ID YCY9_YEAST Reviewed; 155 AA. AC P25657; D6VRA0; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1992, sequence version 1. DT 02-SEP-2026, entry version 138. DE RecName: Full=Uncharacterized protein YCR099C; GN OrderedLocusNames=YCR099C; ORFNames=YCR99C; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=1574125; DOI=10.1038/357038a0; RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C., RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., RA Richterich P., Roberts A.B., Rodriguez F., Sanz E., RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., RA Sgouros J.G.; RT "The complete DNA sequence of yeast chromosome III."; RL Nature 357:38-46(1992). RN [2] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RX PubMed=24374639; DOI=10.1534/g3.113.008995; RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.; RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now."; RL G3 (Bethesda) 4:389-398(2014). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=17322287; DOI=10.1101/gr.6037607; RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J., RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., RA LaBaer J.; RT "Approaching a complete repository of sequence-verified protein-encoding RT clones for Saccharomyces cerevisiae."; RL Genome Res. 17:536-543(2007). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X59720; CAA42241.1; -; Genomic_DNA. DR EMBL; AY692670; AAT92689.1; -; Genomic_DNA. DR EMBL; BK006937; DAA07569.1; -; Genomic_DNA. DR PIR; S19515; S19515. DR RefSeq; NP_010023.1; NM_001178806.1. DR AlphaFoldDB; P25657; -. DR SMR; P25657; -. DR BioGRID; 31072; 34. DR DIP; DIP-2043N; -. DR FunCoup; P25657; 42. DR IntAct; P25657; 7. DR MINT; P25657; -. DR STRING; 4932.YCR099C; -. DR iPTMnet; P25657; -. DR PaxDb; 4932-YCR099C; -. DR EnsemblFungi; YCR099C_mRNA; YCR099C; YCR099C. DR GeneID; 850463; -. DR KEGG; sce:YCR099C; -. DR AGR; SGD:S000000696; -. DR SGD; S000000696; YCR099C. DR VEuPathDB; FungiDB:YCR099C; -. DR eggNOG; KOG3511; Eukaryota. DR HOGENOM; CLU_143022_0_0_1; -. DR InParanoid; P25657; -. DR OrthoDB; 4038455at2759; -. DR BioCyc; YEAST:G3O-29393-MONOMER; -. DR BioGRID-ORCS; 850463; 0 hits in 10 CRISPR screens. DR PRO; PR:P25657; -. DR Proteomes; UP000002311; Chromosome III. DR RNAct; P25657; protein. DR FunFam; 3.30.60.270:FF:000008; Vacuolar protein sorting/targeting protein PEP1; 1. DR Gene3D; 2.10.70.80; -; 1. DR Gene3D; 3.30.60.270; -; 1. DR InterPro; IPR031777; Sortilin_C. DR InterPro; IPR050310; VPS10-sortilin. DR PANTHER; PTHR12106; SORTILIN RELATED; 1. DR PANTHER; PTHR12106:SF27; SORTILIN-RELATED RECEPTOR; 1. DR Pfam; PF15901; Sortilin_C; 1. DR PROSITE; PS52072; VPS10P; 1. PE 4: Predicted; KW Disulfide bond; Protein transport; Receptor; Reference proteome; Transport. FT CHAIN 1..155 FT /note="Uncharacterized protein YCR099C" FT /id="PRO_0000202582" FT DOMAIN 1..133 FT /note="Vps10p" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01417" FT REGION 1..13 FT /note="10-bladed beta-propeller" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01417" FT REGION 14..62 FT /note="10CCa cysteine-knot" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01417" FT REGION 65..133 FT /note="10CCb cysteine-knot" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01417" FT DISULFID 14..46 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01417" FT DISULFID 29..62 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01417" FT DISULFID 65..118 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01417" FT DISULFID 72..84 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01417" FT DISULFID 97..131 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01417" SQ SEQUENCE 155 AA; 17960 MW; 61C7D8F2F00893D7 CRC64; MRSIFLLHFD YKTCEEEDFE DWNLADGKCL NGAKYMYKRR KQDARCLVKR TFKDMILHEI PCDSCTESDY ECSSEFVRDA KGDCIPDYDQ IALSDICDKA NGETVSLEPL QLIKGDKCKK PMEIEAMNIP CEKILRESSN GKKIATIENK FDFEI //