ID   BDNF_RAT                Reviewed;         249 AA.
AC   P23363; Q53YL8;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   04-NOV-2026, entry version 180.
DE   RecName: Full=Neurotrophic factor BDNF precursor form {ECO:0000305};
DE            Short=proBDNF;
DE   AltName: Full=Brain-derived neurotrophic factor;
DE   Contains:
DE     RecName: Full=Neurotrophic factor BDNF;
DE   Flags: Precursor;
GN   Name=Bdnf;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=1889806; DOI=10.1016/0888-7543(91)90436-i;
RA   Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L.,
RA   de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.;
RT   "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene
RT   structures, distributions, and chromosomal localizations.";
RL   Genomics 10:558-568(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1446835; DOI=10.1016/0378-1119(92)90148-i;
RA   Ohara O., Gahara Y., Teraoka H., Kitamura T.;
RT   "A rat brain-derived neurotrophic factor-encoding gene generates multiple
RT   transcripts through alternative use of 5' exons and polyadenylation
RT   sites.";
RL   Gene 121:383-386(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1966766; DOI=10.1101/sqb.1990.055.01.038;
RA   Yancopoulos G.D., Maisonpierre P.C., Ip N.Y., Aldrich T.H., Belluscio L.,
RA   Boulton T.G., Cobb M.H., Squinto S.P., Furth M.E.;
RT   "Neurotrophic factors, their receptors, and the signal transduction
RT   pathways they activate.";
RL   Cold Spring Harb. Symp. Quant. Biol. 55:371-379(1990).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=16376315; DOI=10.1016/j.brainres.2005.10.004;
RA   Liu Q.-R., Lu L., Zhu X.-G., Gong J.-P., Shaham Y., Uhl G.R.;
RT   "Rodent BDNF genes, novel promoters, novel splice variants, and regulation
RT   by cocaine.";
RL   Brain Res. 1067:1-12(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=17149751; DOI=10.1002/jnr.21139;
RA   Aid T., Kazantseva A., Piirsoo M., Palm K., Timmusk T.;
RT   "Mouse and rat BDNF gene structure and expression revisited.";
RL   J. Neurosci. Res. 85:525-535(2007).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Brain;
RA   Zhao L.X., Zhang J., Wang D.M., Yu X.J., Yue W., Pei X.T., Xu X.H.;
RT   "Reconstituting BDNF gene to bone marrow mesenchymal stem cells: serving as
RT   portals in the therapy of Parkinson's disease.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 8-249.
RX   PubMed=8461137; DOI=10.1016/0896-6273(93)90335-o;
RA   Timmusk T., Palm K., Metsis M., Reintam T., Palme V., Saarma M.,
RA   Persson H.;
RT   "Multiple promoters direct tissue-specific expression of the rat BDNF
RT   gene.";
RL   Neuron 10:475-489(1993).
RN   [9]
RP   NUCLEOTIDE SEQUENCE OF 187-229.
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
RA   Hallboeoek F., Ibanez C.F., Persson H.;
RT   "Evolutionary studies of the nerve growth factor family reveal a novel
RT   member abundantly expressed in Xenopus ovary.";
RL   Neuron 6:845-858(1991).
CC   -!- FUNCTION: Important signaling molecule that activates signaling
CC       cascades downstream of NTRK2 (By similarity). During development,
CC       promotes the survival and differentiation of selected neuronal
CC       populations of the peripheral and central nervous systems. Participates
CC       in axonal growth, pathfinding and in the modulation of dendritic growth
CC       and morphology. Major regulator of synaptic transmission and plasticity
CC       at adult synapses in many regions of the CNS. The versatility of BDNF
CC       is emphasized by its contribution to a range of adaptive neuronal
CC       responses including long-term potentiation (LTP), long-term depression
CC       (LTD), certain forms of short-term synaptic plasticity, as well as
CC       homeostatic regulation of intrinsic neuronal excitability (By
CC       similarity). {ECO:0000250|UniProtKB:P21237,
CC       ECO:0000250|UniProtKB:P23560}.
