ID   ASPX_HUMAN              Reviewed;         265 AA.
AC   P26436; Q53FF4;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   04-NOV-2026, entry version 188.
DE   RecName: Full=Acrosomal protein SP-10;
DE   AltName: Full=Acrosomal vesicle protein 1;
DE   Flags: Precursor;
GN   Name=ACRV1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=1693291; DOI=10.1095/biolreprod42.4.693;
RA   Wright R.M., John E., Klotz K., Flickinger C.J., Herr J.C.;
RT   "Cloning and sequencing of cDNAs coding for the human intra-acrosomal
RT   antigen SP-10.";
RL   Biol. Reprod. 42:693-701(1990).
RN   [2]
RP   ERRATUM OF PUBMED:1693291, AND SEQUENCE REVISION.
RA   Wright R.M., John E., Klotz K., Flickinger C.J., Herr J.C.;
RL   Biol. Reprod. 43:903-903(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ARG-126.
RX   PubMed=8373955; DOI=10.1095/biolreprod49.2.316;
RA   Wright R.M., Suri A.K., Kornreich B., Flickinger C.J., Herr J.C.;
RT   "Cloning and characterization of the gene coding for the human acrosomal
RT   protein SP-10.";
RL   Biol. Reprod. 49:316-325(1993).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-126.
RC   TISSUE=Testis;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   ALTERNATIVE SPLICING.
RC   TISSUE=Testis;
RX   PubMed=7619499; DOI=10.1002/mrd.1080410115;
RA   Freemerman A.J., Flickinger C.J., Herr J.C.;
RT   "Characterization of alternatively spliced human SP-10 mRNAs.";
RL   Mol. Reprod. Dev. 41:100-108(1995).
RN   [7]
RP   PROTEIN SEQUENCE OF 78-100; 106-122 AND 127-151.
RX   PubMed=1637938; DOI=10.1095/biolreprod47.1.11;
RA   Herr J.C., Klotz K., Shannon J., Wright R.M., Flickinger C.J.;
RT   "Purification and microsequencing of the intra-acrosomal protein SP-10.
RT   Evidence that SP-10 heterogeneity results from endoproteolytic processes.";
RL   Biol. Reprod. 47:11-20(1992).
CC   -!- INTERACTION:
CC       P26436; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-25884472, EBI-1045797;
CC       P26436; Q9BZ23-2: PANK2; NbExp=3; IntAct=EBI-25884472, EBI-25929070;
CC       P26436; P50897: PPT1; NbExp=3; IntAct=EBI-25884472, EBI-1237011;
CC       P26436; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-25884472, EBI-5235340;
CC       P26436; Q86WV8: TSC1; NbExp=3; IntAct=EBI-25884472, EBI-12806590;
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome.
CC       Note=Nascent acrosomal vesicle of Golgi phase spermatids.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=11;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=1;
CC         IsoId=P26436-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P26436-2; Sequence=VSP_004127;
CC       Name=3;
CC         IsoId=P26436-3; Sequence=VSP_004120;
CC       Name=4;
CC         IsoId=P26436-4; Sequence=VSP_004121;
CC       Name=5;
CC         IsoId=P26436-5; Sequence=VSP_004121, VSP_004127;
CC       Name=6;
CC         IsoId=P26436-6; Sequence=VSP_004122;
CC       Name=7;
CC         IsoId=P26436-7; Sequence=VSP_004120, VSP_004125;
CC       Name=8;
CC         IsoId=P26436-8; Sequence=VSP_004121, VSP_004128;
CC       Name=9;
CC         IsoId=P26436-9; Sequence=VSP_004121, VSP_004126;
CC       Name=10;
CC         IsoId=P26436-10; Sequence=VSP_004123;
CC       Name=11;
CC         IsoId=P26436-11; Sequence=VSP_004124;
CC   -!- TISSUE SPECIFICITY: Testis.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M82967; AAA36625.1; -; mRNA.
DR   EMBL; M82968; AAA36626.1; -; mRNA.
DR   EMBL; S65583; AAB28238.2; -; Genomic_DNA.
DR   EMBL; S65606; AAB28238.2; JOINED; Genomic_DNA.
DR   EMBL; S65576; AAB28238.2; JOINED; Genomic_DNA.
DR   EMBL; S65578; AAB28238.2; JOINED; Genomic_DNA.
