ID   YCA2_YEAST              Reviewed;         263 AA.
AC   P25565; D6VR08; Q8NIM4;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 4.
DT   18-JUN-2025, entry version 134.
DE   RecName: Full=Putative uncharacterized protein YCL002C;
GN   OrderedLocusNames=YCL002C; ORFNames=YCL2C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=1574125; DOI=10.1038/357038a0;
RA   Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA   Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA   Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA   Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA   Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA   Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA   Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA   Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA   Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA   Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA   Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA   Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA   Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA   Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA   Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA   Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA   Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA   Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA   Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA   Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA   Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA   Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA   Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA   Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA   Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA   Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA   Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA   Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA   Sgouros J.G.;
RT   "The complete DNA sequence of yeast chromosome III.";
RL   Nature 357:38-46(1992).
RN   [2]
RP   SEQUENCE REVISION.
RA   Valles G., Volckaerts G.;
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 240.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   REVISION OF GENE MODEL.
RX   PubMed=12775844; DOI=10.1126/science.1084337;
RA   Cliften P.F., Sudarsanam P., Desikan A., Fulton L., Fulton B., Majors J.,
RA   Waterston R., Cohen B.A., Johnston M.;
RT   "Finding functional features in Saccharomyces genomes by phylogenetic
RT   footprinting.";
RL   Science 301:71-76(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC42967.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAC42967.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X59720; CAC42967.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BK006937; DAA07477.2; -; Genomic_DNA.
DR   PIR; S19357; S19357.
DR   RefSeq; NP_009924.4; NM_001178652.2.
DR   AlphaFoldDB; P25565; -.
DR   SMR; P25565; -.
DR   BioGRID; 30976; 94.
DR   FunCoup; P25565; 28.
DR   IntAct; P25565; 1.
DR   STRING; 4932.YCL002C; -.
DR   PaxDb; 4932-YCL002C; -.
DR   PeptideAtlas; P25565; -.
DR   EnsemblFungi; YCL002C_mRNA; YCL002C; YCL002C.
DR   GeneID; 850353; -.
DR   KEGG; sce:YCL002C; -.
DR   AGR; SGD:S000000508; -.
DR   SGD; S000000508; YCL002C.
DR   VEuPathDB; FungiDB:YCL002C; -.
DR   eggNOG; ENOG502RXGR; Eukaryota.
DR   HOGENOM; CLU_095775_0_0_1; -.
DR   InParanoid; P25565; -.
DR   OMA; YQAQFLY; -.
DR   OrthoDB; 75720at2759; -.
DR   BioCyc; YEAST:G3O-29276-MONOMER; -.
DR   BioGRID-ORCS; 850353; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P25565; -.
DR   Proteomes; UP000002311; Chromosome III.
DR   RNAct; P25565; protein.
DR   GO; GO:0005829; C:cytosol; HDA:SGD.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; HDA:SGD.
PE   4: Predicted;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..263
FT                   /note="Putative uncharacterized protein YCL002C"
FT                   /id="PRO_0000202537"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   263 AA;  30197 MW;  E8ED84B6D9EA7BF0 CRC64;
     MLVIVLQGLA GFLSIIAILC QKRYNKLHRS IYGLSYDLFL LDFVGNGLYL YCALHYCYSS
     LVREQLSQRF PLFYPLNDAR SIPISSFLIL KDFCVSCCCM MVLRQLYYYR STKHIYQGIS
     ITSIIIISVF LVLGIFTYGC SISNLPLKNS GKFGVFYLEH INYLWVMANL LKCFKYVPQM
     SINWMGCSTV GLSSKFALIS FLAESIDLLG RLVIPTNALF YEIPFNSTPF WVKLIQFVTL
     LVILCQVQYV YVGRKPRLPK GKL
//