CC   -!- FUNCTION: [Neurotrophic factor BDNF precursor form]: Important
CC       signaling molecule that activates signaling cascades downstream of
CC       NTRK2. Activates signaling cascades via the heterodimeric receptor
CC       formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role
CC       in synaptic plasticity and long-term depression (LTD). Binding to NGFR
CC       and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone
CC       collapse. {ECO:0000250|UniProtKB:P21237}.
CC   -!- SUBUNIT: Monomers and homodimers (By similarity). Binds to NTRK2/TRKB.
CC       Can form heterodimers with other neurotrophin family members, such as
CC       NTF3 and NTF4 (in vitro), but the physiological relevance of this is
CC       not clear (By similarity). BDNF precursor form: interacts with the
CC       heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower
CC       affinity for the heterodimer formed by NGFR and SORCS2 (By similarity).
CC       {ECO:0000250|UniProtKB:P21237, ECO:0000250|UniProtKB:P23560}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P23560}.
CC   -!- SUBCELLULAR LOCATION: [Neurotrophic factor BDNF precursor form]:
CC       Secreted {ECO:0000250|UniProtKB:P23560}. Note=A proportion of BDNF is
CC       secreted as immature precursor (proBDNF).
CC       {ECO:0000250|UniProtKB:P23560}.
CC   -!- PTM: [Neurotrophic factor BDNF precursor form]: N-glycosylated and
CC       glycosulfated, contrary to mature BDNF. {ECO:0000250|UniProtKB:P23560}.
CC   -!- PTM: Mature BDNF is produced by proteolytic removal of the propeptide,
CC       catalyzed by a FURIN family member. In addition, the precursor form is
CC       proteolytically cleaved within the propeptide, but this is not an
CC       obligatory intermediate for the production of mature BDNF. Can be
CC       converted into mature BDNF by plasmin (PLG).
CC       {ECO:0000250|UniProtKB:P23560}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; M61175; AAA16841.1; -; mRNA.
DR   EMBL; M61178; AAA63483.1; -; Genomic_DNA.
DR   EMBL; D10938; BAA01732.1; -; Genomic_DNA.
DR   EMBL; AY559248; AAS67380.1; -; mRNA.
DR   EMBL; AY559249; AAS67381.1; -; mRNA.
DR   EMBL; AY559250; AAS67382.1; -; mRNA.
DR   EMBL; EF125675; ABM30161.1; -; mRNA.
DR   EMBL; EF125676; ABM30162.1; -; mRNA.
DR   EMBL; EF125677; ABM30163.1; -; mRNA.
DR   EMBL; EF125678; ABM30164.1; -; mRNA.
DR   EMBL; EF125679; ABM30165.1; -; mRNA.
DR   EMBL; EF125680; ABM30166.1; -; mRNA.
DR   EMBL; EF125686; ABM30172.1; -; mRNA.
DR   EMBL; EF125687; ABM30173.1; -; mRNA.
DR   EMBL; EF125688; ABM30174.1; -; mRNA.
DR   EMBL; EF125689; ABM30175.1; -; mRNA.
DR   EMBL; EF125690; ABM30176.1; -; mRNA.
DR   EMBL; AY176065; AAO17828.1; -; mRNA.
DR   EMBL; BC087634; AAH87634.1; -; mRNA.
DR   EMBL; X67108; CAA47481.1; -; mRNA.
DR   PIR; B60536; B40304.
DR   RefSeq; NP_001257559.1; NM_001270630.1.
DR   RefSeq; NP_001257560.1; NM_001270631.1.
DR   RefSeq; NP_001257561.1; NM_001270632.1.
DR   RefSeq; NP_001257562.1; NM_001270633.1.
DR   RefSeq; NP_001257563.1; NM_001270634.1.
DR   RefSeq; NP_001257564.1; NM_001270635.1.
DR   RefSeq; NP_001257565.1; NM_001270636.1.
DR   RefSeq; NP_001257566.1; NM_001270637.1.
DR   RefSeq; NP_001257567.1; NM_001270638.1.
DR   RefSeq; NP_036645.2; NM_012513.4.
DR   AlphaFoldDB; P23363; -.
DR   SMR; P23363; -.