DR   EMBL; AK223335; BAD97055.1; -; mRNA.
DR   EMBL; BC014588; AAH14588.1; -; mRNA.
DR   CCDS; CCDS44759.1; -. [P26436-2]
DR   CCDS; CCDS44761.1; -. [P26436-4]
DR   CCDS; CCDS8460.1; -. [P26436-1]
DR   CCDS; CCDS8461.1; -. [P26436-3]
DR   PIR; A37225; A37225.
DR   PIR; B37225; B37225.
DR   RefSeq; NP_001603.1; NM_001612.6. [P26436-1]
DR   RefSeq; NP_064454.1; NM_020069.5. [P26436-2]
DR   RefSeq; NP_064492.1; NM_020107.5. [P26436-3]
DR   RefSeq; NP_064493.1; NM_020108.5. [P26436-4]
DR   AlphaFoldDB; P26436; -.
DR   BioGRID; 106572; 3.
DR   FunCoup; P26436; 6.
DR   IntAct; P26436; 7.
DR   STRING; 9606.ENSP00000432816; -.
DR   GlyCosmos; P26436; 1 site, No reported glycans.
DR   GlyGen; P26436; 1 site.
DR   BioMuta; ACRV1; -.
DR   DMDM; 1351991; -.
DR   MassIVE; P26436; -.
DR   PaxDb; 9606-ENSP00000432816; -.
DR   PeptideAtlas; P26436; -.
DR   ProteomicsDB; 54335; -. [P26436-1]
DR   ProteomicsDB; 54336; -. [P26436-10]
DR   ProteomicsDB; 54337; -. [P26436-11]
DR   ProteomicsDB; 54338; -. [P26436-2]
DR   ProteomicsDB; 54339; -. [P26436-3]
DR   ProteomicsDB; 54340; -. [P26436-4]
DR   ProteomicsDB; 54341; -. [P26436-5]
DR   ProteomicsDB; 54342; -. [P26436-6]
DR   ProteomicsDB; 54343; -. [P26436-7]
DR   ProteomicsDB; 54344; -. [P26436-8]
DR   ProteomicsDB; 54345; -. [P26436-9]
DR   Antibodypedia; 32960; 249 antibodies from 29 providers.
DR   DNASU; 56; -.
DR   Ensembl; ENST00000315608.7; ENSP00000317684.3; ENSG00000134940.14. [P26436-2]
DR   Ensembl; ENST00000527795.1; ENSP00000436819.1; ENSG00000134940.14. [P26436-4]
DR   Ensembl; ENST00000530048.5; ENSP00000433720.1; ENSG00000134940.14. [P26436-3]
DR   Ensembl; ENST00000533904.6; ENSP00000432816.1; ENSG00000134940.14. [P26436-1]
DR   GeneID; 56; -.
DR   KEGG; hsa:56; -.
DR   MANE-Select; ENST00000533904.6; ENSP00000432816.1; NM_001612.6; NP_001603.1.
DR   UCSC; uc001qcl.4; human. [P26436-1]
DR   AGR; HGNC:127; -.
DR   ClinPGx; PA24454; -.
DR   CTD; 56; -.
DR   DisGeNET; 56; -.
DR   GeneCards; ACRV1; -.
DR   HGNC; HGNC:127; ACRV1.
DR   HPA; ENSG00000134940; Tissue enriched (testis).
DR   MalaCards; ACRV1; -.
DR   MIM; 102525; gene.
DR   OpenTargets; ENSG00000134940; -.
DR   VEuPathDB; HostDB:ENSG00000134940; -.
DR   eggNOG; ENOG502QRB1; Eukaryota.
DR   GeneTree; ENSGT00940000162351; -.
DR   HOGENOM; CLU_070242_0_0_1; -.
DR   InParanoid; P26436; -.
DR   OMA; ACAYMND; -.
DR   OrthoDB; 4779276at2759; -.
DR   PAN-GO; P26436; 2 GO annotations based on evolutionary models.
DR   PhylomeDB; P26436; -.
DR   PathwayCommons; P26436; -.
DR   SignaLink; P26436; -.
DR   Agora; ENSG00000134940; -.
DR   BioGRID-ORCS; 56; 14 hits in 1134 CRISPR screens.
DR   GeneWiki; ACRV1; -.
DR   GenomeRNAi; 56; -.
