, FT NC-046, NC-047, NC-048, NC-050, NC-051, NC-052, NC-054, FT NC-057, NC-059, NC-060, NC-061, NC-066, NC-069, NC-071, FT NC-072, NC-074, NC-075, NC-077, NC-079, NC-080, NC-081, FT NC-084, NC-086, NC-087, NC-088, NC-089, NC-091, NC-092, FT NC-094, NC-098, NC-101, NC-103, NC-104, NC-107, NC-109, FT NC-110, NC-111, NC-112, NC-113, NC-114, NC-115, NC-116, FT NC-119, NC-121, NC-124, NC-127, NC-128, NC-129, NC-131, FT NC-133, NC-134, NC-135, NC-136, NC-137, NC-138, NC-144, FT NC-146, NC-147, NC-148 and NC-149)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 585 FT /note="T -> K (in strain: NC-026)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 588 FT /note="T -> M (in strain: Berkeley, CA-009, CA-010, CA-013, FT CA-026, CA-041, CA-060, CA-063, CA-066, CA-086, CA-093, FT CA-113, CA-137, CA-145, NC-006, NC-008, NC-021, NC-064, FT NC-067, NC-123, NC-142 and NC-150)" FT /evidence="ECO:0000269|PubMed:10731132, FT ECO:0000269|PubMed:15611167, ECO:0000269|Ref.4" FT VARIANT 589 FT /note="T -> R (in strain: CA-040, CA-056, CA-115, CA-118, FT CA-126, CA-132, CA-142, NC-005, NC-037, NC-038, NC-039, FT NC-053, NC-068, NC-095, NC-100, NC-105, NC-125, NC-126 and FT NC-139)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 648 FT /note="A -> V (in strain: CA-023, CA-048, NC-015, NC-110, FT NC-128, NC-133 and NC-137)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 657 FT /note="Q -> P (in strain: CA-130)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 682 FT /note="S -> W (in strain: CA-043, CA-058 and CA-105)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 688 FT /note="T -> I (in strain: CA-088)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 692 FT /note="S -> T (in strain: NC-104)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 706 FT /note="P -> T (in strain: NC-001)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 716..718 FT /note="Missing (in strain: NC-118)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 716..717 FT /note="Missing (in strain: CA-002, CA-009, CA-010, CA-011, FT CA-017, CA-018, CA-023, CA-030, CA-031, CA-037, CA-040, FT CA-041, CA-044, CA-045, CA-047, CA-048, CA-052, CA-056, FT CA-057, CA-062, CA-068, CA-070, CA-075, CA-086, CA-087, FT CA-088, CA-089, CA-091, CA-095, CA-096, CA-100, CA-113, FT CA-114, CA-115, CA-118, CA-120, CA-126, CA-127, CA-129, FT CA-132, CA-133, CA-136, CA-140, CA-142, CA-145, CA-147, FT NC-001, NC-003, NC-004, NC-005, NC-011, NC-015, NC-017, FT NC-021, NC-022, NC-025, NC-033, NC-034, NC-036, NC-037, FT NC-038, NC-039, NC-040, NC-042, NC-044, NC-046, NC-048, FT NC-049, NC-051, NC-052, NC-053, NC-054, NC-057, NC-059, FT NC-068, NC-069, NC-070, NC-071, NC-079, NC-080, NC-084, FT NC-086, NC-087, NC-088, NC-089, NC-091, NC-092, NC-094, FT NC-095, NC-100, NC-101, NC-104, NC-105, NC-107, NC-109, FT NC-110, NC-111, NC-112, NC-113, NC-114, NC-115, NC-116, FT NC-119, NC-121, NC-123, NC-125, NC-126, NC-128, NC-129, FT NC-133, NC-134, NC-135, NC-136, NC-137, NC-138, NC-139, FT NC-142, NC-144, NC-146, NC-147, NC-148, NC-149 and NC-150)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 716 FT /note="Q -> H (in strain: NC-032)" FT /evidence="ECO:0000269|PubMed:15611167" FT VARIANT 716 FT /note="Q -> QH (in strain: NC-047)" FT VARIANT 717..719 FT /note="QQQ -> H (in strain: CA-069, NC-096 and NC-108)" FT /evidence="ECO:0000269|PubMed:15611167" FT CONFLICT 135 FT /note="R -> W (in Ref. 1; CAA77570)" FT /evidence="ECO:0000305" FT CONFLICT 400 FT /note="L -> M (in Ref. 1; CAA77570)" FT /evidence="ECO:0000305" FT CONFLICT 813 FT /note="R -> Q (in Ref. 4; AAY84887)" FT /evidence="ECO:0000305" SQ SEQUENCE 834 AA; 89521 MW; D3E27389921BD04F CRC64; MAHETSFNDA LDYIYIANSM NDRAFLIAEP HPEQPNVDGQ DQDDAELEEL DDMAVTDDGQ LEDTNNNNNS KRYYSSGKRR ADFIGSLALK PPPTDVNTTT TTAGSPLATA ALAAAAASAS VAAAAARITA KAAHRALTTK QDATSSPASS PALQLIDMDN NYTNVAVGLG AMLLNDTLLL EGNDSSLFGE MLANRSGQLD LINGTGGLNV TTSKVAEDDF TQLLRMAVTS VLLGLMILVT IIGNVFVIAA IILERNLQNV ANYLVASLAV ADLFVACLVM PLGAVYEISQ GWILGPELCD IWTSCDVLCC TASILHLVAI AVDRYWAVTN IDYIHSRTSN RVFMMIFCVW TAAVIVSLAP QFGWKDPDYL QRIEQQKCMV SQDVSYQVFA TCCTFYVPLL VILALYWKIY QTARKRIHRR RPRPVDAAVN NNQPDGGAAT DTKLHRLRLR LGRFSTAKSK TGSAVGVSGP ASGGRALGLV DGNSTNTVNT VEDTEFSSSN VDSKSRAGVE APSTSGNQIA TVSHLVALAK QQGKSTAKSS AAVNGMAPSG RQEDDGQRPE HGEQEDREEL EDQDEQVGPQ PTTATSATTA AGTNESEDQC KANGVEVLED PQLQQQLEQV QQLQKSVKSG GGGGASTSNA TTITSISALS PQTPTSQGVG IAAAAAGPMT AKTSTLTSCN QSHPLCGTAN ESPSTPEPRS RQPTTPQQQP HQQAHQQQQQ QQQLSSIANP MQKVNKRKET LEAKRERKAA KTLAIITGAF VVCWLPFFVM ALTMPLCAAC QISDSVASLF LWLGYFNSTL NPVIYTIFSP EFRQAFKRIL FGGHRPVHYR SGKL //