DR   BioGRID; 246413; 3.
DR   FunCoup; P23363; 1666.
DR   IntAct; P23363; 3.
DR   STRING; 10116.ENSRNOP00000064356; -.
DR   GlyCosmos; P23363; 1 site, No reported glycans.
DR   GlyGen; P23363; 1 site.
DR   PhosphoSitePlus; P23363; -.
DR   PaxDb; 10116-ENSRNOP00000064356; -.
DR   ABCD; P23363; 2 sequenced antibodies.
DR   Ensembl; ENSRNOT00000077703.3; ENSRNOP00000072849.1; ENSRNOG00000047466.4.
DR   Ensembl; ENSRNOT00000078543.3; ENSRNOP00000072315.1; ENSRNOG00000047466.4.
DR   Ensembl; ENSRNOT00000080190.3; ENSRNOP00000073265.1; ENSRNOG00000047466.4.
DR   Ensembl; ENSRNOT00000083289.3; ENSRNOP00000074338.1; ENSRNOG00000047466.4.
DR   Ensembl; ENSRNOT00000089233.3; ENSRNOP00000075479.1; ENSRNOG00000047466.4.
DR   Ensembl; ENSRNOT00000090445.3; ENSRNOP00000073685.1; ENSRNOG00000047466.4.
DR   Ensembl; ENSRNOT00055040184; ENSRNOP00055032626; ENSRNOG00055023387.
DR   Ensembl; ENSRNOT00055040219; ENSRNOP00055032659; ENSRNOG00055023387.
DR   Ensembl; ENSRNOT00055040247; ENSRNOP00055032687; ENSRNOG00055023387.
DR   Ensembl; ENSRNOT00055040253; ENSRNOP00055032692; ENSRNOG00055023387.
DR   Ensembl; ENSRNOT00055040264; ENSRNOP00055032703; ENSRNOG00055023387.
DR   Ensembl; ENSRNOT00055040276; ENSRNOP00055032715; ENSRNOG00055023387.
DR   Ensembl; ENSRNOT00060002562; ENSRNOP00060001682; ENSRNOG00060001681.
DR   Ensembl; ENSRNOT00060002573; ENSRNOP00060001691; ENSRNOG00060001681.
DR   Ensembl; ENSRNOT00060002593; ENSRNOP00060001703; ENSRNOG00060001681.
DR   Ensembl; ENSRNOT00060002598; ENSRNOP00060001706; ENSRNOG00060001681.
DR   Ensembl; ENSRNOT00060002602; ENSRNOP00060001708; ENSRNOG00060001681.
DR   Ensembl; ENSRNOT00060002608; ENSRNOP00060001714; ENSRNOG00060001681.
DR   Ensembl; ENSRNOT00065026701; ENSRNOP00065020948; ENSRNOG00065016064.
DR   Ensembl; ENSRNOT00065026727; ENSRNOP00065020974; ENSRNOG00065016064.
DR   Ensembl; ENSRNOT00065026750; ENSRNOP00065020997; ENSRNOG00065016064.
DR   Ensembl; ENSRNOT00065026754; ENSRNOP00065021001; ENSRNOG00065016064.
DR   Ensembl; ENSRNOT00065026758; ENSRNOP00065021005; ENSRNOG00065016064.
DR   Ensembl; ENSRNOT00065026769; ENSRNOP00065021016; ENSRNOG00065016064.
DR   GeneID; 24225; -.
DR   KEGG; rno:24225; -.
DR   AGR; RGD:2202; -.
DR   CTD; 627; -.
DR   RGD; 2202; Bdnf.
DR   eggNOG; ENOG502QRU8; Eukaryota.
DR   GeneTree; ENSGT00390000007725; -.
DR   InParanoid; P23363; -.
DR   OrthoDB; 8959386at2759; -.
DR   PhylomeDB; P23363; -.
DR   Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
DR   Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR   Reactome; R-RNO-9026527; Activated NTRK2 signals through PLCG1.
DR   Reactome; R-RNO-9028731; Activated NTRK2 signals through FRS2 and FRS3.
DR   Reactome; R-RNO-9032759; NTRK2 activates RAC1.
