ID   EVI2A_HUMAN             Reviewed;         236 AA.
AC   P22794; B2R5X2; B4DHX8;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   10-JUN-2026, entry version 180.
DE   RecName: Full=Protein EVI2A;
DE   AltName: Full=Ecotropic viral integration site 2A protein homolog;
DE            Short=EVI-2A;
DE   Flags: Precursor;
GN   Name=EVI2A; Synonyms=EVDA, EVI2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2117566; DOI=10.1016/0888-7543(90)90199-5;
RA   Cawthon R.M., O'Connell P., Buchberg A.M., Viskochil D., Weiss R.B.,
RA   Culver M., Stevens J., Jenkins N.A., Copeland N.G., White R.;
RT   "Identification and characterization of transcripts from the
RT   neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and
RT   mapping of other transcripts.";
RL   Genomics 7:555-565(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Caudate nucleus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May complex with itself or/and other proteins within the
CC       membrane, to function as part of a cell-surface receptor.
CC   -!- INTERACTION:
CC       P22794; P27449: ATP6V0C; NbExp=3; IntAct=EBI-2870359, EBI-721179;
CC       P22794; Q9HD26: GOPC; NbExp=2; IntAct=EBI-2870359, EBI-349832;
CC       P22794; P21145: MAL; NbExp=3; IntAct=EBI-2870359, EBI-3932027;
CC       P22794; Q13021: MALL; NbExp=3; IntAct=EBI-2870359, EBI-750078;
CC       P22794; Q04941: PLP2; NbExp=3; IntAct=EBI-2870359, EBI-608347;
CC       P22794; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-2870359, EBI-10485931;
CC       P22794; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-2870359, EBI-10244780;
CC       P22794; Q9Y5Z9: UBIAD1; NbExp=3; IntAct=EBI-2870359, EBI-2819725;
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P22794-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P22794-2; Sequence=VSP_038859;
CC   -!- SIMILARITY: Belongs to the EVI2A family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA52413.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAG35269.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M55266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M55267; AAA52413.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AK295311; BAG58290.1; -; mRNA.
DR   EMBL; AK312348; BAG35269.1; ALT_INIT; mRNA.
DR   EMBL; BC035572; AAH35572.2; -; mRNA.
DR   CCDS; CCDS32608.1; -. [P22794-2]
DR   CCDS; CCDS42293.1; -. [P22794-1]
DR   PIR; A35329; A35329.
DR   RefSeq; NP_001003927.1; NM_001003927.3. [P22794-2]
DR   RefSeq; NP_055025.2; NM_014210.4. [P22794-1]
DR   AlphaFoldDB; P22794; -.
DR   SMR; P22794; -.
DR   BioGRID; 108424; 20.
DR   FunCoup; P22794; 10.
DR   IntAct; P22794; 19.
DR   NDEx; IQUERY-CP-EVI2A; 1 NDEx IQuery Curated Pathway.
DR   STRING; 9606.ENSP00000247270; -.
DR   GlyCosmos; P22794; 5 sites, No reported glycans.
DR   GlyGen; P22794; 5 sites.
DR   iPTMnet; P22794; -.
DR   PhosphoSitePlus; P22794; -.
DR   BioMuta; EVI2A; -.
DR   DMDM; 292495009; -.
DR   MassIVE; P22794; -.
DR   PaxDb; 9606-ENSP00000247270; -.
DR   PeptideAtlas; P22794; -.
DR   ProteomicsDB; 54039; -. [P22794-1]
DR   ProteomicsDB; 54040; -. [P22794-2]
DR   Antibodypedia; 27020; 80 antibodies from 20 providers.
DR   DNASU; 2123; -.
DR   Ensembl; ENST00000247270.3; ENSP00000247270.3; ENSG00000126860.13. [P22794-2]
DR   Ensembl; ENST00000461237.5; ENSP00000418064.1; ENSG00000126860.13. [P22794-1]
DR   Ensembl; ENST00000462804.3; ENSP00000420557.3; ENSG00000126860.13. [P22794-1]
DR   Ensembl; ENST00000895991.1; ENSP00000566050.1; ENSG00000126860.13. [P22794-1]
DR   GeneID; 2123; -.
DR   KEGG; hsa:2123; -.
DR   MANE-Select; ENST00000462804.3; ENSP00000420557.3; NM_014210.4; NP_055025.2.
DR   UCSC; uc002hgl.4; human. [P22794-1]
DR   AGR; HGNC:3499; -.
DR   ClinPGx; PA27913; -.
DR   CTD; 2123; -.
DR   DisGeNET; 2123; -.
DR   GeneCards; EVI2A; -.
DR   HGNC; HGNC:3499; EVI2A.
DR   HPA; ENSG00000126860; Group enriched (brain, lymphoid tissue).
DR   MalaCards; EVI2A; -.
DR   MIM; 158380; gene.
DR   OpenTargets; ENSG00000126860; -.
DR   VEuPathDB; HostDB:ENSG00000126860; -.
DR   eggNOG; ENOG502S3SG; Eukaryota.
DR   GeneTree; ENSGT00390000003004; -.
DR   HOGENOM; CLU_073339_0_0_1; -.
DR   InParanoid; P22794; -.
DR   OrthoDB; 9448427at2759; -.
DR   PAN-GO; P22794; 0 GO annotations based on evolutionary models.
DR   PhylomeDB; P22794; -.
DR   PathwayCommons; P22794; -.
DR   SignaLink; P22794; -.
DR   Agora; ENSG00000126860; -.
DR   BioGRID-ORCS; 2123; 15 hits in 1146 CRISPR screens.
DR   ChiTaRS; EVI2A; human.
DR   GenomeRNAi; 2123; -.
DR   Pharos; P22794; Tbio.
DR   PRO; PR:P22794; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P22794; protein.
DR   Bgee; ENSG00000126860; Expressed in corpus callosum and 179 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; NAS:UniProtKB.
DR   InterPro; IPR008608; Ectropic_vir_integratn_site_2A.
DR   PANTHER; PTHR15568; ECOTROPIC VIRAL INTEGRATION SITE 2A; 1.
DR   PANTHER; PTHR15568:SF0; PROTEIN EVI2A; 1.
DR   Pfam; PF05399; EVI2A; 1.
DR   PIRSF; PIRSF019625; EVI_S2A; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW   Proteomics identification; Proto-oncogene; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..236
FT                   /note="Protein EVI2A"
FT                   /id="PRO_0000021211"
FT   TOPO_DOM        31..133
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          217..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..236
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         211
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P20934"
FT   CARBOHYD        31
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        49
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        112
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1
FT                   /note="M -> MLLRSWFGNKDFQALPILARLPSM (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_038859"
SQ   SEQUENCE   236 AA;  26213 MW;  5C62B05746BD975D CRC64;
     MPTDMEHTGH YLHLAFLMTT VFSLSPGTKA NYTRLWANST SSWDSVIQNK TGRNQNENIN
     TNPITPEVDY KGNSTNMPET SHIVALTSKS EQELYIPSVV SNSPSTVQSI ENTSKSHGEI
     FKKDVCAENN NNMAMLICLI IIAVLFLICT FLFLSTVVLA NKVSSLRRSK QVGKRQPRSN
     GDFLASGLWP AESDTWKRTK QLTGPNLVMQ STGVLTATRE RKDEEGTEKL TNKQIG
//