ID   HSP6C_DROME             Reviewed;         199 AA.
AC   P22979; Q4V3R7; Q9VSW9;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   04-NOV-2026, entry version 173.
DE   RecName: Full=Heat shock protein 67B3;
DE   AltName: Full=Heat shock 18 kDa protein;
GN   Name=Hsp67Bc; ORFNames=CG4190;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3123699; DOI=10.1016/0022-2836(87)90309-3;
RA   Pauli D., Tonka C.H.;
RT   "A Drosophila heat shock gene from locus 67B is expressed during
RT   embryogenesis and pupation.";
RL   J. Mol. Biol. 198:235-240(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA   Park S., Wan K., Yu C., Celniker S.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- INTERACTION:
CC       P22979; Q94524: Dlc90F; NbExp=6; IntAct=EBI-165408, EBI-158251;
CC   -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis and pupation.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA29788.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X06542; CAA29788.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE014296; AAF50292.1; -; Genomic_DNA.
DR   EMBL; BT023289; AAY55705.1; -; mRNA.
DR   PIR; S00900; S00900.
DR   RefSeq; NP_523994.1; NM_079270.3.
DR   AlphaFoldDB; P22979; -.
DR   SMR; P22979; -.
DR   BioGRID; 64468; 23.
DR   FunCoup; P22979; 2.
DR   IntAct; P22979; 19.
DR   STRING; 7227.FBpp0076225; -.
DR   PaxDb; 7227-FBpp0076225; -.
DR   PeptideAtlas; P22979; -.
DR   DNASU; 39071; -.
DR   EnsemblMetazoa; FBtr0076497; FBpp0076225; FBgn0001229.
DR   GeneID; 39071; -.
DR   KEGG; dme:Dmel_CG4190; -.
DR   AGR; FB:FBgn0001229; -.
DR   CTD; 39071; -.
DR   FlyBase; FBgn0001229; Hsp67Bc.
DR   VEuPathDB; VectorBase:FBgn0001229; -.
DR   eggNOG; KOG3591; Eukaryota.
DR   HOGENOM; CLU_095001_1_1_1; -.
DR   InParanoid; P22979; -.
DR   OMA; AIVCKLS; -.
DR   OrthoDB; 1431247at2759; -.
DR   PhylomeDB; P22979; -.
DR   Reactome; R-DME-3371571; HSF1-dependent transactivation.
DR   BioGRID-ORCS; 39071; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 39071; -.
DR   PRO; PR:P22979; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0001229; Expressed in T neuron T5a (Drosophila) in embryonic/larval optic lobe (Drosophila) and 100 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0140309; F:unfolded protein holdase activity; IMP:FlyBase.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IMP:FlyBase.
DR   GO; GO:0016239; P:positive regulation of macroautophagy; IMP:FlyBase.
DR   GO; GO:0042026; P:protein refolding; ISM:FlyBase.
DR   GO; GO:0009408; P:response to heat; IDA:FlyBase.
DR   CDD; cd06526; metazoan_ACD; 1.
DR   FunFam; 2.60.40.790:FF:000110; heat shock protein 67B3; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   PANTHER; PTHR45640:SF13; HEAT SHOCK PROTEIN 22-RELATED; 1.
DR   PANTHER; PTHR45640; HEAT SHOCK PROTEIN HSP-12.2-RELATED; 1.
DR   Pfam; PF00011; HSP20; 1.
DR   PRINTS; PR00299; ACRYSTALLIN.
DR   SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Stress response.
FT   CHAIN           1..199
FT                   /note="Heat shock protein 67B3"
FT                   /id="PRO_0000125968"
FT   DOMAIN          63..170
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   REGION          173..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..199
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        127
FT                   /note="R -> P (in Ref. 1; CAA29788)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   199 AA;  22180 MW;  E0A5622177D69C22 CRC64;
     MPDIPFVLNL DSPDSMYYGH DMFPNRMYRR LHSRQHHDLD LHTLGLIARM GAHAHHLVAN
     KRNGELAALS RGGASNKQGN FEVHLDVGLF QPGELTVKLV NECIVVEGKH EEREDDHGHV
     SRHFVRRYPL PKEFDSDAIV STLSEDGVLN ITVPPLVSKE ELKERIIPIK HVGPSDLFQN
     GNGHKEAGPA ASASEPEAK
//