DR   PRO; PR:P23363; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000047466; Expressed in heart and 7 other cell types or tissues.
DR   ExpressionAtlas; P23363; baseline and differential.
DR   GO; GO:0030424; C:axon; IDA:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISO:RGD.
DR   GO; GO:0030425; C:dendrite; IDA:RGD.
DR   GO; GO:0005576; C:extracellular region; IDA:RGD.
DR   GO; GO:0098978; C:glutamatergic synapse; ISO:RGD.
DR   GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; ISO:RGD.
DR   GO; GO:0030061; C:mitochondrial crista; IDA:RGD.
DR   GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR   GO; GO:0098992; C:neuronal dense core vesicle; ISO:RGD.
DR   GO; GO:0043204; C:perikaryon; IDA:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0098794; C:postsynapse; IEA:GOC.
DR   GO; GO:0098793; C:presynapse; ISO:RGD.
DR   GO; GO:0030141; C:secretory granule; IDA:RGD.
DR   GO; GO:0099503; C:secretory vesicle; ISO:RGD.
DR   GO; GO:0008021; C:synaptic vesicle; IDA:RGD.
DR   GO; GO:0043195; C:terminal bouton; IDA:RGD.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005169; F:neurotrophin TRKB receptor binding; IDA:RGD.
DR   GO; GO:0048675; P:axon extension; ISO:RGD.
DR   GO; GO:0007411; P:axon guidance; ISO:RGD.
DR   GO; GO:0007412; P:axon target recognition; ISO:RGD.
DR   GO; GO:0001662; P:behavioral fear response; ISO:RGD.
DR   GO; GO:0048148; P:behavioral response to cocaine; IMP:RGD.
DR   GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IEP:RGD.
DR   GO; GO:0071874; P:cellular response to norepinephrine stimulus; IEP:RGD.
DR   GO; GO:0035865; P:cellular response to potassium ion; IEP:RGD.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
DR   GO; GO:0002544; P:chronic inflammatory response; IEP:RGD.
DR   GO; GO:0007623; P:circadian rhythm; ISO:RGD.
DR   GO; GO:0050890; P:cognition; IEP:RGD.
DR   GO; GO:0048668; P:collateral sprouting; ISO:RGD.
DR   GO; GO:1990708; P:conditioned place preference; IMP:RGD.
DR   GO; GO:0016358; P:dendrite development; ISO:RGD.
DR   GO; GO:0097484; P:dendrite extension; ISO:RGD.
DR   GO; GO:0060079; P:excitatory postsynaptic potential; IMP:RGD.
DR   GO; GO:0042596; P:fear response; ISO:RGD.
DR   GO; GO:0007631; P:feeding behavior; ISO:RGD.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; ISO:RGD.
DR   GO; GO:0014047; P:glutamate secretion; ISO:RGD.
DR   GO; GO:0060080; P:inhibitory postsynaptic potential; ISO:RGD.
DR   GO; GO:0048839; P:inner ear development; ISO:RGD.
DR   GO; GO:0007612; P:learning; IMP:RGD.
DR   GO; GO:0007611; P:learning or memory; ISO:RGD.
DR   GO; GO:0042490; P:mechanoreceptor differentiation; ISO:RGD.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IMP:RGD.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR   GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; ISO:RGD.
DR   GO; GO:0010832; P:negative regulation of myotube differentiation; IMP:BHF-UCL.
DR   GO; GO:0007406; P:negative regulation of neuroblast proliferation; ISO:RGD.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:RGD.
DR   GO; GO:0043069; P:negative regulation of programmed cell death; ISO:RGD.
DR   GO; GO:0045843; P:negative regulation of striated muscle tissue development; IMP:RGD.
DR   GO; GO:0032229; P:negative regulation of synaptic transmission, GABAergic; ISO:RGD.
DR   GO; GO:0021675; P:nerve development; ISO:RGD.
DR   GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IDA:RGD.
DR   GO; GO:0030182; P:neuron differentiation; TAS:RGD.
DR   GO; GO:1990138; P:neuron projection extension; IDA:RGD.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR   GO; GO:0031102; P:neuron projection regeneration; IMP:RGD.