DR   Pharos; P26436; Tbio.
DR   PRO; PR:P26436; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; P26436; protein.
DR   Bgee; ENSG00000134940; Expressed in left testis and 104 other cell types or tissues.
DR   GO; GO:0001669; C:acrosomal vesicle; IDA:HPA.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; NAS:UniProtKB.
DR   CDD; cd23628; TFP_LU_ECD_SP10_like; 1.
DR   InterPro; IPR052671; Acrosomal_SP-10-like.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   PANTHER; PTHR17571:SF34; ACROSOMAL PROTEIN SP-10; 1.
DR   PANTHER; PTHR17571; URINARY PROTEIN RUP /ACROSOMAL PROTEIN SP-10; 1.
DR   Pfam; PF00021; UPAR_LY6; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasmic vesicle; Direct protein sequencing;
KW   Glycoprotein; Proteomics identification; Reference proteome; Repeat;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..265
FT                   /note="Acrosomal protein SP-10"
FT                   /id="PRO_0000020760"
FT   REPEAT          66..70
FT                   /note="1-1"
FT   REPEAT          71..75
FT                   /note="1-2"
FT   REPEAT          85..88
FT                   /note="2-1"
FT   REPEAT          91..95
FT                   /note="1-3"
FT   REPEAT          110..114
FT                   /note="3-1"
FT   REPEAT          115..119
FT                   /note="3-2"
FT   REPEAT          120..123
FT                   /note="2-2"
FT   REPEAT          125..129
FT                   /note="3-3"
FT   REPEAT          135..139
FT                   /note="3-4"
FT   REPEAT          140..144
FT                   /note="3-5"
FT   REPEAT          145..148
FT                   /note="2-3"
FT   REPEAT          150..154
FT                   /note="3-6"
FT   REPEAT          155..159
FT                   /note="3-7"
FT   REPEAT          160..164
FT                   /note="3-8"
FT   REPEAT          165..168
FT                   /note="2-4"
FT   REPEAT          170..174
FT                   /note="3-9"
FT   REGION          62..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          66..95
FT                   /note="3 X 5 AA repeats of S-E-H-[GA]-S"
FT   REGION          85..168
FT                   /note="4 X 4 AA repeats of S-G-E-H"
FT   REGION          110..174
FT                   /note="9 X 5 AA repeats of [SV]-G-E-Q-[PSA]"
FT   COMPBIAS        69..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        258
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         41..224
FT                   /note="Missing (in isoform 11)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_004124"
FT   VAR_SEQ         41..184
FT                   /note="Missing (in isoform 10)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_004123"
FT   VAR_SEQ         41..135
FT                   /note="Missing (in isoform 6)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_004122"
FT   VAR_SEQ         41..110
FT                   /note="Missing (in isoform 4, isoform 5, isoform 8 and
FT                   isoform 9)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_004121"
FT   VAR_SEQ         41..95
FT                   /note="Missing (in isoform 3 and isoform 7)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_004120"
FT   VAR_SEQ         111..155
FT                   /note="Missing (in isoform 7)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_004125"
FT   VAR_SEQ         121..165
FT                   /note="Missing (in isoform 9)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_004126"
FT   VAR_SEQ         166..184
FT                   /note="Missing (in isoform 2 and isoform 5)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_004127"
FT   VAR_SEQ         185..224
FT                   /note="Missing (in isoform 8)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_004128"
FT   VARIANT         126
FT                   /note="G -> R (in dbSNP:rs34788353)"
FT                   /evidence="ECO:0000269|PubMed:8373955, ECO:0000269|Ref.4"
FT                   /id="VAR_050680"
FT   CONFLICT        91
FT                   /note="S -> E (in Ref. 7; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   265 AA;  28156 MW;  318216453F20D68A CRC64;
     MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEFFSLENPS DAEALYETSS
     GLNTLSEHGS SEHGSSKHTV AEHTSGEHAE SEHASGEPAA TEHAEGEHTV GEQPSGEQPS
     GEHLSGEQPL SELESGEQPS DEQPSGEHGS GEQPSGEQAS GEQPSGEHAS GEQASGAPIS
     STSTGTILNC YTCAYMNDQG KCLRGEGTCI TQNSQQCMLK KIFEGGKLQF MVQGCENMCP
     SMNLFSHGTR MQIICCRNQS FCNKI
//