ID   CDH_SALTY               Reviewed;         251 AA.
AC   P26219;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   04-NOV-2026, entry version 140.
DE   RecName: Full=CDP-diacylglycerol pyrophosphatase;
DE            EC=3.6.1.26;
DE   AltName: Full=CDP-diacylglycerol phosphatidylhydrolase;
DE   AltName: Full=CDP-diglyceride hydrolase;
GN   Name=cdh; Synonyms=ushB; OrderedLocusNames=STM4064;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=2548058; DOI=10.1111/j.1365-2958.1989.tb01806.x;
RA   Garrett A.R., Johnson L.A., Beacham I.R.;
RT   "Isolation, molecular characterization and expression of the ushB gene of
RT   Salmonella typhimurium which encodes a membrane-bound UDP-sugar
RT   hydrolase.";
RL   Mol. Microbiol. 3:177-186(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-
CC         3-phosphate + CMP + 2 H(+); Xref=Rhea:RHEA:15221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58332, ChEBI:CHEBI:58608,
CC         ChEBI:CHEBI:60377; EC=3.6.1.26;
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC       phosphatidate from CDP-diacylglycerol: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the Cdh family. {ECO:0000305}.
CC   -!- CAUTION: Was originally thought to be a UDP-sugar hydrolase.
CC       {ECO:0000305|PubMed:2548058}.
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DR   EMBL; X13380; CAA31757.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22904.1; -; Genomic_DNA.
DR   PIR; S04172; S04172.
DR   RefSeq; NP_462945.1; NC_003197.2.
DR   RefSeq; WP_000750761.1; NC_003197.2.
DR   AlphaFoldDB; P26219; -.
DR   SMR; P26219; -.
DR   STRING; 99287.STM4064; -.
DR   PaxDb; 99287-STM4064; -.
DR   GeneID; 1255591; -.
DR   KEGG; stm:STM4064; -.
DR   PATRIC; fig|99287.12.peg.4284; -.
DR   HOGENOM; CLU_077117_0_1_6; -.
DR   OMA; AAFWYFW; -.
DR   PhylomeDB; P26219; -.
DR   BioCyc; SENT99287:STM4064-MONOMER; -.
DR   UniPathway; UPA00609; UER00664.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046342; P:CDP-diacylglycerol catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.428.30; HIT family - CDH-like; 1.
DR   HAMAP; MF_00319; Cdh; 1.
DR   InterPro; IPR003763; CDP-diacylglyc_Pase.
DR   InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR   InterPro; IPR036265; HIT-like_sf.
DR   NCBIfam; TIGR00672; cdh; 1.
DR   NCBIfam; NF003986; PRK05471.1-5; 1.
DR   NCBIfam; NF003987; PRK05471.1-6; 1.
DR   Pfam; PF02611; CDH; 1.
DR   PIRSF; PIRSF001273; CDH; 1.
DR   SUPFAM; SSF54197; HIT-like; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Hydrolase; Lipid biosynthesis;
KW   Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW   Phospholipid metabolism; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..251
FT                   /note="CDP-diacylglycerol pyrophosphatase"
FT                   /id="PRO_0000198583"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        13
FT                   /note="V -> L (in Ref. 1; CAA31757)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   251 AA;  28368 MW;  2F4BBAB49BD870BE CRC64;
     MKKTGYFLLA VIVIVAAAGV GYWKFSGNPD ALREIVLEQC LPDQLQHQNP APCAEVKPRA
     GYVVFKDRHG PLQYLLMPTY RINGTESPLL LEPATPNFFW LAWQARGYMS KKYGHDIPDS
     AVSLAINSRL GRSQDHLHIH ISCIRPDVRE QLDNDLTRIS TRWLPLPGGL MGHEYLARRV
     TESELAQRSP FMMLAEEVPE ARDHMGRYAL AVVRQSDDSF VLLATERNLL TFNRASAEEI
     QDHSCAILSS R
//