DR   GO; GO:0008038; P:neuron recognition; ISO:RGD.
DR   GO; GO:0048680; P:positive regulation of axon regeneration; IMP:RGD.
DR   GO; GO:0048672; P:positive regulation of collateral sprouting; ISO:RGD.
DR   GO; GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IMP:RGD.
DR   GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:RGD.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; ISO:RGD.
DR   GO; GO:2000324; P:positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway; IDA:MGI.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IGI:MGI.
DR   GO; GO:0051965; P:positive regulation of synapse assembly; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0031099; P:regeneration; IDA:RGD.
DR   GO; GO:0030516; P:regulation of axon extension; IMP:RGD.
DR   GO; GO:0048670; P:regulation of collateral sprouting; ISO:RGD.
DR   GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IDA:RGD.
DR   GO; GO:0043523; P:regulation of neuron apoptotic process; ISO:RGD.
DR   GO; GO:0046668; P:regulation of retinal cell programmed cell death; ISO:RGD.
DR   GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IDA:RGD.
DR   GO; GO:0048167; P:regulation of synaptic plasticity; ISO:RGD.
DR   GO; GO:0014823; P:response to activity; IEP:RGD.
DR   GO; GO:0072347; P:response to anesthetic; IEP:RGD.
DR   GO; GO:0010996; P:response to auditory stimulus; IEP:RGD.
DR   GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
DR   GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR   GO; GO:0032094; P:response to food; IEP:RGD.
DR   GO; GO:0009725; P:response to hormone; IEP:RGD.
DR   GO; GO:0055093; P:response to hyperoxia; IEP:RGD.
DR   GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR   GO; GO:1902065; P:response to L-glutamate; IEP:RGD.
DR   GO; GO:0009642; P:response to light intensity; IEP:RGD.
DR   GO; GO:0009416; P:response to light stimulus; IEP:RGD.
DR   GO; GO:0043278; P:response to morphine; IEP:RGD.
DR   GO; GO:1990089; P:response to nerve growth factor; IEP:RGD.
DR   GO; GO:0031667; P:response to nutrient levels; IEP:RGD.
DR   GO; GO:0035864; P:response to potassium ion; IEP:RGD.
DR   GO; GO:0034612; P:response to tumor necrosis factor; IEP:RGD.
DR   GO; GO:0033189; P:response to vitamin A; IEP:RGD.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR   GO; GO:0007416; P:synapse assembly; ISO:RGD.
DR   GO; GO:0061193; P:taste bud development; ISO:RGD.
DR   GO; GO:0099183; P:trans-synaptic signaling by BDNF, modulating synaptic transmission; ISO:RGD.
DR   GO; GO:0001657; P:ureteric bud development; ISO:RGD.
DR   FunFam; 2.10.90.10:FF:000002; Brain-derived neurotrophic factor; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589:SF3; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..249
FT                   /note="Neurotrophic factor BDNF precursor form"
FT                   /id="PRO_0000447540"
FT   PROPEP          19..130
FT                   /evidence="ECO:0000250|UniProtKB:P21237"
FT                   /id="PRO_0000019643"
FT   CHAIN           131..249
FT                   /note="Neurotrophic factor BDNF"
FT                   /id="PRO_0000019644"
FT   SITE            59..60
FT                   /note="Cleavage; by MBTPS1"
FT                   /evidence="ECO:0000250|UniProtKB:P23560"
FT   CARBOHYD        123
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        143..210
FT                   /evidence="ECO:0000250|UniProtKB:P23560"
FT   DISULFID        188..239
FT                   /evidence="ECO:0000250|UniProtKB:P23560"
FT   DISULFID        198..241
FT                   /evidence="ECO:0000250|UniProtKB:P23560"
SQ   SEQUENCE   249 AA;  28109 MW;  F9CAAA5DEF9A78B7 CRC64;
     MTILFLTMVI SYFGCMKAAP MKEANVHGQG NLAYPAVRTH GTLESVNGPR AGSRGLTTTS
     LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD
     AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK
     QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV
     CTLTIKRGR
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